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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Histone deacetylase inhibitor treatment induces 'BRCAness' and synergistic lethality with PARP inhibitor and cisplatin against human triple negative breast cancer cells.
Ha K, Fiskus W, Choi DS, Bhaskara S, Cerchietti L, Devaraj SG, Shah B, Sharma S, Chang JC, Melnick AM, Hiebert S, Bhalla KN
(2014) Oncotarget 5: 5637-50
MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Apoptosis, Ataxia Telangiectasia Mutated Proteins, BRCA1 Protein, Cell Line, Tumor, Checkpoint Kinase 1, Cisplatin, DNA Damage, Drug Synergism, Enzyme Inhibitors, Female, Gene Knockdown Techniques, HSP90 Heat-Shock Proteins, HeLa Cells, Histone Deacetylase Inhibitors, Humans, Hydroxamic Acids, Indoles, MCF-7 Cells, Mice, Panobinostat, Poly(ADP-ribose) Polymerase Inhibitors, Protein Kinases, Reactive Oxygen Species, Triple Negative Breast Neoplasms, Vorinostat, Xenograft Model Antitumor Assays
Added September 28, 2015
0 Communities
1 Members
0 Resources
28 MeSH Terms
Suberoylanilide hydroxamic acid (SAHA) enhances olaparib activity by targeting homologous recombination DNA repair in ovarian cancer.
Konstantinopoulos PA, Wilson AJ, Saskowski J, Wass E, Khabele D
(2014) Gynecol Oncol 133: 599-606
MeSH Terms: Animals, Antineoplastic Agents, Carcinoma, Ovarian Epithelial, Cell Line, Tumor, Cell Proliferation, Cell Survival, DNA Damage, DNA, Neoplasm, Down-Regulation, Drug Resistance, Neoplasm, Drug Synergism, Female, Histone Deacetylase Inhibitors, Humans, Hydroxamic Acids, Mice, Mice, Nude, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Phthalazines, Piperazines, Recombinational DNA Repair, Tissue Array Analysis, Vorinostat, Xenograft Model Antitumor Assays
Added March 28, 2014
0 Communities
3 Members
0 Resources
25 MeSH Terms
STAT6 activation in ulcerative colitis: a new target for prevention of IL-13-induced colon epithelial cell dysfunction.
Rosen MJ, Frey MR, Washington MK, Chaturvedi R, Kuhnhein LA, Matta P, Revetta FL, Wilson KT, Polk DB
(2011) Inflamm Bowel Dis 17: 2224-34
MeSH Terms: Apoptosis, Blotting, Western, Case-Control Studies, Cells, Cultured, Child, Claudins, Colitis, Ulcerative, Colon, Crohn Disease, Epithelial Cells, Female, Humans, Hydroxamic Acids, Immunoenzyme Techniques, Interleukin-13, Male, Phosphorylation, RNA, Messenger, RNA, Small Interfering, Real-Time Polymerase Chain Reaction, STAT6 Transcription Factor, Signal Transduction, Up-Regulation, Vorinostat
Added March 5, 2014
0 Communities
3 Members
0 Resources
24 MeSH Terms
Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: implications for therapy.
Khabele D, Son DS, Parl AK, Goldberg GL, Augenlicht LH, Mariadason JM, Rice VM
(2007) Cancer Biol Ther 6: 795-801
MeSH Terms: Acetylation, Adult, Aged, Antibiotics, Antineoplastic, Blotting, Western, Butyrates, Carcinoma, Papillary, Cell Proliferation, Cystadenocarcinoma, Serous, Depsipeptides, Disease Progression, Enzyme Inhibitors, Female, Gene Expression Regulation, Enzymologic, Gene Silencing, Histone Deacetylase 1, Histone Deacetylases, Humans, Hydroxamic Acids, Middle Aged, Ovarian Neoplasms, RNA, Small Interfering, Transcription, Genetic, Tumor Cells, Cultured, Tumor Stem Cell Assay, Vorinostat
Added March 5, 2014
0 Communities
1 Members
0 Resources
26 MeSH Terms