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Results: 1 to 10 of 18

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Inflammatory cytokine TSLP stimulates platelet secretion and potentiates platelet aggregation via a TSLPR-dependent PI3K/Akt signaling pathway.
Dong J, Dong J, Lin J, Wang B, He S, Wu C, Kushwaha KK, Mohabeer N, Su Y, Fang H, Huang K, Li D
(2015) Cell Physiol Biochem 35: 160-74
MeSH Terms: Androstadienes, Animals, Blood Platelets, Carotid Artery Thrombosis, Chlorides, Chromones, Cytokines, Disease Models, Animal, Ferric Compounds, Humans, Immunoglobulins, Mice, Mice, Inbred C57BL, Mice, Knockout, Morpholines, P-Selectin, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Phosphorylation, Platelet Activation, Platelet Aggregation, Platelet Glycoprotein GPIIb-IIIa Complex, Proto-Oncogene Proteins c-akt, Receptors, Cytokine, Signal Transduction, Wortmannin
Added January 20, 2015
0 Communities
1 Members
0 Resources
26 MeSH Terms
An essential role for modulation of hyperpolarization-activated current in the development of binaural temporal precision.
Khurana S, Liu Z, Lewis AS, Rosa K, Chetkovich D, Golding NL
(2012) J Neurosci 32: 2814-23
MeSH Terms: Age Factors, Analysis of Variance, Androstadienes, Animals, Biophysical Phenomena, Bucladesine, Colforsin, Cyclic Nucleotide-Gated Cation Channels, Electric Stimulation, Enzyme Inhibitors, Female, Gene Expression Regulation, Developmental, Gerbillinae, Imidazoles, In Vitro Techniques, Ion Channel Gating, Male, Neurons, Olivary Nucleus, Patch-Clamp Techniques, Pyridines, Pyrimidines, Wortmannin
Added April 2, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
(2008) J Biol Chem 283: 26538-47
MeSH Terms: Androstadienes, Animals, Cell Polarity, Chemotaxis, GTPase-Activating Proteins, Guanine Nucleotide Exchange Factors, HL-60 Cells, Humans, Interleukin-8, Mice, Mice, Knockout, Nerve Tissue Proteins, Neutrophils, Phosphatidylinositol 3-Kinases, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-hck, Pyrimidines, Receptors, Interleukin-8B, Signal Transduction, Wortmannin, rac GTP-Binding Proteins, src-Family Kinases
Added May 30, 2013
2 Communities
4 Members
0 Resources
22 MeSH Terms
Microfluidic switching system for analyzing chemotaxis responses of wortmannin-inhibited HL-60 cells.
Liu Y, Sai J, Richmond A, Wikswo JP
(2008) Biomed Microdevices 10: 499-507
MeSH Terms: Androstadienes, Cell Differentiation, Cell Movement, Cell Shape, Chemotaxis, Culture Media, Serum-Free, Dimethyl Sulfoxide, Enzyme Inhibitors, Equipment Design, HL-60 Cells, Humans, Microfluidics, Phosphoinositide-3 Kinase Inhibitors, Receptors, Interleukin-8B, Solutions, Solvents, Temperature, Time Factors, Transfection, Wortmannin
Added May 30, 2013
2 Communities
3 Members
0 Resources
20 MeSH Terms
Retroinfusion of embryonic endothelial progenitor cells attenuates ischemia-reperfusion injury in pigs: role of phosphatidylinositol 3-kinase/AKT kinase.
Kupatt C, Hinkel R, Lamparter M, von Brühl ML, Pohl T, Horstkotte J, Beck H, Müller S, Delker S, Gildehaus FJ, Büning H, Hatzopoulos AK, Boekstegers P
(2005) Circulation 112: I117-22
MeSH Terms: Androstadienes, Animals, Apoptosis, Cell Hypoxia, Cells, Cultured, Coronary Vessels, Fetal Tissue Transplantation, Heart Ventricles, Hematopoietic Stem Cell Transplantation, Infusions, Intravenous, Jugular Veins, Mice, Myocardial Infarction, Myocardial Ischemia, Myocardial Reperfusion Injury, Myocytes, Cardiac, Peroxidase, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Pressure, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-akt, Radiopharmaceuticals, Rats, Sus scrofa, Technetium Tc 99m Exametazime, Transplantation, Heterologous, Wortmannin
Added November 18, 2010
1 Communities
1 Members
0 Resources
28 MeSH Terms
Phosphatidylinositol 3-kinase/Akt signaling in the response of vascular endothelium to ionizing radiation.
Edwards E, Geng L, Tan J, Onishko H, Donnelly E, Hallahan DE
(2002) Cancer Res 62: 4671-7
MeSH Terms: Androstadienes, Animals, Apoptosis, Cell Survival, Cells, Cultured, Chromones, Endothelium, Vascular, Enzyme Inhibitors, Glioblastoma, Humans, Mice, Mice, Inbred C57BL, Morpholines, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Phosphorylation, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-akt, Signal Transduction, Wortmannin
Added February 28, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
In vivo intracellular signaling as a marker of antiangiogenic activity.
Solorzano CC, Jung YD, Bucana CD, McConkey DJ, Gallick GE, McMahon G, Ellis LM
(2001) Cancer Res 61: 7048-51
MeSH Terms: Androstadienes, Angiogenesis Inhibitors, Biomarkers, Tumor, Blotting, Western, Endothelial Growth Factors, Endothelium, Vascular, Enzyme Activation, Enzyme Inhibitors, Flavonoids, Fluorescent Antibody Technique, Humans, Indoles, Liver Neoplasms, Lymphokines, MAP Kinase Signaling System, Mitogen-Activated Protein Kinase Kinases, Neovascularization, Pathologic, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Phosphorylation, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-akt, Pyrroles, Receptor Protein-Tyrosine Kinases, Receptors, Growth Factor, Receptors, Vascular Endothelial Growth Factor, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factors, Wortmannin
Added March 5, 2014
0 Communities
1 Members
0 Resources
30 MeSH Terms
Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation.
Vieira OV, Botelho RJ, Rameh L, Brachmann SM, Matsuo T, Davidson HW, Schreiber A, Backer JM, Cantley LC, Grinstein S
(2001) J Cell Biol 155: 19-25
MeSH Terms: Androstadienes, Animals, Cells, Cultured, Enzyme Inhibitors, Fibroblasts, Genes, Reporter, Humans, Immunoglobulin G, Isoenzymes, Lysosomes, Macrophages, Mice, Mice, Knockout, Microinjections, Phagocytosis, Phagosomes, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Protein Structure, Tertiary, Recombinant Fusion Proteins, Wortmannin
Added December 10, 2018
0 Communities
1 Members
0 Resources
21 MeSH Terms
The p38 MAPK pathway mediates the growth inhibitory effects of interferon-alpha in BCR-ABL-expressing cells.
Mayer IA, Verma A, Grumbach IM, Uddin S, Lekmine F, Ravandi F, Majchrzak B, Fujita S, Fish EN, Platanias LC
(2001) J Biol Chem 276: 28570-7
MeSH Terms: Androstadienes, Cell Division, Cell Line, Dose-Response Relationship, Drug, Electrophoresis, Polyacrylamide Gel, Enzyme Activation, Enzyme Inhibitors, Fusion Proteins, bcr-abl, Genistein, Humans, Imidazoles, Immunoblotting, Interferon-alpha, Intracellular Signaling Peptides and Proteins, K562 Cells, MAP Kinase Signaling System, Mitogen-Activated Protein Kinases, Phosphorylation, Protein-Serine-Threonine Kinases, Pyridines, Tyrosine, Wortmannin, p38 Mitogen-Activated Protein Kinases
Added March 5, 2014
0 Communities
1 Members
0 Resources
23 MeSH Terms
Induction of the C/EBP homologous protein (CHOP) by amino acid deprivation requires insulin-like growth factor I, phosphatidylinositol 3-kinase, and mammalian target of rapamycin signaling.
Entingh AJ, Law BK, Moses HL
(2001) Endocrinology 142: 221-8
MeSH Terms: 3T3 Cells, Amino Acids, Androstadienes, Animals, Arsenites, CCAAT-Enhancer-Binding Proteins, Calcimycin, Cell Line, Chromones, Culture Media, Dimerization, Enzyme Inhibitors, Gene Expression Regulation, Hydrogen Peroxide, Insulin-Like Growth Factor I, Mammals, Mice, Morpholines, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Signal Transduction, Sirolimus, Sodium Compounds, Transcription Factor CHOP, Transcription Factors, Transcription, Genetic, Wortmannin
Added February 17, 2014
0 Communities
1 Members
0 Resources
27 MeSH Terms