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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 15

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Biochemical and Proteomic Analysis of Ubiquitination of Hsc70 and Hsp70 by the E3 Ligase CHIP.
Soss SE, Rose KL, Hill S, Jouan S, Chazin WJ
(2015) PLoS One 10: e0128240
MeSH Terms: HSC70 Heat-Shock Proteins, Humans, Proteomics, Recombinant Proteins, Ubiquitin, Ubiquitin-Conjugating Enzymes, Ubiquitin-Protein Ligases, Ubiquitination
Added February 5, 2016
0 Communities
1 Members
0 Resources
8 MeSH Terms
Activation of UbcH5c~Ub is the result of a shift in interdomain motions of the conjugate bound to U-box E3 ligase E4B.
Soss SE, Klevit RE, Chazin WJ
(2013) Biochemistry 52: 2991-9
MeSH Terms: Biocatalysis, Models, Molecular, Nuclear Magnetic Resonance, Biomolecular, Protein Binding, Ubiquitin-Conjugating Enzymes, Ubiquitin-Protein Ligases
Added March 7, 2014
0 Communities
1 Members
0 Resources
6 MeSH Terms
Structure of an E3:E2~Ub complex reveals an allosteric mechanism shared among RING/U-box ligases.
Pruneda JN, Littlefield PJ, Soss SE, Nordquist KA, Chazin WJ, Brzovic PS, Klevit RE
(2012) Mol Cell 47: 933-42
MeSH Terms: Crystallography, X-Ray, Hydrogen Bonding, Protein Binding, Protein Conformation, Protein Subunits, Signal Transduction, Ubiquitin, Ubiquitin-Conjugating Enzymes, Ubiquitin-Protein Ligases
Added March 12, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
E2 conjugating enzyme selectivity and requirements for function of the E3 ubiquitin ligase CHIP.
Soss SE, Yue Y, Dhe-Paganon S, Chazin WJ
(2011) J Biol Chem 286: 21277-86
MeSH Terms: Cytosol, DNA, Escherichia coli, Magnetic Resonance Spectroscopy, Molecular Conformation, Mutagenesis, Site-Directed, Protein Conformation, Protein Denaturation, Protein Folding, Protein Interaction Mapping, Recombinant Proteins, Triticum, Ubiquitin, Ubiquitin-Conjugating Enzymes, Ubiquitin-Protein Ligases
Added March 7, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
SLUG-induced elevation of D1 cyclin in breast cancer cells through the inhibition of its ubiquitination.
Mittal MK, Singh K, Misra S, Chaudhuri G
(2011) J Biol Chem 286: 469-79
MeSH Terms: Breast Neoplasms, Cell Line, Tumor, Cell Proliferation, Chromatin Assembly and Disassembly, Cyclin D1, Drug Resistance, Neoplasm, Gene Expression Regulation, Neoplastic, Gene Knockdown Techniques, Humans, Neoplasm Invasiveness, Promoter Regions, Genetic, Proteasome Endopeptidase Complex, Snail Family Transcription Factors, Tamoxifen, Transcription Factors, Ubiquitin-Conjugating Enzymes, Ubiquitination
Added July 10, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
Engineering a ubiquitin ligase reveals conformational flexibility required for ubiquitin transfer.
Qian SB, Waldron L, Choudhary N, Klevit RE, Chazin WJ, Patterson C
(2009) J Biol Chem 284: 26797-802
MeSH Terms: Binding Sites, Catalysis, Crystallization, Crystallography, X-Ray, Humans, Models, Molecular, Mutation, Protein Conformation, Protein Engineering, Protein Multimerization, Protein Structure, Tertiary, Substrate Specificity, Ubiquitin, Ubiquitin-Conjugating Enzymes, Ubiquitin-Protein Ligases, Ubiquitination
Added March 12, 2014
0 Communities
1 Members
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16 MeSH Terms
no poles encodes a predicted E3 ubiquitin ligase required for early embryonic development of Drosophila.
Merkle JA, Rickmyre JL, Garg A, Loggins EB, Jodoin JN, Lee E, Wu LP, Lee LA
(2009) Development 136: 449-59
MeSH Terms: Amino Acid Sequence, Animals, Checkpoint Kinase 2, DNA Damage, Drosophila, Drosophila Proteins, Embryo, Nonmammalian, Female, HeLa Cells, Humans, Mitosis, Molecular Sequence Data, Mutation, Protein Binding, Protein Serine-Threonine Kinases, Spindle Apparatus, Two-Hybrid System Techniques, Ubiquitin-Conjugating Enzymes, Ubiquitin-Protein Ligases
Added March 5, 2014
0 Communities
2 Members
0 Resources
19 MeSH Terms
Polyubiquitylation of histone H2B.
Geng F, Tansey WP
(2008) Mol Biol Cell 19: 3616-24
MeSH Terms: Catalysis, Chromatin, DNA Methylation, Gene Expression Regulation, Fungal, Histones, Lysine, Models, Biological, Plasmids, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Transcription, Genetic, Ubiquitin, Ubiquitin-Conjugating Enzymes
Added March 10, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity.
Huang DT, Hunt HW, Zhuang M, Ohi MD, Holton JM, Schulman BA
(2007) Nature 445: 394-8
MeSH Terms: Adenosine Triphosphate, Binding Sites, Crystallography, X-Ray, Esters, Humans, Models, Molecular, NEDD8 Protein, Protein Conformation, Structure-Activity Relationship, Sulfhydryl Compounds, Ubiquitin-Activating Enzymes, Ubiquitin-Conjugating Enzymes, Ubiquitins
Added March 5, 2014
0 Communities
2 Members
0 Resources
13 MeSH Terms
SCFCdc4-mediated degradation of the Hac1p transcription factor regulates the unfolded protein response in Saccharomyces cerevisiae.
Pal B, Chan NC, Helfenbaum L, Tan K, Tansey WP, Gething MJ
(2007) Mol Biol Cell 18: 426-40
MeSH Terms: Amino Acid Motifs, Amino Acid Sequence, Anaphase-Promoting Complex-Cyclosome, Basic-Leucine Zipper Transcription Factors, Binding Sites, Cell Cycle Proteins, Cell Nucleus, Cell Survival, Cyclin-Dependent Kinase 8, Cyclin-Dependent Kinases, F-Box Proteins, Mitogen-Activated Protein Kinase Kinases, Molecular Sequence Data, Mutation, Proteasome Endopeptidase Complex, Protein Folding, Repressor Proteins, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Serine, Transcription Factors, Two-Hybrid System Techniques, Ubiquitin, Ubiquitin-Conjugating Enzymes, Ubiquitin-Protein Ligase Complexes, Ubiquitin-Protein Ligases
Added March 10, 2014
0 Communities
1 Members
0 Resources
26 MeSH Terms