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The Role of Mitochondrial DNA Variation in Age-Related Decline in Gait Speed Among Older Men Living With Human Immunodeficiency Virus.
Sun J, Brown TT, Samuels DC, Hulgan T, D'Souza G, Jamieson BD, Erlandson KM, Martinson J, Palella FJ, Margolick JB, Kirk GD, Schrack JA
(2018) Clin Infect Dis 67: 778-784
MeSH Terms: Age Factors, Aging, Body Composition, Cohort Studies, DNA, Mitochondrial, Genetic Variation, HIV Infections, Haplotypes, Humans, Logistic Models, Male, Middle Aged, Odds Ratio, Risk Factors, Sexual and Gender Minorities, Walking Speed
Show Abstract · Added March 21, 2018
Background - Age-related gait speed decline is accelerated in men with human immunodeficiency virus (HIV). Mitochondrial genetic variation is associated with frailty and mortality in the general population and may provide insight into mechanisms of functional decline in people aging with HIV.
Methods - Gait speed was assessed semiannually in the Multicenter AIDS Cohort Study. Mitochondrial DNA (mtDNA) haplogroups were extracted from genome-wide genotyping data, classifying men aged ≥50 years into 5 groups: mtDNA haplogroup H, J, T, Uk, and other. Differences in gait speed by haplogroups were assessed as rate of gait speed decline per year, probability of slow gait speed (<1.0 m/s), and hazard of slow gait using multivariable linear mixed-effects models, mixed-effects logistic regression models, and the Andersen-Gill model, controlling for hepatitis C virus infection, previous AIDS diagnosis, thymidine analogues exposure, education, body composition, smoking, and peripheral neuropathy. Age was further controlled for in the mixed-effects logistic regression models.
Results - A total of 455 HIV-positive white men aged ≥50 years contributed 3283 person-years of follow-up. Among them, 70% had achieved HIV viral suppression. In fully adjusted models, individuals with haplogroup J had more rapid decline in gait speed (adjusted slopes, 0.018 m/s/year vs 0.011 m/s/year, pinteraction = 0.012) and increased risk of developing slow gait (adjusted odds ratio, 2.97; 95% confidence interval, 1.24-7.08) compared to those with other haplogroups.
Conclusions - Among older, HIV-infected men, mtDNA haplogroup J was an independent risk factor for more rapid age-related gait speed decline.
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16 MeSH Terms
Walking and Calcified Atherosclerotic Plaque in the Coronary Arteries: The National Heart, Lung, and Blood Institute Family Heart Study.
Imran TF, Patel Y, Ellison RC, Carr JJ, Arnett DK, Pankow JS, Heiss G, Hunt SC, Gaziano JM, Djoussé L
(2016) Arterioscler Thromb Vasc Biol 36: 1272-7
MeSH Terms: Adult, Aged, Aortic Diseases, Aortography, Computed Tomography Angiography, Coronary Angiography, Coronary Artery Disease, Coronary Vessels, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Multidetector Computed Tomography, National Heart, Lung, and Blood Institute (U.S.), Plaque, Atherosclerotic, Prevalence, Protective Factors, Risk Assessment, Risk Factors, Risk Reduction Behavior, Surveys and Questionnaires, United States, Vascular Calcification, Walking
Show Abstract · Added September 29, 2016
OBJECTIVE - Studies have reported mixed findings on the association between physical activity and subclinical atherosclerosis. We sought to examine whether walking is associated with prevalent coronary artery calcification (CAC) and aortic calcification.
APPROACH AND RESULTS - In a cross-sectional design, we studied 2971 participants of the National Heart, Lung, and Blood Institute Family Heart Study without a history of myocardial infarction, coronary artery bypass grafting, or percutaneous transluminal angioplasty. A standardized questionnaire was used to ascertain the number of blocks walked daily to compute walking metabolic equivalent hours. CAC was measured by cardiac computed tomography. We defined prevalent CAC and aortic calcification using an Agatston score of at least 100 and used generalized estimating equations to calculate adjusted prevalence ratios. Mean age was 55 years, and 60% of participants were women. Compared with the ≤3.75-Met-h/wk group, prevalence ratios for CAC after adjusting for age, sex, race, smoking, alcohol use, total physical activity (excluding walking), and familial clustering were 0.53 (95% confidence interval, 0.35-0.79) for >3.75 to 7.5 Met-h/wk, 0.72 (95% confidence interval, 0.52-0.99) for >7.5 to 15 Met-h/wk, and 0.54 (95% confidence interval, 0.36-0.81) for >15 to 22.5 Met-h/wk, (P trend=0.01). The walking-CAC relationship remained significant for those with body mass index ≥25 (P trend=0.02) and persisted with CAC cutoffs of 300, 200, 150, and 50 but not 0. When examined as a continuous variable, a J-shaped association between walking and CAC was found. The walking-aortic calcification association was not significant.
CONCLUSIONS - Our findings suggest that walking is associated with lower prevalent CAC (but not aortic calcification) in adults without known heart disease.
© 2016 American Heart Association, Inc.
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25 MeSH Terms
Lower gray matter integrity is associated with greater lap time variation in high-functioning older adults.
Tian Q, Resnick SM, Landman BA, Huo Y, Venkatraman VK, Gonzalez CE, Simonsick EM, Shardell MD, Ferrucci L, Studenski SA
(2016) Exp Gerontol 77: 46-51
MeSH Terms: Aged, Aged, 80 and over, Aging, Cross-Sectional Studies, Diffusion Magnetic Resonance Imaging, Female, Gray Matter, Humans, Male, Middle Aged, Walking
Show Abstract · Added November 2, 2016
BACKGROUND - Lower integrity of cerebral gray matter is associated with higher gait variability. It is not known whether gray matter integrity is associated with higher lap time variation (LTV), a clinically accessible measure of gait variability, high levels of which have been associated with mortality. This study examines the cross-sectional association between gray matter mean diffusivity (MD) and LTV in community-dwelling older adults.
METHODS - Study participants consisted of 449 high-functioning adults aged 50 and older (56.8% female) in the Baltimore Longitudinal Study of Aging, free of overt neurological disease. The magnitude of MD in the gray matter, a measure of impaired tissue integrity, was assessed by diffusion tensor imaging in 16 regions of interest (ROIs) involved with executive function, sensorimotor function, and memory. LTV was assessed as variability in lap time based on individual trajectories over ten 40-m laps. Age, sex, height, and weight were covariates. The model additionally adjusted for mean lap time and health conditions that may affect LTV.
RESULTS - Higher levels of average MD across 16 ROIs were significantly associated with higher LTV after adjustment for covariates. Specifically, higher MD in the precuneus and the anterior and middle cingulate cortices was strongly associated with higher LTV, as compared to other ROIs. The association persisted after adjustment for mean lap time, hypertension, and diabetes.
CONCLUSIONS - Lower gray matter integrity in selected areas may underlie greater LTV in high-functioning community-dwelling older adults. Longitudinal studies are warranted to examine whether changes in gray matter integrity precede more variable gait.
Published by Elsevier Inc.
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11 MeSH Terms
The effect of social integration on outcomes after major lower extremity amputation.
Hawkins AT, Pallangyo AJ, Herman AM, Schaumeier MJ, Smith AD, Hevelone ND, Crandell DM, Nguyen LL
(2016) J Vasc Surg 63: 154-62
MeSH Terms: Adult, Aged, Aged, 80 and over, Amputation, Amputees, Boston, Chi-Square Distribution, Cross-Sectional Studies, Exercise Test, Female, Humans, Linear Models, Lower Extremity, Male, Middle Aged, Mobility Limitation, Multivariate Analysis, Quality of Life, Recovery of Function, Risk Factors, Social Behavior, Social Support, Surveys and Questionnaires, Tanzania, Treatment Outcome, Walking, Young Adult
Show Abstract · Added September 27, 2016
OBJECTIVE - Major lower extremity (MLE) amputation is a common procedure that results in a profound change in a patient's life. We sought to determine the association between social support and outcomes after amputation. We hypothesized that patients with greater social support will have better post amputation outcomes.
METHODS - From November 2011 to May 2013, we conducted a cross-sectional, observational, multicenter study. Social integration was measured by the social integration subset of the Short Form Craig Handicap Assessment and Reporting Technique. Systemic social support was assessed by comparing a United States and Tanzanian population. Walking function was measured using the 6-minute walk test and quality of life (QoL) was measured using the EuroQol-5D.
RESULTS - We recruited 102 MLE amputees. Sixty-three patients were enrolled in the United States with a mean age of 58.0. Forty-two (67%) were male. Patients with low social integration were more likely to be unable to ambulate (no walk 39% vs slow walk 23% vs fast walk 10%; P = .01) and those with high social integration were more likely to be fast walkers (no walk 10% vs slow walk 59% vs fast walk 74%; P = .01). This relationship persisted in a multivariable analysis. Increasing social integration scores were also positively associated with increasing QoL scores in a multivariable analysis (β, .002; standard error, 0.0008; P = .02). In comparing the United States population with the Tanzanian cohort (39 subjects), there were no differences between functional or QoL outcomes in the systemic social support analysis.
CONCLUSIONS - In the United States population, increased social integration is associated with both improved function and QoL outcomes among MLE amputees. Systemic social support, as measured by comparing the United States population with a Tanzanian population, was not associated with improved function or QoL outcomes. In the United States, steps should be taken to identify and aid amputees with poor social integration.
Copyright © 2016 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.
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27 MeSH Terms
The effect of age and microstructural white matter integrity on lap time variation and fast-paced walking speed.
Tian Q, Ferrucci L, Resnick SM, Simonsick EM, Shardell MD, Landman BA, Venkatraman VK, Gonzalez CE, Studenski SA
(2016) Brain Imaging Behav 10: 697-706
MeSH Terms: Aged, Aging, Baltimore, Brain, Diffusion Tensor Imaging, Exercise Test, Female, Humans, Linear Models, Male, Middle Aged, Walking Speed, White Matter
Show Abstract · Added February 15, 2016
Macrostructural white matter damage (WMD) is associated with less uniform and slower walking in older adults. The effect of age and subclinical microstructural WM degeneration (a potentially earlier phase of WM ischemic damage) on walking patterns and speed is less clear. This study examines the effect of age on the associations of regional microstructural WM integrity with walking variability and speed, independent of macrostructural WMD. This study involved 493 participants (n = 51 young; n = 209 young-old; n = 233 old-old) from the Baltimore Longitudinal Study of Aging. All completed a 400-meter walk test and underwent a concurrent brain MRI with diffusion tensor imaging. Microstructural WM integrity was measured as fractional anisotropy (FA). Walking variability was measured as trend-adjusted variation in time over ten 40-meter laps (lap time variation, LTV). Fast-paced walking speed was assessed as mean lap time (MLT). Multiple linear regression models of FA predicting LTV and MLT were adjusted for age, sex, height, weight, and WM hyperintensities. Independent of WM hyperintensities, lower FA in the body of the corpus callosum was associated with higher LTV and longer MLT only in the young-old. Lower FA in superior longitudinal, inferior fronto-occipital, and uncinate fasciculi, the anterior limb of the internal capsule, and the anterior corona radiate was associated with longer MLT only in the young-old. While macrostructural WMD is known to predict more variable and slower walking in older adults, microstructural WM disruption is independently associated with more variable and slower fast-paced walking only in the young-old. Disrupted regional WM integrity may be a subclinical contributor to abnormal walking at an earlier phase of aging.
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13 MeSH Terms
Low Physical Function in Maintenance Hemodialysis Patients Is Independent of Muscle Mass and Comorbidity.
Marcus RL, LaStayo PC, Ikizler TA, Wei G, Giri A, Chen X, Morrell G, Painter P, Beddhu S
(2015) J Ren Nutr 25: 371-5
MeSH Terms: Aged, Comorbidity, Diabetes Mellitus, Female, Heart Diseases, Humans, Kidney Failure, Chronic, Lung Diseases, Magnetic Resonance Imaging, Male, Middle Aged, Muscular Atrophy, Renal Dialysis, Thigh, Vascular Diseases, Walking
Show Abstract · Added August 5, 2015
OBJECTIVES - It is unknown whether muscle wasting accounts for impaired physical function in adults on maintenance hemodialysis (MHD).
DESIGN - Observational study.
SETTING - Outpatient dialysis units and a fall clinic.
SUBJECTS - One hundred eight MHD and 122 elderly nonhemodialysis (non-HD) participants.
EXPOSURE VARIABLE - Mid-thigh muscle area was measured by magnetic resonance imaging.
MAIN OUTCOME MEASURE - Physical function was measured by distance walked in 6 minutes.
RESULTS - Compared with non-HD elderly participants, MHD participants were younger (49.2 ± 15.8 vs. 75.3 ± 7.1 years; P < .001) and had higher mid-thigh muscle area (106.2 ± 26.8 vs. 96.1 ± 21.1 cm2; P = .002). However, the distance walked in 6 minutes was lower in MHD participants (322.9 ± 110.4 vs. 409.0 ± 128.3 m; P < .001). In multiple regression analysis adjusted for demographics, comorbid conditions, and mid-thigh muscle area, MHD patients walked significantly less distance (-117 m; 95% confidence interval: -177 to -56 m; P < .001) than the non-HD elderly.
CONCLUSIONS - Even when compared with elderly non-HD participants, younger MHD participants have poorer physical function that was not explained by muscle mass or comorbid conditions. We speculate that the uremic milieu may impair muscle function independent of muscle mass. The mechanism of impaired muscle function in uremia needs to be established in future studies.
Published by Elsevier Inc.
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16 MeSH Terms
Evaluation of an exercise field test using heart rate monitors to assess cardiorespiratory fitness and heart rate recovery in an asymptomatic population.
Coolbaugh CL, Anderson IB, Wilson MD, Hawkins DA, Amsterdam EA
(2014) PLoS One 9: e97704
MeSH Terms: Adolescent, Adult, Asymptomatic Diseases, Exercise Test, Exercise Tolerance, Female, Heart Rate, Humans, Male, Middle Aged, Respiratory Physiological Phenomena, Running, Walking, Young Adult
Show Abstract · Added September 15, 2014
PURPOSE - Measures of cardiorespiratory fitness (CRF) and heart rate recovery (HRR) can improve risk stratification for cardiovascular disease, but these measurements are rarely made in asymptomatic individuals due to cost. An exercise field test (EFT) to assess CRF and HRR would be an inexpensive method for cardiovascular disease risk assessment in large populations. This study assessed 1) the predictive accuracy of a 12-minute run/walk EFT for estimating CRF ([Formula: see text]) and 2) the accuracy of HRR measured after an EFT using a heart rate monitor (HRM) in an asymptomatic population.
METHODS - Fifty subjects (48% women) ages 18-45 years completed a symptom-limited exercise tolerance test (ETT) (Bruce protocol) and an EFT on separate days. During the ETT, [Formula: see text] was measured by a metabolic cart, and heart rate was measured continuously by a HRM and a metabolic cart.
RESULTS - EFT distance and sex independently predicted[Formula: see text]. The average absolute difference between observed and predicted [Formula: see text] was 0.26 ± 3.27 ml·kg-1·min-1 for our model compared to 7.55 ± 3.64 ml·kg-1·min-1 for the Cooper model. HRM HRR data were equivalent to respective metabolic cart values during the ETT. HRR at 1 minute post-exercise during ETT compared to the EFT had a moderate correlation (r=0.75, p<0.001).
CONCLUSION - A more accurate model to estimate CRF from a 12-minute run/walk EFT was developed, and HRR can be measured using a HRM in an asymptomatic population outside of clinical settings.
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14 MeSH Terms
Nonexercise physical activity and inflammatory and oxidative stress markers in women.
Wu SH, Shu XO, Chow WH, Xiang YB, Zhang X, Li HL, Cai Q, Milne G, Ji BT, Cai H, Rothman N, Gao YT, Zheng W, Yang G
(2014) J Womens Health (Larchmt) 23: 159-67
MeSH Terms: Adult, Aged, Analysis of Variance, Biomarkers, C-Reactive Protein, China, Cross-Sectional Studies, Cytokines, F2-Isoprostanes, Female, Humans, Inflammation, Interleukin-6, Interviews as Topic, Middle Aged, Motor Activity, Multivariate Analysis, Oxidative Stress, Physical Exertion, Socioeconomic Factors, Tumor Necrosis Factor-alpha, Walking
Show Abstract · Added March 7, 2014
BACKGROUND - Leisure time exercise has been linked to lower circulating levels of inflammatory markers. Few studies have examined the association of nonexercise physical activity with markers of inflammation and oxidative stress.
METHODS - This cross-sectional analysis included 1005 Chinese women aged 40-70 years. Usual physical activity was assessed through in-person interviews using a validated physical activity questionnaire. Plasma proinflammatory cytokines and urinary F2-isoprostanes were measured. Multivariable linear models were used to evaluate the association of inflammatory and oxidative stress markers with nonexercise physical activity and its major components.
RESULTS - Nonexercise physical activity accounted for 93.8% of overall physical activity energy expenditure. Levels of nonexercise physical activity were inversely associated with circulating concentrations of interleukin (IL)-6 (Ptrend=0.004), IL-1β (Ptrend=0.03) and tumor necrosis factor-alpha (TNF-α) (Ptrend=0.01). Multivariable-adjusted concentrations of these cytokines were 28.2% for IL-6, 22.1% for IL-1β, and 15.9% for TNF-α lower in the highest quartile of nonexercise physical activity compared with the lowest quartile. Similar inverse associations were found for two major components of nonexercise physical activity, walking and biking for transportation, and household activity. No significant associations were observed between nonexercise physical activity and oxidative stress markers.
CONCLUSION - Daily nonexercise physical activity is associated with lower levels of systemic inflammation. This finding may have important public health implications because this type of activity is the main contributor to overall physical activity among middle-aged and elderly women.
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22 MeSH Terms
Associations of Tai Chi, walking, and jogging with mortality in Chinese men.
Wang N, Zhang X, Xiang YB, Li H, Yang G, Gao J, Zheng W, Shu XO
(2013) Am J Epidemiol 178: 791-6
MeSH Terms: Adult, Aged, Alcohol Drinking, Body Mass Index, China, Chronic Disease, Exercise, Humans, Jogging, Male, Middle Aged, Mortality, Occupations, Prospective Studies, Smoking, Tai Ji, Walking
Show Abstract · Added March 7, 2014
Moderate-intensity exercise has attracted considerable attention because of its safety and many health benefits. Tai Chi, a form of mind-body exercise that originated in ancient China, has been gaining popularity. Practicing Tai Chi may improve overall health and well-being; however, to our knowledge, no study has evaluated its relationship with mortality. We assessed the associations of regular exercise and specifically participation in Tai Chi, walking, and jogging with total and cause-specific mortality among 61,477 Chinese men in the Shanghai Men's Health Study (2002-2009). Information on exercise habits was obtained at baseline using a validated physical activity questionnaire. Deaths were ascertained through biennial home visits and linkage with a vital statistics registry. During a mean follow-up of 5.48 years, 2,421 deaths were identified. After adjustment for potential confounders, men who exercised regularly had a hazard ratio for total mortality of 0.80 (95% confidence interval: 0.74, 0.87) compared with men who did not exercise. The corresponding hazard ratios were 0.80 (95% confidence interval: 0.72, 0.89) for practicing Tai Chi, 0.77 (95% confidence interval: 0.69, 0.86) for walking, and 0.73 (95% confidence interval: 0.59, 0.90) for jogging. Similar inverse associations were also found for cancer and cardiovascular mortality. The present study provides the first evidence that, like walking and jogging, practicing Tai Chi is associated with reduced mortality.
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17 MeSH Terms
Association between physical performance and all-cause mortality in CKD.
Roshanravan B, Robinson-Cohen C, Patel KV, Ayers E, Littman AJ, de Boer IH, Ikizler TA, Himmelfarb J, Katzel LI, Kestenbaum B, Seliger S
(2013) J Am Soc Nephrol 24: 822-30
MeSH Terms: Adult, Aged, Female, Gait, Glomerular Filtration Rate, Hand Strength, Humans, Male, Middle Aged, Proportional Hazards Models, Renal Insufficiency, Chronic, Walking
Show Abstract · Added August 15, 2013
In older adults, measurements of physical performance assess physical function and associate with mortality and disability. Muscle wasting and diminished physical performance often accompany CKD, resembling physiologic aging, but whether physical performance associates with clinical outcome in CKD is unknown. We evaluated 385 ambulatory, stroke-free participants with stage 2-4 CKD enrolled in clinic-based cohorts at the University of Washington and University of Maryland and Veterans Affairs Maryland Healthcare systems. We compared handgrip strength, usual gait speed, timed up and go (TUAG), and 6-minute walking distance with normative values and constructed Cox proportional hazards models and receiver operating characteristic curves to test associations with all-cause mortality. Mean age was 61 years and the mean estimated GFR was 41 ml/min per 1.73 m(2). Measures of lower extremity performance were at least 30% lower than predicted, but handgrip strength was relatively preserved. Fifty deaths occurred during the median 3-year follow-up period. After adjustment, each 0.1-m/s decrement in gait speed associated with a 26% higher risk for death, and each 1-second longer TUAG associated with an 8% higher risk for death. On the basis of the receiver operating characteristic analysis, gait speed and TUAG more strongly predicted 3-year mortality than kidney function or commonly measured serum biomarkers. Adding gait speed to a model that included estimated GFR significantly improved the prediction of 3-year mortality. In summary, impaired physical performance of the lower extremities is common in CKD and strongly associates with all-cause mortality.
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12 MeSH Terms