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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 15

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Extracellular calcium modulates actions of orthosteric and allosteric ligands on metabotropic glutamate receptor 1α.
Jiang JY, Nagaraju M, Meyer RC, Zhang L, Hamelberg D, Hall RA, Brown EM, Conn PJ, Yang JJ
(2014) J Biol Chem 289: 1649-61
MeSH Terms: Allosteric Regulation, Amino Acid Substitution, Benzoates, Binding Sites, Calcium, Calcium Signaling, Carbamates, Excitatory Amino Acid Agonists, Glycine, HEK293 Cells, Humans, Mutation, Missense, Protein Structure, Tertiary, Quisqualic Acid, Receptors, Metabotropic Glutamate, Xanthenes
Added February 19, 2015
0 Communities
1 Members
0 Resources
16 MeSH Terms
Development of an assay for high-throughput energy expenditure monitoring in the zebrafish.
Renquist BJ, Zhang C, Williams SY, Cone RD
(2013) Zebrafish 10: 343-52
MeSH Terms: Animals, Energy Metabolism, Female, HEK293 Cells, Humans, Indicators and Reagents, Male, Oxazines, Xanthenes, Zebrafish
Added December 4, 2014
0 Communities
2 Members
0 Resources
10 MeSH Terms
Activation of group II metabotropic glutamate receptors induces long-term depression of excitatory synaptic transmission in the substantia nigra pars reticulata.
Johnson KA, Niswender CM, Conn PJ, Xiang Z
(2011) Neurosci Lett 504: 102-106
MeSH Terms: Amino Acids, Animals, Basal Ganglia, Bridged Bicyclo Compounds, Heterocyclic, Data Interpretation, Statistical, Dose-Response Relationship, Drug, Excitatory Amino Acid Antagonists, Excitatory Postsynaptic Potentials, Mice, Mice, Knockout, Neuronal Plasticity, Patch-Clamp Techniques, Rats, Rats, Sprague-Dawley, Receptors, Metabotropic Glutamate, Substantia Nigra, Synaptic Transmission, Xanthenes, gamma-Aminobutyric Acid
Added February 19, 2015
0 Communities
2 Members
0 Resources
19 MeSH Terms
XZH-5 inhibits STAT3 phosphorylation and causes apoptosis in human hepatocellular carcinoma cells.
Liu Y, Liu A, Xu Z, Yu W, Wang H, Li C, Lin J
(2011) Apoptosis 16: 502-10
MeSH Terms: Antineoplastic Agents, Apoptosis, Carcinoma, Hepatocellular, Cell Line, Tumor, Cell Proliferation, Cyclic S-Oxides, Histidine, Humans, Interleukin-6, Liver Neoplasms, Phenylurea Compounds, Phosphorylation, STAT3 Transcription Factor, Xanthenes
Added June 14, 2013
0 Communities
1 Members
0 Resources
14 MeSH Terms
Pet-1 is required across different stages of life to regulate serotonergic function.
Liu C, Maejima T, Wyler SC, Casadesus G, Herlitze S, Deneris ES
(2010) Nat Neurosci 13: 1190-8
MeSH Terms: 8-Hydroxy-2-(di-n-propylamino)tetralin, Age Factors, Analysis of Variance, Animals, Animals, Newborn, Cell Differentiation, Chromatin Immunoprecipitation, Estrogen Antagonists, Excitatory Amino Acid Antagonists, Extracellular Matrix Proteins, Gene Expression Regulation, Developmental, In Vitro Techniques, Luminescent Proteins, Male, Maze Learning, Mice, Mice, Inbred C57BL, Mice, Transgenic, Motor Activity, Neurons, Patch-Clamp Techniques, Protein-Lysine 6-Oxidase, RNA, Messenger, Raphe Nuclei, Receptor, Serotonin, 5-HT1A, Receptor, Serotonin, 5-HT1B, Serotonin, Serotonin Plasma Membrane Transport Proteins, Serotonin Receptor Agonists, Somatosensory Cortex, Tamoxifen, Transcription Factors, Tryptophan Hydroxylase, Xanthenes
Added April 22, 2013
0 Communities
0 Members
1 Resources
34 MeSH Terms
Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells.
Sheffler DJ, Conn PJ
(2008) Neuropharmacology 55: 419-27
MeSH Terms: Allosteric Regulation, Amino Acids, Animals, Binding, Competitive, Calcium, Cell Line, Transformed, Cricetinae, Cyclic AMP, Dose-Response Relationship, Drug, Excitatory Amino Acid Agonists, Excitatory Amino Acid Antagonists, Glutamic Acid, Mitogen-Activated Protein Kinase 3, Pyrans, Quinolines, Radioligand Assay, Receptors, Metabotropic Glutamate, Signal Transduction, Time Factors, Transfection, Tritium, Xanthenes
Added February 19, 2015
0 Communities
1 Members
0 Resources
22 MeSH Terms
Group III mGluR regulation of synaptic transmission at the SC-CA1 synapse is developmentally regulated.
Ayala JE, Niswender CM, Luo Q, Banko JL, Conn PJ
(2008) Neuropharmacology 54: 804-14
MeSH Terms: Age Factors, Amino Acids, Aminobutyrates, Animals, Animals, Newborn, Cell Line, Transformed, Dose-Response Relationship, Drug, Excitatory Amino Acid Agonists, Excitatory Amino Acid Antagonists, Hippocampus, Humans, In Vitro Techniques, Male, Neural Pathways, Neurons, Patch-Clamp Techniques, Rats, Rats, Sprague-Dawley, Receptors, AMPA, Synapses, Synaptic Transmission, Transfection, Xanthenes
Added February 19, 2015
0 Communities
2 Members
0 Resources
23 MeSH Terms
A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors.
Niswender CM, Johnson KA, Luo Q, Ayala JE, Kim C, Conn PJ, Weaver CD
(2008) Mol Pharmacol 73: 1213-24
MeSH Terms: Adrenergic Agonists, Allosteric Regulation, Amino Acids, Animals, Biological Assay, Carbachol, Cell Line, Dose-Response Relationship, Drug, G Protein-Coupled Inwardly-Rectifying Potassium Channels, GTP-Binding Protein alpha Subunits, Gi-Go, Humans, Ion Channel Gating, Ligands, Muscarinic Agonists, Pertussis Toxin, Rats, Receptors, Metabotropic Glutamate, Receptors, Muscarinic, Reproducibility of Results, Thallium, Xanthenes
Added February 16, 2015
0 Communities
3 Members
0 Resources
21 MeSH Terms
A genome-wide approach to identify genetic variants that contribute to etoposide-induced cytotoxicity.
Huang RS, Duan S, Bleibel WK, Kistner EO, Zhang W, Clark TA, Chen TX, Schweitzer AC, Blume JE, Cox NJ, Dolan ME
(2007) Proc Natl Acad Sci U S A 104: 9758-63
MeSH Terms: Antineoplastic Agents, Phytogenic, Blacks, Cell Line, Cell Proliferation, Etoposide, Gene Expression Regulation, Genetic Variation, Humans, Inhibitory Concentration 50, Linear Models, Oligonucleotide Array Sequence Analysis, Oncogenes, Oxazines, Pharmacogenetics, Polymorphism, Single Nucleotide, Whites, Xanthenes
Added February 22, 2016
0 Communities
1 Members
0 Resources
17 MeSH Terms
A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors.
Hemstapat K, Da Costa H, Nong Y, Brady AE, Luo Q, Niswender CM, Tamagnan GD, Conn PJ
(2007) J Pharmacol Exp Ther 322: 254-64
MeSH Terms: Allosteric Regulation, Amino Acids, Animals, Binding Sites, CHO Cells, Cricetinae, Cricetulus, Humans, Male, Pyridines, Rats, Rats, Sprague-Dawley, Receptors, Metabotropic Glutamate, Structure-Activity Relationship, Sulfonamides, Xanthenes
Added February 19, 2015
0 Communities
2 Members
0 Resources
16 MeSH Terms