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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 48

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Human cytochrome P450 enzymes bind drugs and other substrates mainly through conformational-selection modes.
Guengerich FP, Wilkey CJ, Phan TTN
(2019) J Biol Chem 294: 10928-10941
MeSH Terms: Catalysis, Cytochrome P-450 CYP2D6, Cytochrome P-450 CYP2E1, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Humans, Kinetics, Lauric Acids, Ligands, Molecular Conformation, Oxidation-Reduction, Palmitic Acid, Protein Binding, Protein Conformation, Spiro Compounds, Substrate Specificity
Added March 3, 2020
0 Communities
1 Members
0 Resources
17 MeSH Terms
Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol.
Brackman DJ, Yee SW, Enogieru OJ, Shaffer C, Ranatunga D, Denny JC, Wei WQ, Kamatani Y, Kubo M, Roden DM, Jorgenson E, Giacomini KM
(2019) Clin Pharmacol Ther 106: 623-631
MeSH Terms: ATP Binding Cassette Transporter, Subfamily G, Member 2, Aged, Aged, 80 and over, Allopurinol, Cytokines, Ethnic Groups, Female, Genome-Wide Association Study, Glucose Transport Proteins, Facilitative, Humans, Male, Middle Aged, Neoplasm Proteins, Oxypurinol, Prognosis, Uric Acid
Added March 24, 2020
0 Communities
1 Members
0 Resources
16 MeSH Terms
Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levels.
Tin A, Li Y, Brody JA, Nutile T, Chu AY, Huffman JE, Yang Q, Chen MH, Robinson-Cohen C, Macé A, Liu J, Demirkan A, Sorice R, Sedaghat S, Swen M, Yu B, Ghasemi S, Teumer A, Vollenweider P, Ciullo M, Li M, Uitterlinden AG, Kraaij R, Amin N, van Rooij J, Kutalik Z, Dehghan A, McKnight B, van Duijn CM, Morrison A, Psaty BM, Boerwinkle E, Fox CS, Woodward OM, Köttgen A
(2018) Nat Commun 9: 4228
MeSH Terms: Exome, Genetic Predisposition to Disease, Glucose Transport Proteins, Facilitative, Humans, Kidney Function Tests, Meta-Analysis as Topic, Organic Anion Transporters, Organic Cation Transport Proteins, Protein Structure, Secondary, Uric Acid
Added January 3, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
MR-PheWAS: exploring the causal effect of SUA level on multiple disease outcomes by using genetic instruments in UK Biobank.
Li X, Meng X, Spiliopoulou A, Timofeeva M, Wei WQ, Gifford A, Shen X, He Y, Varley T, McKeigue P, Tzoulaki I, Wright AF, Joshi P, Denny JC, Campbell H, Theodoratou E
(2018) Ann Rheum Dis 77: 1039-1047
MeSH Terms: Adult, Arthritis, Autoimmune Diseases, Biological Specimen Banks, Celiac Disease, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Gout, Humans, Hypertension, Male, Mendelian Randomization Analysis, Middle Aged, Multimorbidity, Myocardial Infarction, Prognosis, Risk Assessment, United Kingdom, Uric Acid
Added March 14, 2018
0 Communities
1 Members
0 Resources
20 MeSH Terms
"Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates.
Mortenson DE, Brighty GJ, Plate L, Bare G, Chen W, Li S, Wang H, Cravatt BF, Forli S, Powers ET, Sharpless KB, Wilson IA, Kelly JW
(2018) J Am Chem Soc 140: 200-210
MeSH Terms: Drug Discovery, HEK293 Cells, Humans, Ligands, Models, Molecular, Molecular Structure, Proteins, Sulfuric Acid Esters
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Epoxygenated Fatty Acids Inhibit Retinal Vascular Inflammation.
Capozzi ME, Hammer SS, McCollum GW, Penn JS
(2016) Sci Rep 6: 39211
MeSH Terms: 8,11,14-Eicosatrienoic Acid, Adamantane, Animals, Cells, Cultured, Disease Models, Animal, Down-Regulation, Endothelial Cells, Epoxy Compounds, Fatty Acids, Unsaturated, Humans, Intercellular Adhesion Molecule-1, Lauric Acids, Male, Mice, Retinal Vasculitis, Retinal Vessels, Tumor Necrosis Factor-alpha, Vascular Cell Adhesion Molecule-1
Added April 10, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue.
Chen W, Dong J, Plate L, Mortenson DE, Brighty GJ, Li S, Liu Y, Galmozzi A, Lee PS, Hulce JJ, Cravatt BF, Saez E, Powers ET, Wilson IA, Sharpless KB, Kelly JW
(2016) J Am Chem Soc 138: 7353-64
MeSH Terms: Binding Sites, Cell Culture Techniques, Crystallography, X-Ray, Fatty Acid-Binding Proteins, Fluorine, HeLa Cells, Humans, Hydrophobic and Hydrophilic Interactions, Ligands, MCF-7 Cells, Receptors, Retinoic Acid, Sulfuric Acids, Tyrosine
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Serum Urate and Incident Cardiovascular Disease: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.
Wang H, Jacobs DR, Gaffo AL, Gross MD, Goff DC, Carr JJ
(2015) PLoS One 10: e0138067
MeSH Terms: Adolescent, Adult, Biomarkers, Cardiovascular Diseases, Cohort Studies, Coronary Artery Disease, Coronary Vessels, Female, Humans, Incidence, Male, Risk Factors, Uric Acid, Young Adult
Added September 29, 2016
0 Communities
1 Members
0 Resources
14 MeSH Terms
Uric acid correlates to oxidation and inflammation in opposite directions in women.
Wu SH, Shu XO, Milne G, Xiang YB, Zhang X, Cai Q, Fazio S, Linton MF, Chen H, Purdue M, Rothman N, Gao YT, Zheng W, Yang G
(2015) Biomarkers 20: 225-31
MeSH Terms: Aged, Biomarkers, C-Reactive Protein, Case-Control Studies, Chromatography, Liquid, F2-Isoprostanes, Female, Gas Chromatography-Mass Spectrometry, Humans, Inflammation, Inflammation Mediators, Interleukin-6, Middle Aged, Oxidation-Reduction, Tandem Mass Spectrometry, Tumor Necrosis Factor-alpha, Uric Acid
Added March 10, 2016
1 Communities
3 Members
0 Resources
17 MeSH Terms
Even free radicals should follow some rules: a guide to free radical research terminology and methodology.
Forman HJ, Augusto O, Brigelius-Flohe R, Dennery PA, Kalyanaraman B, Ischiropoulos H, Mann GE, Radi R, Roberts LJ, Vina J, Davies KJ
(2015) Free Radic Biol Med 78: 233-5
MeSH Terms: Animals, Antioxidants, Fluorescent Dyes, Free Radical Scavengers, Free Radicals, Humans, Lipid Peroxidation, Reactive Nitrogen Species, Reactive Oxygen Species, Terminology as Topic, Thiobarbituric Acid Reactive Substances
Added February 15, 2016
0 Communities
1 Members
0 Resources
11 MeSH Terms