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Structural and Functional Features of the Reovirus σ1 Tail.
Dietrich MH, Ogden KM, Long JM, Ebenhoch R, Thor A, Dermody TS, Stehle T
(2018) J Virol 92:
MeSH Terms: Amino Acid Sequence, Capsid Proteins, Cells, Cultured, Crystallography, X-Ray, Protein Binding, Protein Conformation, Receptors, Virus, Reoviridae, Reoviridae Infections, Sequence Homology, Virus Attachment, Virus Internalization, Virus Replication
Added April 3, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses.
Wec AZ, Nyakatura EK, Herbert AS, Howell KA, Holtsberg FW, Bakken RR, Mittler E, Christin JR, Shulenin S, Jangra RK, Bharrhan S, Kuehne AI, Bornholdt ZA, Flyak AI, Saphire EO, Crowe JE, Aman MJ, Dye JM, Lai JR, Chandran K
(2016) Science 354: 350-354
MeSH Terms: Animals, Antibodies, Bispecific, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Binding Sites, Carrier Proteins, Cell Line, Tumor, Ebolavirus, Endosomes, Hemorrhagic Fever, Ebola, Humans, Immunotherapy, Intracellular Signaling Peptides and Proteins, Membrane Glycoproteins, Mice, Mice, Inbred BALB C, Niemann-Pick C1 Protein, Receptors, Virus, Viral Envelope Proteins, Virus Internalization
Added April 13, 2017
0 Communities
1 Members
0 Resources
21 MeSH Terms
Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody.
Kong R, Xu K, Zhou T, Acharya P, Lemmin T, Liu K, Ozorowski G, Soto C, Taft JD, Bailer RT, Cale EM, Chen L, Choi CW, Chuang GY, Doria-Rose NA, Druz A, Georgiev IS, Gorman J, Huang J, Joyce MG, Louder MK, Ma X, McKee K, O'Dell S, Pancera M, Yang Y, Blanchard SC, Mothes W, Burton DR, Koff WC, Connors M, Ward AB, Kwong PD, Mascola JR
(2016) Science 352: 828-33
MeSH Terms: AIDS Vaccines, Amino Acid Sequence, Antibodies, Neutralizing, Antibodies, Viral, B-Lymphocytes, Crystallography, X-Ray, HIV Envelope Protein gp120, HIV Envelope Protein gp41, HIV-1, Humans, Hydrophobic and Hydrophilic Interactions, Immunodominant Epitopes, Molecular Sequence Data, Peptides, Protein Conformation, Viral Fusion Proteins, Virus Internalization
Added May 3, 2017
0 Communities
1 Members
0 Resources
17 MeSH Terms
Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies.
Bornholdt ZA, Ndungo E, Fusco ML, Bale S, Flyak AI, Crowe JE, Chandran K, Saphire EO
(2016) mBio 7: e02154-15
MeSH Terms: Antibodies, Neutralizing, Antibodies, Viral, Carrier Proteins, Cell Line, Crystallography, X-Ray, Ebolavirus, Hemorrhagic Fever, Ebola, Humans, Hydrophobic and Hydrophilic Interactions, Intracellular Signaling Peptides and Proteins, Membrane Glycoproteins, Mutagenesis, Mutation, Niemann-Pick C1 Protein, Protein Binding, Receptors, Virus, Viral Envelope Proteins, Virus Internalization
Added May 4, 2016
0 Communities
1 Members
0 Resources
18 MeSH Terms
Human Metapneumovirus Is Capable of Entering Cells by Fusion with Endosomal Membranes.
Cox RG, Mainou BA, Johnson M, Hastings AK, Schuster JE, Dermody TS, Williams JV
(2015) PLoS Pathog 11: e1005303
MeSH Terms: Bronchi, Cell Line, Endosomes, Flow Cytometry, Humans, Metapneumovirus, Microscopy, Confocal, Paramyxoviridae Infections, RNA, Small Interfering, Respiratory Mucosa, Transfection, Viral Fusion Proteins, Virus Internalization
Added February 4, 2016
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1 Members
0 Resources
13 MeSH Terms
Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress.
Fox JM, Long F, Edeling MA, Lin H, van Duijl-Richter MKS, Fong RH, Kahle KM, Smit JM, Jin J, Simmons G, Doranz BJ, Crowe JE, Fremont DH, Rossmann MG, Diamond MS
(2015) Cell 163: 1095-1107
MeSH Terms: Alphavirus, Alphavirus Infections, Amino Acid Sequence, Animals, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Chikungunya virus, Cryoelectron Microscopy, Epitopes, Glycoproteins, Humans, Immunoglobulin Fab Fragments, Mice, Models, Molecular, Molecular Sequence Data, Protein Structure, Tertiary, Sequence Alignment, Viral Envelope Proteins, Viral Vaccines, Virus Internalization
Added January 26, 2016
0 Communities
1 Members
0 Resources
21 MeSH Terms
Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus.
Smith SA, Silva LA, Fox JM, Flyak AI, Kose N, Sapparapu G, Khomandiak S, Khomadiak S, Ashbrook AW, Kahle KM, Fong RH, Swayne S, Doranz BJ, McGee CE, Heise MT, Pal P, Brien JD, Austin SK, Diamond MS, Dermody TS, Crowe JE
(2015) Cell Host Microbe 18: 86-95
MeSH Terms: Animals, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Chemoprevention, Chikungunya Fever, Chikungunya virus, Disease Models, Animal, Humans, Immunization, Passive, Inhibitory Concentration 50, Mice, Protein Binding, Survival Analysis, Treatment Outcome, Viral Envelope Proteins, Virus Internalization
Added January 26, 2016
0 Communities
2 Members
0 Resources
17 MeSH Terms
Serotonin Receptor Agonist 5-Nonyloxytryptamine Alters the Kinetics of Reovirus Cell Entry.
Mainou BA, Ashbrook AW, Smith EC, Dorset DC, Denison MR, Dermody TS
(2015) J Virol 89: 8701-12
MeSH Terms: Animals, Antiviral Agents, Biological Transport, Cell Line, Cell Survival, Chikungunya virus, Chlorocebus aethiops, Cholera Toxin, Cricetinae, Cytoskeleton, Endosomes, HeLa Cells, Humans, Interferon-gamma, L Cells, Methiothepin, Mice, Murine hepatitis virus, Reoviridae, Reoviridae Infections, Serotonin Antagonists, Transferrin, Tryptamines, Vero Cells, Virus Assembly, Virus Attachment, Virus Internalization
Added February 4, 2016
0 Communities
1 Members
0 Resources
27 MeSH Terms
HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear Entry.
Zhou J, Price AJ, Halambage UD, James LC, Aiken C
(2015) J Virol 89: 9068-79
MeSH Terms: Amino Acid Substitution, Anti-HIV Agents, Binding Sites, CD4-Positive T-Lymphocytes, Capsid, Capsid Proteins, Cell Line, Drug Resistance, Viral, HIV Infections, HIV-1, Host-Pathogen Interactions, Humans, Indoles, Macrophages, Molecular Chaperones, Nuclear Pore Complex Proteins, Phenylalanine, Protein Binding, Protein Conformation, RNA Interference, RNA, Small Interfering, Virus Internalization, Virus Replication, beta Karyopherins, mRNA Cleavage and Polyadenylation Factors
Added February 4, 2016
0 Communities
1 Members
0 Resources
25 MeSH Terms
Identification of residues in the human respiratory syncytial virus fusion protein that modulate fusion activity and pathogenesis.
Hotard AL, Lee S, Currier MG, Crowe JE, Sakamoto K, Newcomb DC, Peebles RS, Plemper RK, Moore ML
(2015) J Virol 89: 512-22
MeSH Terms: Animals, Cell Line, DNA Mutational Analysis, Disease Models, Animal, Female, Histocytochemistry, Humans, Lung, Mice, Inbred BALB C, Respiratory Syncytial Virus Infections, Respiratory Syncytial Virus, Human, Viral Fusion Proteins, Viral Load, Virus Internalization, Weight Loss
Added January 20, 2015
0 Communities
2 Members
0 Resources
15 MeSH Terms