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MTG16 regulates colonic epithelial differentiation, colitis, and tumorigenesis by repressing E protein transcription factors.
Brown RE, Jacobse J, Anant SA, Blunt KM, Chen B, Vega PN, Jones CT, Pilat JM, Revetta F, Gorby AH, Stengel KR, Choksi YA, Palin K, Piazuelo MB, Washington MK, Lau KS, Goettel JA, Hiebert SW, Short SP, Williams CS
(2022) JCI Insight 7:
MeSH Terms: Animals, Carcinogenesis, Cell Transformation, Neoplastic, Colitis, Dextran Sulfate, Humans, Inflammatory Bowel Diseases, Mice, Mice, Inbred C57BL, Mice, Knockout, Transcription Factors
Added June 13, 2022
1 Communities
0 Members
0 Resources
MeSH Terms
A tRNA processing enzyme is a key regulator of the mitochondrial unfolded protein response.
Held JP, Feng G, Saunders BR, Pereira CV, Burkewitz K, Patel MR
(2022) Elife 11:
MeSH Terms: Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Mitochondria, Transcription Factors, Unfolded Protein Response
Added June 6, 2022
0 Communities
1 Members
0 Resources
MeSH Terms
Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males.
Walker EM, Cha J, Tong X, Guo M, Liu JH, Yu S, Iacovazzo D, Mauvais-Jarvis F, Flanagan SE, Korbonits M, Stafford J, Jacobson DA, Stein R
(2021) Cell Rep 37: 109813
MeSH Terms: Animals, Animals, Genetically Modified, Blood Glucose, Calcium Signaling, Cell Line, Cellular Senescence, DNA Damage, Diabetes Mellitus, Type 2, Disease Models, Animal, Female, Genetic Predisposition to Disease, Humans, Insulin, Insulin-Secreting Cells, Maf Transcription Factors, Large, Male, Mice, Inbred C57BL, Mutation, Missense, Phenotype, Sex Characteristics, Sex Factors
Added November 23, 2021
0 Communities
1 Members
0 Resources
21 MeSH Terms
Insm1, Neurod1, and Pax6 promote murine pancreatic endocrine cell development through overlapping yet distinct RNA transcription and splicing programs.
Dudek KD, Osipovich AB, Cartailler JP, Gu G, Magnuson MA
(2021) G3 (Bethesda) 11:
MeSH Terms: Animals, Basic Helix-Loop-Helix Transcription Factors, Cell Differentiation, Endocrine Cells, Eye Proteins, Gene Expression Regulation, Developmental, Homeodomain Proteins, Mice, PAX6 Transcription Factor, RNA, RNA Splicing, Repressor Proteins, Transcription Factors
Added September 24, 2021
2 Communities
3 Members
0 Resources
13 MeSH Terms
Kidney epithelial targeted mitochondrial transcription factor A deficiency results in progressive mitochondrial depletion associated with severe cystic disease.
Ishii K, Kobayashi H, Taguchi K, Guan N, Li A, Tong C, Davidoff O, Tran PV, Sharma M, Chandel NS, Kapp ME, Fogo AB, Brooks CR, Haase VH
(2021) Kidney Int 99: 657-670
MeSH Terms: Animals, DNA-Binding Proteins, High Mobility Group Proteins, Humans, Kidney, Mice, Mitochondrial Proteins, Transcription Factors
Added November 10, 2020
0 Communities
1 Members
0 Resources
8 MeSH Terms
Succinate Produced by Intestinal Microbes Promotes Specification of Tuft Cells to Suppress Ileal Inflammation.
Banerjee A, Herring CA, Chen B, Kim H, Simmons AJ, Southard-Smith AN, Allaman MM, White JR, Macedonia MC, Mckinley ET, Ramirez-Solano MA, Scoville EA, Liu Q, Wilson KT, Coffey RJ, Washington MK, Goettel JA, Lau KS
(2020) Gastroenterology 159: 2101-2115.e5
MeSH Terms: Animals, Basic Helix-Loop-Helix Transcription Factors, Chemoreceptor Cells, Crohn Disease, DNA, Bacterial, Disease Models, Animal, Feces, Female, Gastrointestinal Microbiome, Humans, Ileitis, Ileum, Intestinal Mucosa, Male, Mice, Mice, Knockout, Protective Factors, RNA, Ribosomal, 16S, RNA-Seq, Single-Cell Analysis, Succinic Acid
Added September 17, 2020
0 Communities
1 Members
0 Resources
21 MeSH Terms
Tuft Cells Inhibit Pancreatic Tumorigenesis in Mice by Producing Prostaglandin D.
DelGiorno KE, Chung CY, Vavinskaya V, Maurer HC, Novak SW, Lytle NK, Ma Z, Giraddi RR, Wang D, Fang L, Naeem RF, Andrade LR, Ali WH, Tseng H, Tsui C, Gubbala VB, Ridinger-Saison M, Ohmoto M, Erikson GA, O'Connor C, Shokhirev MN, Hah N, Urade Y, Matsumoto I, Kaech SM, Singh PK, Manor U, Olive KP, Wahl GM
(2020) Gastroenterology 159: 1866-1881.e8
MeSH Terms: Animals, Carcinoma, Pancreatic Ductal, Cell Transformation, Neoplastic, Ceruletide, Disease Models, Animal, Energy Metabolism, Fibrosis, Humans, Interleukins, Intramolecular Oxidoreductases, Mice, Transgenic, Mutation, Octamer Transcription Factors, Pancreas, Pancreatic Neoplasms, Pancreatitis, Prostaglandin D2, Proto-Oncogene Proteins p21(ras), Time Factors, Transcription Factors
Added March 13, 2021
0 Communities
1 Members
0 Resources
20 MeSH Terms
Myt Transcription Factors Prevent Stress-Response Gene Overactivation to Enable Postnatal Pancreatic β Cell Proliferation, Function, and Survival.
Hu R, Walker E, Huang C, Xu Y, Weng C, Erickson GE, Coldren A, Yang X, Brissova M, Kaverina I, Balamurugan AN, Wright CVE, Li Y, Stein R, Gu G
(2020) Dev Cell 53: 390-405.e10
MeSH Terms: Activating Transcription Factor 4, Animals, Cell Proliferation, DNA-Binding Proteins, Diabetes Mellitus, Female, Heat-Shock Proteins, Humans, Insulin Secretion, Insulin-Secreting Cells, Male, Mice, Mice, Knockout, Stress, Physiological, Transcription Factors
Added May 6, 2020
3 Communities
2 Members
0 Resources
15 MeSH Terms
Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response.
Yang X, Graff SM, Heiser CN, Ho KH, Chen B, Simmons AJ, Southard-Smith AN, David G, Jacobson DA, Kaverina I, Wright CVE, Lau KS, Gu G
(2020) Diabetes 69: 1219-1231
MeSH Terms: Aging, Animals, Basic Helix-Loop-Helix Transcription Factors, Calcium, Cell Survival, Diabetes Mellitus, Female, Gene Expression Regulation, Developmental, Homeostasis, Insulin-Secreting Cells, Male, Mice, Mice, Knockout, Nerve Tissue Proteins, Repressor Proteins, Sin3 Histone Deacetylase and Corepressor Complex
Added April 7, 2020
2 Communities
3 Members
0 Resources
16 MeSH Terms
Gene network transitions in embryos depend upon interactions between a pioneer transcription factor and core histones.
Iwafuchi M, Cuesta I, Donahue G, Takenaka N, Osipovich AB, Magnuson MA, Roder H, Seeholzer SH, Santisteban P, Zaret KS
(2020) Nat Genet 52: 418-427
MeSH Terms: Amino Acid Sequence, Animals, Cell Line, Chromatin, DNA, Female, Gene Expression Regulation, Developmental, Gene Regulatory Networks, Histones, Humans, Mice, Mice, Inbred C57BL, Nucleosomes, Transcription Factors, Transcription, Genetic
Added April 7, 2020
1 Communities
3 Members
0 Resources
15 MeSH Terms