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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 12

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Bacterial CagA protein compromises tumor suppressor mechanisms in gastric epithelial cells.
Palrasu M, Zaika E, El-Rifai W, Garcia-Buitrago M, Piazuelo MB, Wilson KT, Peek RM, Zaika AI
(2020) J Clin Invest 130: 2422-2434
MeSH Terms: Antigens, Bacterial, Apoptosis Regulatory Proteins, Bacterial Proteins, Epithelial Cells, Gastric Mucosa, HCT116 Cells, Helicobacter pylori, Humans, Neoplasm Proteins, Proteolysis, Stomach Neoplasms, Ubiquitination, X-Linked Inhibitor of Apoptosis Protein
Added April 7, 2020
0 Communities
1 Members
0 Resources
13 MeSH Terms
Phosphorylation of XIAP at threonine 180 controls its activity in Wnt signaling.
Ng VH, Hang BI, Sawyer LM, Neitzel LR, Crispi EE, Rose KL, Popay TM, Zhong A, Lee LA, Tansey WP, Huppert S, Lee E
(2018) J Cell Sci 131:
MeSH Terms: Amino Acid Motifs, Animals, Apoptosis Regulatory Proteins, Cell Line, Glycogen Synthase Kinase 3, Humans, Intracellular Signaling Peptides and Proteins, Mitochondrial Proteins, Phosphorylation, Protein Binding, Threonine, Wnt Signaling Pathway, Wnt3A Protein, X-Linked Inhibitor of Apoptosis Protein, Xenopus
Added July 6, 2018
0 Communities
2 Members
0 Resources
15 MeSH Terms
XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling.
Hanson AJ, Wallace HA, Freeman TJ, Beauchamp RD, Lee LA, Lee E
(2012) Mol Cell 45: 619-28
MeSH Terms: Animals, Co-Repressor Proteins, Drosophila, Drosophila Proteins, Embryo, Nonmammalian, HEK293 Cells, Humans, Inhibitor of Apoptosis Proteins, Models, Genetic, RNA Interference, Ubiquitination, Wnt Proteins, Wnt Signaling Pathway, Wnt1 Protein, X-Linked Inhibitor of Apoptosis Protein, Xenopus, Xenopus Proteins
Added June 14, 2013
2 Communities
4 Members
0 Resources
17 MeSH Terms
S100A8/9 induces cell death via a novel, RAGE-independent pathway that involves selective release of Smac/DIABLO and Omi/HtrA2.
Ghavami S, Kerkhoff C, Chazin WJ, Kadkhoda K, Xiao W, Zuse A, Hashemi M, Eshraghi M, Schulze-Osthoff K, Klonisch T, Los M
(2008) Biochim Biophys Acta 1783: 297-311
MeSH Terms: Animals, Apoptosis Regulatory Proteins, Calgranulin A, Calgranulin B, Cell Death, Cell Line, Tumor, Down-Regulation, Dynamins, Fas-Associated Death Domain Protein, High-Temperature Requirement A Serine Peptidase 2, Humans, Intracellular Signaling Peptides and Proteins, Mice, Mitochondria, Mitochondrial Proteins, Protein Binding, Protein Processing, Post-Translational, Receptor for Advanced Glycation End Products, Receptors, Immunologic, Serine Endopeptidases, Signal Transduction, X-Linked Inhibitor of Apoptosis Protein, bcl-X Protein
Added May 19, 2014
0 Communities
1 Members
0 Resources
23 MeSH Terms
Non-peptidic small molecule inhibitors of XIAP.
Park CM, Sun C, Olejniczak ET, Wilson AE, Meadows RP, Betz SF, Elmore SW, Fesik SW
(2005) Bioorg Med Chem Lett 15: 771-5
MeSH Terms: Binding Sites, Drug Design, Heterocyclic Compounds, Humans, Imidazoles, Ligands, Magnetic Resonance Spectroscopy, Proteins, Structure-Activity Relationship, Thiazoles, X-Linked Inhibitor of Apoptosis Protein
Added March 5, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
Oost TK, Sun C, Armstrong RC, Al-Assaad AS, Betz SF, Deckwerth TL, Ding H, Elmore SW, Meadows RP, Olejniczak ET, Oleksijew A, Oltersdorf T, Rosenberg SH, Shoemaker AR, Tomaselli KJ, Zou H, Fesik SW
(2004) J Med Chem 47: 4417-26
MeSH Terms: Animals, Antineoplastic Agents, Apoptosis, Apoptosis Regulatory Proteins, Binding Sites, Breast Neoplasms, Carrier Proteins, Caspases, Cell Division, Cell Line, Tumor, Humans, Intracellular Signaling Peptides and Proteins, Ligands, Mice, Mitochondrial Proteins, Peptide Fragments, Protein Structure, Tertiary, Proteins, Structure-Activity Relationship, Transplantation, Heterologous, X-Linked Inhibitor of Apoptosis Protein
Added March 5, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
Regulation of the Apaf-1/caspase-9 apoptosome by caspase-3 and XIAP.
Zou H, Yang R, Hao J, Wang J, Sun C, Fesik SW, Wu JC, Tomaselli KJ, Armstrong RC
(2003) J Biol Chem 278: 8091-8
MeSH Terms: Amino Acid Sequence, Animals, Apoptosis, Apoptotic Protease-Activating Factor 1, Caspase 3, Caspase 9, Caspase Inhibitors, Caspases, Cytochrome c Group, Enzyme Activation, Humans, Hydrolysis, Kinetics, Molecular Sequence Data, Proteins, Recombinant Proteins, Sequence Homology, Amino Acid, X-Linked Inhibitor of Apoptosis Protein
Added March 5, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
Structural biology. Controlling the caspases.
Fesik SW, Shi Y
(2001) Science 294: 1477-8
MeSH Terms: Amino Acid Motifs, Animals, Apoptosis, Apoptosis Regulatory Proteins, Binding Sites, Carrier Proteins, Caspase Inhibitors, Caspases, Crystallography, X-Ray, Cysteine Proteinase Inhibitors, Dimerization, Humans, Hydrogen Bonding, Intracellular Signaling Peptides and Proteins, Mitochondria, Mitochondrial Proteins, Protein Structure, Secondary, Protein Structure, Tertiary, Proteins, X-Linked Inhibitor of Apoptosis Protein
Added March 5, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Structural basis for the inhibition of caspase-3 by XIAP.
Riedl SJ, Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik SW, Liddington RC, Salvesen GS
(2001) Cell 104: 791-800
MeSH Terms: Carrier Proteins, Caspase 3, Caspases, Catalytic Domain, Crystallography, Mitochondrial Proteins, Molecular Sequence Data, Protein Structure, Secondary, Protein Structure, Tertiary, Proteins, Structure-Activity Relationship, Substrate Specificity, X-Linked Inhibitor of Apoptosis Protein
Added March 5, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.
Liu Z, Sun C, Olejniczak ET, Meadows RP, Betz SF, Oost T, Herrmann J, Wu JC, Fesik SW
(2000) Nature 408: 1004-8
MeSH Terms: Amino Acid Sequence, Antineoplastic Agents, Apoptosis Regulatory Proteins, Binding Sites, Carrier Proteins, Caspase 9, Caspase Inhibitors, Cloning, Molecular, Cysteine Proteinase Inhibitors, Escherichia coli, Humans, Intracellular Signaling Peptides and Proteins, Magnetic Resonance Spectroscopy, Mitochondrial Proteins, Models, Molecular, Molecular Sequence Data, Mutagenesis, Site-Directed, Protein Binding, Protein Structure, Tertiary, Proteins, Sequence Homology, Amino Acid, Structure-Activity Relationship, X-Linked Inhibitor of Apoptosis Protein
Added March 5, 2014
0 Communities
1 Members
0 Resources
23 MeSH Terms