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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 65

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The 2019 Nobel Prize honors fundamental discoveries in hypoxia response.
Moslehi J, Rathmell WK
(2020) J Clin Invest 130: 4-6
MeSH Terms: Cell Hypoxia, History, 20th Century, Humans, Hypoxia-Inducible Factor 1, alpha Subunit, Nobel Prize, Vascular Endothelial Growth Factor A, Von Hippel-Lindau Tumor Suppressor Protein
Added November 27, 2019
0 Communities
2 Members
0 Resources
7 MeSH Terms
Hypoxia, angiogenesis, and metabolism in the hereditary kidney cancers.
Chappell JC, Payne LB, Rathmell WK
(2019) J Clin Invest 129: 442-451
MeSH Terms: Carcinoma, Renal Cell, Cell Hypoxia, Genetic Diseases, Inborn, Humans, Kidney Neoplasms, Leiomyomatosis, Models, Biological, Mutation, Neoplastic Syndromes, Hereditary, Neovascularization, Pathologic, Von Hippel-Lindau Tumor Suppressor Protein
Added October 30, 2019
0 Communities
1 Members
0 Resources
11 MeSH Terms
VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma.
Zhang J, Wu T, Simon J, Takada M, Saito R, Fan C, Liu XD, Jonasch E, Xie L, Chen X, Yao X, Teh BT, Tan P, Zheng X, Li M, Lawrence C, Fan J, Geng J, Liu X, Hu L, Wang J, Liao C, Hong K, Zurlo G, Parker JS, Auman JT, Perou CM, Rathmell WK, Kim WY, Kirschner MW, Kaelin WG, Baldwin AS, Zhang Q
(2018) Science 361: 290-295
MeSH Terms: Animals, Carcinoma, Renal Cell, Chromatin Immunoprecipitation, Female, Gene Expression Regulation, Neoplastic, Homeodomain Proteins, Humans, Hydroxylation, Kidney Neoplasms, Mice, Mice, SCID, Molecular Targeted Therapy, Mutation, NF-kappa B, Oncogenes, Substrate Specificity, Transcription Factors, Von Hippel-Lindau Tumor Suppressor Protein
Added October 30, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
High Frequency of Ovarian Cyst Development in Vhl;Snf5 Mice.
Kuwahara Y, Kennedy LM, Karnezis AN, Mora-Blanco EL, Rogers AB, Fletcher CD, Huntsman DG, Roberts CWM, Rathmell WK, Weissman BE
(2018) Am J Pathol 188: 1510-1516
MeSH Terms: Animals, Female, Hemorrhage, Mice, Mice, Knockout, Mutation, Ovarian Cysts, Phenotype, SMARCB1 Protein, Von Hippel-Lindau Tumor Suppressor Protein
Added October 30, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Von Hippel-Lindau mutations disrupt vascular patterning and maturation via Notch.
Arreola A, Payne LB, Julian MH, de Cubas AA, Daniels AB, Taylor S, Zhao H, Darden J, Bautch VL, Rathmell WK, Chappell JC
(2018) JCI Insight 3:
MeSH Terms: Animals, Diamines, Disease Models, Animal, Endothelial Cells, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Hemangioblastoma, Humans, Male, Mice, Mice, Transgenic, Microvessels, Mutation, Receptors, Notch, Retinal Artery, Thiazoles, Von Hippel-Lindau Tumor Suppressor Protein, von Hippel-Lindau Disease
Added October 30, 2019
0 Communities
2 Members
0 Resources
19 MeSH Terms
Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin.
Farsijani NM, Liu Q, Kobayashi H, Davidoff O, Sha F, Fandrey J, Ikizler TA, O'Connor PM, Haase VH
(2016) J Clin Invest 126: 1425-37
MeSH Terms: Animals, Epithelium, Erythropoiesis, Erythropoietin, Glucose, Kidney Tubules, Proximal, Mice, Mice, Transgenic, Oxygen Consumption, Transcription Factors, Von Hippel-Lindau Tumor Suppressor Protein
Added April 20, 2016
0 Communities
1 Members
0 Resources
11 MeSH Terms
HIF targets in bone remodeling and metastatic disease.
Johnson RW, Schipani E, Giaccia AJ
(2015) Pharmacol Ther 150: 169-77
MeSH Terms: Antineoplastic Agents, Bone Development, Bone Neoplasms, Bone Remodeling, Cell Hypoxia, Humans, Hypoxia-Inducible Factor 1, Molecular Targeted Therapy, Prolyl Hydroxylases, Tumor Microenvironment, Von Hippel-Lindau Tumor Suppressor Protein
Added March 26, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Activation of hypoxia-inducible factor-2 in adipocytes results in pathological cardiac hypertrophy.
Lin Q, Huang Y, Booth CJ, Haase VH, Johnson RS, Celeste Simon M, Giordano FJ, Yun Z
(2013) J Am Heart Assoc 2: e000548
MeSH Terms: Adipocytes, Animals, Basic Helix-Loop-Helix Transcription Factors, Cardiomegaly, Cytokines, Disease Models, Animal, Gene Expression Regulation, Genetic Predisposition to Disease, Hypoxia-Inducible Factor 1, alpha Subunit, Inflammation Mediators, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Myocytes, Cardiac, Phenotype, Signal Transduction, Time Factors, Von Hippel-Lindau Tumor Suppressor Protein
Added February 25, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
Pleiotropic effects of the trichloroethylene-associated P81S VHL mutation on metabolism, apoptosis, and ATM-mediated DNA damage response.
Desimone MC, Rathmell WK, Threadgill DW
(2013) J Natl Cancer Inst 105: 1355-64
MeSH Terms: Animals, Apoptosis, Arginine, Ataxia Telangiectasia Mutated Proteins, Carcinoma, Renal Cell, Cell Cycle Proteins, DNA Damage, DNA-Binding Proteins, Embryonic Stem Cells, Glutamine, Humans, Hypoxia-Inducible Factor 1, Immunohistochemistry, Kidney Neoplasms, Mice, Occupational Exposure, Point Mutation, Proline, Protein Array Analysis, Protein Serine-Threonine Kinases, Serine, Teratoma, Trichloroethylene, Tumor Suppressor Proteins, Ubiquitin-Protein Ligases, Von Hippel-Lindau Tumor Suppressor Protein
Added October 17, 2015
0 Communities
1 Members
0 Resources
26 MeSH Terms
The molecular biology of renal cell carcinoma.
Keefe SM, Nathanson KL, Rathmell WK
(2013) Semin Oncol 40: 421-8
MeSH Terms: Basic Helix-Loop-Helix Transcription Factors, Carcinoma, Renal Cell, Epigenesis, Genetic, Humans, Hypoxia-Inducible Factor 1, alpha Subunit, Kidney Neoplasms, Mutation, TOR Serine-Threonine Kinases, Tumor Suppressor Proteins, Ubiquitin Thiolesterase, Von Hippel-Lindau Tumor Suppressor Protein
Added October 17, 2015
0 Communities
1 Members
0 Resources
11 MeSH Terms