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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 14

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Heterozygous loss of TSC2 alters p53 signaling and human stem cell reprogramming.
Armstrong LC, Westlake G, Snow JP, Cawthon B, Armour E, Bowman AB, Ess KC
(2017) Hum Mol Genet 26: 4629-4641
MeSH Terms: Adolescent, Adult, Alleles, Cellular Reprogramming, Child, Child, Preschool, Female, Fibroblasts, Genes, p53, Heterozygote, Humans, Induced Pluripotent Stem Cells, Infant, Loss of Heterozygosity, Male, Mutation, RNA, Small Interfering, Signal Transduction, TOR Serine-Threonine Kinases, Tuberous Sclerosis, Tuberous Sclerosis Complex 1 Protein, Tuberous Sclerosis Complex 2 Protein, Tumor Suppressor Protein p53, Tumor Suppressor Proteins
Added April 11, 2018
0 Communities
1 Members
0 Resources
24 MeSH Terms
miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in gastric cancer through regulation of the PI3K/AKT/mTOR pathway.
Riquelme I, Tapia O, Leal P, Sandoval A, Varga MG, Letelier P, Buchegger K, Bizama C, Espinoza JA, Peek RM, Araya JC, Roa JC
(2016) Cell Oncol (Dordr) 39: 23-33
MeSH Terms: Base Sequence, Cell Death, Cell Line, Tumor, Cell Movement, Cell Proliferation, Cell Survival, Class I Phosphatidylinositol 3-Kinases, Down-Regulation, Gene Expression Regulation, Neoplastic, Genes, Tumor Suppressor, Humans, MicroRNAs, Models, Biological, Molecular Sequence Data, Neoplasm Invasiveness, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, Signal Transduction, Stomach Neoplasms, TOR Serine-Threonine Kinases, Transfection, Tuberous Sclerosis Complex 1 Protein, Tumor Stem Cell Assay, Tumor Suppressor Proteins
Added February 5, 2016
0 Communities
1 Members
0 Resources
24 MeSH Terms
Conditional and domain-specific inactivation of the Tsc2 gene in neural progenitor cells.
Fu C, Ess KC
(2013) Genesis 51: 284-92
MeSH Terms: Alleles, Animals, Brain, Exons, Founder Effect, Gene Deletion, Gene Knock-In Techniques, Homozygote, Mice, Mice, Transgenic, Neural Stem Cells, Protein Structure, Tertiary, TOR Serine-Threonine Kinases, Tuberous Sclerosis Complex 1 Protein, Tumor Suppressor Proteins
Added December 2, 2013
2 Communities
1 Members
0 Resources
15 MeSH Terms
Cystogenesis and elongated primary cilia in Tsc1-deficient distal convoluted tubules.
Armour EA, Carson RP, Ess KC
(2012) Am J Physiol Renal Physiol 303: F584-92
MeSH Terms: Aging, Animals, Carrier Proteins, Cilia, DNA, Gene Expression Regulation, Kidney Diseases, Kidney Tubules, Distal, Mechanistic Target of Rapamycin Complex 1, Mice, Mice, Knockout, Multiprotein Complexes, Proteins, Rapamycin-Insensitive Companion of mTOR Protein, Signal Transduction, TOR Serine-Threonine Kinases, Trans-Activators, Transcription Factors, Tuberous Sclerosis Complex 1 Protein, Tumor Suppressor Proteins
Added August 25, 2013
1 Communities
1 Members
0 Resources
20 MeSH Terms
MicroRNAs/TP53 feedback circuitry in glioblastoma multiforme.
Suh SS, Yoo JY, Nuovo GJ, Jeon YJ, Kim S, Lee TJ, Kim T, Bakàcs A, Alder H, Kaur B, Aqeilan RI, Pichiorri F, Croce CM
(2012) Proc Natl Acad Sci U S A 109: 5316-21
MeSH Terms: Brain Neoplasms, Cell Cycle, Cell Proliferation, E2F1 Transcription Factor, Glioblastoma, Humans, MicroRNAs, Proto-Oncogene Proteins c-mdm2, Proto-Oncogene Proteins c-myc, Transcription, Genetic, Tuberous Sclerosis Complex 1 Protein, Tumor Suppressor Protein p53, Tumor Suppressor Proteins
Added December 22, 2013
0 Communities
1 Members
0 Resources
13 MeSH Terms
GABAergic interneuron development and function is modulated by the Tsc1 gene.
Fu C, Cawthon B, Clinkscales W, Bruce A, Winzenburger P, Ess KC
(2012) Cereb Cortex 22: 2111-9
MeSH Terms: Animals, Brain, Flow Cytometry, Immunohistochemistry, Interneurons, Mice, Mice, Knockout, Neurogenesis, Polymerase Chain Reaction, Tuberous Sclerosis Complex 1 Protein, Tumor Suppressor Proteins, gamma-Aminobutyric Acid
Added October 30, 2012
0 Communities
1 Members
0 Resources
12 MeSH Terms
Neuronal and glia abnormalities in Tsc1-deficient forebrain and partial rescue by rapamycin.
Carson RP, Van Nielen DL, Winzenburger PA, Ess KC
(2012) Neurobiol Dis 45: 369-80
MeSH Terms: Animals, Brain, Cell Death, Disease Models, Animal, Mice, Mice, Knockout, Neuroglia, Neurons, Signal Transduction, Sirolimus, Transcription Factors, Tuberous Sclerosis, Tuberous Sclerosis Complex 1 Protein, Tumor Suppressor Proteins
Added October 30, 2012
0 Communities
1 Members
0 Resources
14 MeSH Terms
A 'Tsc, Tsc' keeps the kids quie(scen)t and holds down ROS.
Boothby M, Lee K
(2011) Nat Immunol 12: 811-2
MeSH Terms: Adaptive Immunity, Animals, CD4-Positive T-Lymphocytes, Mechanistic Target of Rapamycin Complex 1, Multiprotein Complexes, Proteins, Signal Transduction, TOR Serine-Threonine Kinases, Trans-Activators, Transcription Factors, Tuberous Sclerosis Complex 1 Protein, Tumor Suppressor Proteins
Added February 15, 2016
0 Communities
1 Members
0 Resources
12 MeSH Terms
An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice.
Traykova-Brauch M, Schönig K, Greiner O, Miloud T, Jauch A, Bode M, Felsher DW, Glick AB, Kwiatkowski DJ, Bujard H, Horst J, von Knebel Doeberitz M, Niggli FK, Kriz W, Gröne HJ, Koesters R
(2008) Nat Med 14: 979-84
MeSH Terms: Animals, Disease Models, Animal, Doxycycline, Fibrosis, Immunohistochemistry, Kidney Tubules, Mice, Mice, Transgenic, PAX8 Transcription Factor, Paired Box Transcription Factors, Polycystic Kidney Diseases, Promoter Regions, Genetic, Trans-Activators, Transforming Growth Factor beta1, Tuberous Sclerosis Complex 1 Protein, Tumor Suppressor Proteins
Added September 9, 2013
0 Communities
0 Members
1 Resources
16 MeSH Terms
Phospholipase D1 is an effector of Rheb in the mTOR pathway.
Sun Y, Fang Y, Yoon MS, Zhang C, Roccio M, Zwartkruis FJ, Armstrong M, Brown HA, Chen J
(2008) Proc Natl Acad Sci U S A 105: 8286-91
MeSH Terms: Cell Line, Humans, Monomeric GTP-Binding Proteins, Neuropeptides, Phospholipase D, Protein Kinases, RNA Interference, RNA, Small Nuclear, Ras Homolog Enriched in Brain Protein, Signal Transduction, TOR Serine-Threonine Kinases, Tuberous Sclerosis Complex 1 Protein, Tuberous Sclerosis Complex 2 Protein, Tumor Suppressor Proteins
Added March 21, 2013
0 Communities
2 Members
0 Resources
14 MeSH Terms