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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 15

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Topoisomerase IIalpha mediates E2F-1-induced chemosensitivity and is a target for p53-mediated transcriptional repression.
Nip J, Hiebert SW
(2000) Cell Biochem Biophys 33: 199-207
MeSH Terms: Antigens, Neoplasm, Apoptosis, Carrier Proteins, Cell Cycle, Cell Cycle Proteins, Cell Line, Cell Survival, DNA Topoisomerases, Type II, DNA-Binding Proteins, E2F Transcription Factors, E2F1 Transcription Factor, Enzyme Inhibitors, Humans, Interleukin-3, Isoenzymes, Piperazines, Retinoblastoma-Binding Protein 1, Sirolimus, Topoisomerase II Inhibitors, Transcription Factor DP1, Transcription Factors, Transcription, Genetic, Tumor Suppressor Protein p53
Added June 10, 2010
1 Communities
1 Members
0 Resources
23 MeSH Terms
E2F-1 induces the stabilization of p53 but blocks p53-mediated transactivation.
Nip J, Strom DK, Eischen CM, Cleveland JL, Zambetti GP, Hiebert SW
(2001) Oncogene 20: 910-20
MeSH Terms: Animals, Binding Sites, Carrier Proteins, Cell Cycle, Cell Cycle Proteins, Cells, Cultured, DNA-Binding Proteins, E2F Transcription Factors, E2F1 Transcription Factor, Mice, Protein Binding, Protein Processing, Post-Translational, Proteins, Retinoblastoma-Binding Protein 1, Transcription Factor DP1, Transcription Factors, Transcriptional Activation, Tumor Suppressor Protein p14ARF, Tumor Suppressor Protein p53
Added June 10, 2010
1 Communities
2 Members
0 Resources
19 MeSH Terms
Oncogenes induce and activate endogenous p73 protein.
Zaika A, Irwin M, Sansome C, Moll UM
(2001) J Biol Chem 276: 11310-6
MeSH Terms: Adenovirus E1A Proteins, Carrier Proteins, Cell Cycle Proteins, DNA-Binding Proteins, E2F Transcription Factors, E2F1 Transcription Factor, Gene Expression Regulation, Neoplastic, Genes, Tumor Suppressor, Genes, myc, Humans, Nuclear Proteins, Oncogenes, Retinoblastoma-Binding Protein 1, Transcription Factor DP1, Transcription Factors, Tumor Cells, Cultured, Tumor Protein p73, Tumor Suppressor Proteins
Added March 5, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
c-myc-enhanced S phase entry in keratinocytes is associated with positive and negative effects on cyclin-dependent kinases.
Alexandrow MG, Moses HL
(1998) J Cell Biochem 70: 528-42
MeSH Terms: Animals, Carrier Proteins, Cell Cycle Proteins, Cells, Cultured, Cyclin-Dependent Kinase Inhibitor p27, Cyclin-Dependent Kinases, DNA-Binding Proteins, E2F Transcription Factors, E2F1 Transcription Factor, Epidermal Growth Factor, G1 Phase, Gene Expression Regulation, Keratinocytes, Mice, Mice, Inbred BALB C, Microtubule-Associated Proteins, Protamine Kinase, Proto-Oncogene Proteins c-myc, Rats, Retinoblastoma-Binding Protein 1, S Phase, Thymidine, Transcription Factor DP1, Transcription Factors, Tumor Suppressor Proteins
Added February 17, 2014
0 Communities
1 Members
0 Resources
25 MeSH Terms
E2F-1 and E2F-3 are functionally distinct in their ability to promote myeloid cell cycle progression and block granulocyte differentiation.
Strom DK, Cleveland JL, Chellappan S, Nip J, Hiebert SW
(1998) Cell Growth Differ 9: 59-69
MeSH Terms: Apoptosis, Carrier Proteins, Cell Cycle, Cell Cycle Proteins, Cell Differentiation, Cell Line, DNA-Binding Proteins, E2F Transcription Factors, E2F1 Transcription Factor, E2F2 Transcription Factor, E2F3 Transcription Factor, E2F4 Transcription Factor, E2F5 Transcription Factor, Gene Expression Regulation, Granulocyte Colony-Stimulating Factor, Granulocytes, Humans, Interleukin-3, Retinoblastoma-Binding Protein 1, Transcription Factor DP1, Transcription Factors, Tumor Cells, Cultured
Added June 10, 2010
1 Communities
1 Members
0 Resources
22 MeSH Terms
E2F-1 cooperates with topoisomerase II inhibition and DNA damage to selectively augment p53-independent apoptosis.
Nip J, Strom DK, Fee BE, Zambetti G, Cleveland JL, Hiebert SW
(1997) Mol Cell Biol 17: 1049-56
MeSH Terms: Antineoplastic Agents, Apoptosis, Bone Marrow Cells, Carrier Proteins, Cell Cycle, Cell Cycle Proteins, Cell Survival, DNA Damage, DNA-Binding Proteins, Doxorubicin, E2F Transcription Factors, E2F1 Transcription Factor, Enzyme Inhibitors, Etoposide, Fluorouracil, Gamma Rays, Gene Expression, Humans, Piperazines, Proto-Oncogene Proteins c-bcl-2, Retinoblastoma-Binding Protein 1, Topoisomerase II Inhibitors, Transcription Factor DP1, Transcription Factors, Tumor Suppressor Protein p53
Added June 10, 2010
1 Communities
1 Members
0 Resources
25 MeSH Terms
Indirect and direct disruption of transcriptional regulation in cancer: E2F and AML-1.
Meyers S, Hiebert SW
(1995) Crit Rev Eukaryot Gene Expr 5: 365-83
MeSH Terms: Carrier Proteins, Cell Cycle Proteins, Core Binding Factor Alpha 2 Subunit, DNA-Binding Proteins, E2F Transcription Factors, Gene Expression Regulation, Neoplastic, Humans, Neoplasms, Proto-Oncogene Proteins, Retinoblastoma-Binding Protein 1, Transcription Factor DP1, Transcription Factors, Transcription, Genetic
Added June 10, 2010
1 Communities
1 Members
0 Resources
13 MeSH Terms
E2F-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis.
Hiebert SW, Packham G, Strom DK, Haffner R, Oren M, Zambetti G, Cleveland JL
(1995) Mol Cell Biol 15: 6864-74
MeSH Terms: Animals, Apoptosis, Carrier Proteins, Cell Cycle Proteins, Cell Line, DNA Damage, DNA-Binding Proteins, Dexamethasone, E2F Transcription Factors, E2F1 Transcription Factor, Fibroblasts, Gene Expression, Humans, Interleukin-3, Kinetics, Recombinant Proteins, Retinoblastoma-Binding Protein 1, Time Factors, Transcription Factor DP1, Transcription Factors, Transfection, Tumor Suppressor Protein p53
Added June 10, 2010
1 Communities
1 Members
0 Resources
22 MeSH Terms
Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression.
Hiebert SW
(1993) Mol Cell Biol 13: 3384-91
MeSH Terms: Adenovirus E1A Proteins, Adenovirus E2 Proteins, Binding Sites, Carrier Proteins, Cell Cycle, Cell Cycle Proteins, Cell Division, DNA-Binding Proteins, E2F Transcription Factors, Female, G1 Phase, Genes, Retinoblastoma, Humans, Promoter Regions, Genetic, Retinoblastoma Protein, Retinoblastoma-Binding Protein 1, Transcription Factor DP1, Transcription Factors, Transfection, Tumor Cells, Cultured, Uterine Cervical Neoplasms
Added June 10, 2010
1 Communities
1 Members
0 Resources
21 MeSH Terms
Dual control of myc expression through a single DNA binding site targeted by ets family proteins and E2F-1.
Roussel MF, Davis JN, Cleveland JL, Ghysdael J, Hiebert SW
(1994) Oncogene 9: 405-15
MeSH Terms: Amino Acid Sequence, Animals, Base Sequence, Carrier Proteins, Cell Cycle Proteins, Cell Line, DNA, DNA-Binding Proteins, E2F Transcription Factors, E2F1 Transcription Factor, Electrophoresis, Fibroblasts, Gene Expression Regulation, Genes, myc, Mice, Molecular Sequence Data, Promoter Regions, Genetic, Protein Binding, Proto-Oncogene Protein c-ets-1, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-ets, Proto-Oncogene Proteins c-myc, Retinoblastoma-Binding Protein 1, S Phase, Transcription Factor DP1, Transcription Factors, Transcription, Genetic, Transcriptional Activation, Transfection
Added June 10, 2010
1 Communities
1 Members
0 Resources
29 MeSH Terms