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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 92

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TGF-β and Diabetic Nephropathy: Lessons Learned Over the Past 20 Years.
Gewin LS
(2020) Am J Med Sci 359: 70-72
MeSH Terms: Diabetic Nephropathies, History, 20th Century, History, 21st Century, Humans, Kidney, Transforming Growth Factor beta1
Added March 18, 2020
0 Communities
1 Members
0 Resources
6 MeSH Terms
TGF-β promotes fibrosis after severe acute kidney injury by enhancing renal macrophage infiltration.
Chung S, Overstreet JM, Li Y, Wang Y, Niu A, Wang S, Fan X, Sasaki K, Jin GN, Khodo SN, Gewin L, Zhang MZ, Harris RC
(2018) JCI Insight 3:
MeSH Terms: Acute Kidney Injury, Animals, Bone Marrow Cells, Chemotactic Factors, Fibrosis, Kidney, Macrophages, Male, Mice, Mice, Transgenic, Monocytes, N-Formylmethionine Leucyl-Phenylalanine, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Transforming Growth Factor beta, Transforming Growth Factor beta1
Added December 26, 2018
0 Communities
2 Members
0 Resources
16 MeSH Terms
The altered mechanical phenotype of fetal fibroblasts hinders myofibroblast differentiation.
Jerrell RJ, Leih MJ, Parekh A
(2019) Wound Repair Regen 27: 29-38
MeSH Terms: Adult, Cell Differentiation, Cells, Cultured, Cicatrix, Collagen Type III, Extracellular Matrix, Female, Fetus, Fibroblasts, Gene Expression Regulation, Humans, Male, Myofibroblasts, Phenotype, Pregnancy, Transforming Growth Factor beta1, Wound Healing, Young Adult
Added March 18, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
PD-1 up-regulation on CD4 T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production.
Celada LJ, Kropski JA, Herazo-Maya JD, Luo W, Creecy A, Abad AT, Chioma OS, Lee G, Hassell NE, Shaginurova GI, Wang Y, Johnson JE, Kerrigan A, Mason WR, Baughman RP, Ayers GD, Bernard GR, Culver DA, Montgomery CG, Maher TM, Molyneaux PL, Noth I, Mutsaers SE, Prele CM, Peebles RS, Newcomb DC, Kaminski N, Blackwell TS, Van Kaer L, Drake WP
(2018) Sci Transl Med 10:
MeSH Terms: Adult, Aged, Animals, Bleomycin, CD4-Positive T-Lymphocytes, Cell Proliferation, Collagen Type I, Disease Models, Animal, Female, Fibroblasts, Gene Expression Regulation, Humans, Idiopathic Pulmonary Fibrosis, Interleukin-17, Male, Mice, Middle Aged, Programmed Cell Death 1 Receptor, RNA, Messenger, STAT3 Transcription Factor, Sarcoidosis, Th17 Cells, Transforming Growth Factor beta1, Up-Regulation
Added March 26, 2019
0 Communities
1 Members
0 Resources
24 MeSH Terms
Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer.
Means AL, Freeman TJ, Zhu J, Woodbury LG, Marincola-Smith P, Wu C, Meyer AR, Weaver CJ, Padmanabhan C, An H, Zi J, Wessinger BC, Chaturvedi R, Brown TD, Deane NG, Coffey RJ, Wilson KT, Smith JJ, Sawyers CL, Goldenring JR, Novitskiy SV, Washington MK, Shi C, Beauchamp RD
(2018) Cell Mol Gastroenterol Hepatol 6: 257-276
MeSH Terms: Animals, Bone Morphogenetic Protein 2, Carcinoma, Cell Line, Cell Line, Tumor, Colitis, Colorectal Neoplasms, Dextran Sulfate, Humans, Inflammation, Intestinal Mucosa, Mice, Mice, Inbred C57BL, Mice, Transgenic, Smad4 Protein, Transforming Growth Factor beta1
Added September 12, 2018
1 Communities
1 Members
0 Resources
16 MeSH Terms
Blocking TGF- and -Catenin Epithelial Crosstalk Exacerbates CKD.
Nlandu-Khodo S, Neelisetty S, Phillips M, Manolopoulou M, Bhave G, May L, Clark PE, Yang H, Fogo AB, Harris RC, Taketo MM, Lee E, Gewin LS
(2017) J Am Soc Nephrol 28: 3490-3503
MeSH Terms: Animals, Aristolochic Acids, Cell Nucleus, Collagen, Crosses, Genetic, Epithelium, Female, Gene Deletion, Kidney Failure, Chronic, Kidney Tubules, Proximal, Male, Mice, Mice, Inbred BALB C, Mice, Knockout, Mice, Transgenic, Protein Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Signal Transduction, Transforming Growth Factor beta1, Wnt Proteins, beta Catenin
Added July 18, 2017
0 Communities
4 Members
0 Resources
22 MeSH Terms
Endothelial-to-mesenchymal transition in lipopolysaccharide-induced acute lung injury drives a progenitor cell-like phenotype.
Suzuki T, Tada Y, Nishimura R, Kawasaki T, Sekine A, Urushibara T, Kato F, Kinoshita T, Ikari J, West J, Tatsumi K
(2016) Am J Physiol Lung Cell Mol Physiol 310: L1185-98
MeSH Terms: Acute Lung Injury, Animals, Apoptosis, Cell Proliferation, Cell Transdifferentiation, Cells, Cultured, Endothelial Progenitor Cells, Endothelium, Vascular, Female, Gene Expression, Lipopolysaccharides, Mice, Inbred C57BL, NADPH Oxidases, Phenotype, Reactive Oxygen Species, Transforming Growth Factor beta1, Transforming Growth Factor beta2
Added April 2, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
In-depth genomic data analyses revealed complex transcriptional and epigenetic dysregulations of BRAFV600E in melanoma.
Guo X, Xu Y, Zhao Z
(2015) Mol Cancer 14: 60
MeSH Terms: Cell Transformation, Neoplastic, DNA Methylation, Down-Regulation, Epigenesis, Genetic, Epigenomics, Gene Expression Regulation, Neoplastic, Genomics, Humans, Melanoma, Microphthalmia-Associated Transcription Factor, Proto-Oncogene Proteins B-raf, Skin Neoplasms, Transcription, Genetic, Transcriptome, Transforming Growth Factor beta1, Up-Regulation
Added April 6, 2017
0 Communities
1 Members
0 Resources
16 MeSH Terms
Loss of tumour suppressor PTEN expression in renal injury initiates SMAD3- and p53-dependent fibrotic responses.
Samarakoon R, Helo S, Dobberfuhl AD, Khakoo NS, Falke L, Overstreet JM, Goldschmeding R, Higgins PJ
(2015) J Pathol 236: 421-32
MeSH Terms: Animals, Apoptosis, Aristolochic Acids, Cell Cycle Checkpoints, Cell Line, Cell Proliferation, Disease Models, Animal, Enzyme Inhibitors, Fibrosis, Gene Expression Regulation, Humans, Kidney Diseases, Kidney Tubules, Male, Mice, Inbred C57BL, PTEN Phosphohydrolase, Plasminogen Activator Inhibitor 1, RNA Interference, Signal Transduction, Smad3 Protein, Streptozocin, Transfection, Transforming Growth Factor beta1, Tumor Suppressor Protein p53, Ureteral Obstruction
Added April 19, 2016
0 Communities
1 Members
0 Resources
25 MeSH Terms
EP3 receptor deficiency attenuates pulmonary hypertension through suppression of Rho/TGF-β1 signaling.
Lu A, Zuo C, He Y, Chen G, Piao L, Zhang J, Xiao B, Shen Y, Tang J, Kong D, Alberti S, Chen D, Zuo S, Zhang Q, Yan S, Fei X, Yuan F, Zhou B, Duan S, Yu Y, Lazarus M, Su Y, Breyer RM, Funk CD, Yu Y
(2015) J Clin Invest 125: 1228-42
MeSH Terms: Animals, Cell Hypoxia, Cells, Cultured, Extracellular Matrix, Extracellular Matrix Proteins, Hypertension, Pulmonary, Male, Mice, Inbred C57BL, Mice, Knockout, Pulmonary Artery, Rats, Sprague-Dawley, Receptors, Prostaglandin E, EP3 Subtype, Signal Transduction, Sulfonamides, Transforming Growth Factor beta1, Vascular Remodeling, rho GTP-Binding Proteins, rhoA GTP-Binding Protein
Added February 6, 2016
1 Communities
1 Members
0 Resources
18 MeSH Terms