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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 11

Publication Record

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The best-laid plans.
Harris RC
(2013) Am J Physiol Renal Physiol 304: F1086-7
MeSH Terms: Animals, Diabetic Nephropathies, Kidney, Male, Oleanolic Acid, Triterpenes
Added January 28, 2014
2 Communities
1 Members
0 Resources
6 MeSH Terms
Co-treatment with ginsenoside Rh2 and betulinic acid synergistically induces apoptosis in human cancer cells in association with enhanced capsase-8 activation, bax translocation, and cytochrome c release.
Li Q, Li Y, Wang X, Fang X, He K, Guo X, Zhan Z, Sun C, Jin YH
(2011) Mol Carcinog 50: 760-9
MeSH Terms: Antineoplastic Agents, Phytogenic, Apoptosis, BH3 Interacting Domain Death Agonist Protein, Blotting, Western, Caspase 3, Caspase 8, Caspase 9, Cell Line, Tumor, Cell Survival, Cytochromes c, Dose-Response Relationship, Drug, Drug Synergism, Enzyme Activation, Flow Cytometry, Ginsenosides, HeLa Cells, Hep G2 Cells, Humans, Molecular Structure, Neoplasms, Pentacyclic Triterpenes, Poly(ADP-ribose) Polymerases, Protein Transport, RNA Interference, Triterpenes, bcl-2-Associated X Protein
Added July 28, 2015
0 Communities
1 Members
0 Resources
26 MeSH Terms
Compelling computational evidence for the concerted cyclization of the ABC rings of hopene from protonated squalene.
Smentek L, Hess BA
(2010) J Am Chem Soc 132: 17111-7
MeSH Terms: Cyclization, Models, Molecular, Molecular Conformation, Protons, Quantum Theory, Squalene, Triterpenes
Added February 15, 2016
0 Communities
1 Members
0 Resources
7 MeSH Terms
Betulin induces mitochondrial cytochrome c release associated apoptosis in human cancer cells.
Li Y, He K, Huang Y, Zheng D, Gao C, Cui L, Jin YH
(2010) Mol Carcinog 49: 630-40
MeSH Terms: Antineoplastic Agents, Phytogenic, Apoptosis, Apoptosis Regulatory Proteins, Caspase 3, Caspase 7, Caspase 9, Cell Line, Tumor, Cell Survival, Cytochromes c, HeLa Cells, Hep G2 Cells, Humans, Intracellular Signaling Peptides and Proteins, K562 Cells, Mitochondria, Mitochondrial Proteins, Neoplasms, Triterpenes, bcl-2 Homologous Antagonist-Killer Protein, bcl-2-Associated X Protein
Added July 28, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms
Human immunodeficiency virus type 1 resistance to the small molecule maturation inhibitor 3-O-(3',3'-dimethylsuccinyl)-betulinic acid is conferred by a variety of single amino acid substitutions at the CA-SP1 cleavage site in Gag.
Zhou J, Chen CH, Aiken C
(2006) J Virol 80: 12095-101
MeSH Terms: Amino Acid Substitution, Anti-HIV Agents, Cell Line, Tumor, Drug Resistance, Viral, Gene Products, gag, HIV-1, Humans, Mutagenesis, Succinates, Triterpenes, Virus Assembly, Virus Replication
Added February 19, 2015
0 Communities
1 Members
0 Resources
12 MeSH Terms
Betulinic acid derivatives as HIV-1 antivirals.
Aiken C, Chen CH
(2005) Trends Mol Med 11: 31-6
MeSH Terms: Anti-HIV Agents, HIV-1, Humans, Pentacyclic Triterpenes, Triterpenes, Virus Replication
Added February 19, 2015
0 Communities
1 Members
0 Resources
6 MeSH Terms
The sequence of the CA-SP1 junction accounts for the differential sensitivity of HIV-1 and SIV to the small molecule maturation inhibitor 3-O-{3',3'-dimethylsuccinyl}-betulinic acid.
Zhou J, Chen CH, Aiken C
(2004) Retrovirology 1: 15
MeSH Terms: Animals, Anti-HIV Agents, Base Sequence, CD4-Positive T-Lymphocytes, Cell Line, DNA Primers, Drug Resistance, Viral, HIV-1, Humans, Kidney, Pregnancy-Specific beta 1-Glycoproteins, Simian Immunodeficiency Virus, Succinates, Triterpenes, Virus Replication
Added February 19, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms
Concerted nature of AB ring formation in the enzymatic cyclization of squalene to hopenes.
Hess BA, Smentek L
(2004) Org Lett 6: 1717-20
MeSH Terms: Crystallography, X-Ray, Cyclization, Intramolecular Transferases, Models, Molecular, Molecular Conformation, Squalene, Triterpenes
Added February 15, 2016
0 Communities
1 Members
0 Resources
7 MeSH Terms
Bifunctional anti-human immunodeficiency virus type 1 small molecules with two novel mechanisms of action.
Huang L, Yuan X, Aiken C, Chen CH
(2004) Antimicrob Agents Chemother 48: 663-5
MeSH Terms: Animals, Anti-HIV Agents, COS Cells, Chlorocebus aethiops, HIV Core Protein p24, HIV Envelope Protein gp120, HIV-1, Pentacyclic Triterpenes, Structure-Activity Relationship, Triterpenes, Virus Replication
Added February 19, 2015
0 Communities
1 Members
0 Resources
11 MeSH Terms
Gene expression changes in the human fibroblast induced by Centella asiatica triterpenoids.
Coldren CD, Hashim P, Ali JM, Oh SK, Sinskey AJ, Rha C
(2003) Planta Med 69: 725-32
MeSH Terms: Cell Line, Centella, Dose-Response Relationship, Drug, Fibroblasts, Gene Expression Regulation, Humans, Pentacyclic Triterpenes, Phytotherapy, RNA, Terpenes, Triterpenes, Wound Healing
Added November 17, 2011
0 Communities
1 Members
0 Resources
12 MeSH Terms