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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 7 of 7

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Cytochromes P450 catalyze the reduction of α,β-unsaturated aldehydes.
Amunom I, Dieter LJ, Tamasi V, Cai J, Conklin DJ, Srivastava S, Martin MV, Guengerich FP, Prough RA
(2011) Chem Res Toxicol 24: 1223-30
MeSH Terms: Aldehydes, Animals, Anthracenes, Biocatalysis, Cells, Cultured, Cyanamide, Cytochrome P-450 CYP3A, Hepatocytes, Humans, Hydroxy Acids, Male, Mice, Microsomes, Liver, NADP, Oxidation-Reduction, Oxygen, Rats, Rats, Sprague-Dawley, Recombinant Proteins, Troleandomycin
Added March 26, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Oral erythromycin and the risk of sudden death from cardiac causes.
Ray WA, Murray KT, Meredith S, Narasimhulu SS, Hall K, Stein CM
(2004) N Engl J Med 351: 1089-96
MeSH Terms: Administration, Oral, Adult, Aged, Amoxicillin, Anti-Bacterial Agents, Aryl Hydrocarbon Hydroxylases, Calcium Channel Blockers, Confounding Factors, Epidemiologic, Cytochrome P-450 CYP3A, Death, Sudden, Cardiac, Diltiazem, Drug Interactions, Erythromycin, Female, Humans, Male, Middle Aged, Multivariate Analysis, Nitroimidazoles, Oxidoreductases, N-Demethylating, Risk, Troleandomycin, Verapamil
Added December 10, 2013
0 Communities
3 Members
0 Resources
23 MeSH Terms
Different in vitro metabolism of paclitaxel and docetaxel in humans, rats, pigs, and minipigs.
Vaclavikova R, Soucek P, Svobodova L, Anzenbacher P, Simek P, Guengerich FP, Gut I
(2004) Drug Metab Dispos 32: 666-74
MeSH Terms: Adolescent, Adult, Animals, Antineoplastic Agents, Phytogenic, Cytochrome P-450 Enzyme System, Docetaxel, Enzyme Inhibitors, Flavonoids, Flavonols, Humans, In Vitro Techniques, Isoenzymes, Kinetics, Male, Microsomes, Liver, Paclitaxel, Rats, Rats, Wistar, Species Specificity, Swine, Swine, Miniature, Taxoids, Troleandomycin
Added May 26, 2014
0 Communities
1 Members
0 Resources
23 MeSH Terms
Identification of human liver cytochrome P-450 3A4 as the enzyme responsible for fentanyl and sufentanil N-dealkylation.
Tateishi T, Krivoruk Y, Ueng YF, Wood AJ, Guengerich FP, Wood M
(1996) Anesth Analg 82: 167-72
MeSH Terms: Analgesics, Opioid, Animals, Antibodies, Antibody Specificity, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Dealkylation, Enzyme Inhibitors, Erythromycin, Fentanyl, Humans, Kinetics, Liver, Microsomes, Liver, Mixed Function Oxygenases, Norpregnenes, Rabbits, Sufentanil, Troleandomycin
Added March 5, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Oxidation of 17 alpha-ethynylestradiol by human liver cytochrome P-450.
Guengerich FP
(1988) Mol Pharmacol 33: 500-8
MeSH Terms: Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Ethinyl Estradiol, Humans, Immunologic Techniques, In Vitro Techniques, Microsomes, Liver, Nifedipine, Oxidation-Reduction, Substrate Specificity, Troleandomycin
Added March 5, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver.
Shimada T, Guengerich FP
(1989) Proc Natl Acad Sci U S A 86: 462-5
MeSH Terms: Aflatoxin B1, Aflatoxins, Antibodies, Benzoflavones, Biotransformation, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme System, Humans, Immunochemistry, Microsomes, Liver, Mixed Function Oxygenases, Nifedipine, Oxidation-Reduction, Sterigmatocystin, Troleandomycin
Added March 5, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Human liver microsomal N-hydroxylation of dapsone by cytochrome P-4503A4.
Fleming CM, Branch RA, Wilkinson GR, Guengerich FP
(1992) Mol Pharmacol 41: 975-80
MeSH Terms: Antibodies, Benzoflavones, Cytochrome P-450 Enzyme System, Humans, Hydroxylation, Isoenzymes, Kinetics, Microsomes, Liver, Norpregnenes, Troleandomycin
Added March 5, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms