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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 26

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Androgenic Effects on Ventricular Repolarization: A Translational Study From the International Pharmacovigilance Database to iPSC-Cardiomyocytes.
Salem JE, Yang T, Moslehi JJ, Waintraub X, Gandjbakhch E, Bachelot A, Hidden-Lucet F, Hulot JS, Knollmann BC, Lebrun-Vignes B, Funck-Brentano C, Glazer AM, Roden DM
(2019) Circulation 140: 1070-1080
MeSH Terms: Androgens, Antineoplastic Agents, Cell Differentiation, Cells, Cultured, Databases, Factual, Humans, Hypogonadism, Induced Pluripotent Stem Cells, International Cooperation, Long QT Syndrome, Male, Myocytes, Cardiac, Pharmacovigilance, Phenylthiohydantoin, Risk, Torsades de Pointes, Translational Medical Research
Added November 12, 2019
0 Communities
2 Members
0 Resources
17 MeSH Terms
Hypogonadism as a Reversible Cause of Torsades de Pointes in Men.
Salem JE, Waintraub X, Courtillot C, Shaffer CM, Gandjbakhch E, Maupain C, Moslehi JJ, Badilini F, Haroche J, Gougis P, Fressart V, Glazer AM, Hidden-Lucet F, Touraine P, Lebrun-Vignes B, Roden DM, Bachelot A, Funck-Brentano C
(2018) Circulation 138: 110-113
MeSH Terms: Adverse Drug Reaction Reporting Systems, Aged, Aged, 80 and over, Androgen Antagonists, Biomarkers, Cross-Sectional Studies, Databases, Factual, Electronic Health Records, Heart Rate, Hormone Replacement Therapy, Humans, Hypogonadism, Male, Middle Aged, Paris, Pharmacovigilance, Prospective Studies, Risk Assessment, Risk Factors, Testosterone, Torsades de Pointes
Added October 1, 2018
0 Communities
2 Members
0 Resources
21 MeSH Terms
Increased long QT and torsade de pointes reporting on tamoxifen compared with aromatase inhibitors.
Grouthier V, Lebrun-Vignes B, Glazer AM, Touraine P, Funck-Brentano C, Pariente A, Courtillot C, Bachelot A, Roden DM, Moslehi JJ, Salem JE
(2018) Heart 104: 1859-1863
MeSH Terms: Action Potentials, Adolescent, Adult, Adverse Drug Reaction Reporting Systems, Aged, Aged, 80 and over, Aromatase Inhibitors, Cardiotoxicity, Databases, Factual, Europe, Female, Heart Conduction System, Heart Rate, Humans, Long QT Syndrome, Middle Aged, Prognosis, Risk Assessment, Risk Factors, Selective Estrogen Receptor Modulators, Tamoxifen, Torsades de Pointes, Young Adult
Added October 1, 2018
0 Communities
2 Members
0 Resources
23 MeSH Terms
Common Genetic Variant Risk Score Is Associated With Drug-Induced QT Prolongation and Torsade de Pointes Risk: A Pilot Study.
Strauss DG, Vicente J, Johannesen L, Blinova K, Mason JW, Weeke P, Behr ER, Roden DM, Woosley R, Kosova G, Rosenberg MA, Newton-Cheh C
(2017) Circulation 135: 1300-1310
MeSH Terms: Adult, Arrhythmias, Cardiac, Female, Genome-Wide Association Study, Humans, Long QT Syndrome, Male, Pilot Projects, Polymorphism, Single Nucleotide, Risk Assessment, Torsades de Pointes
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Torsades de pointes with high-dose loperamide.
Kozak PM, Harris AE, McPherson JA, Roden DM
(2017) J Electrocardiol 50: 355-357
MeSH Terms: Adult, Chronic Pain, Diagnosis, Differential, Dose-Response Relationship, Drug, Electrocardiography, Humans, Loperamide, Male, Self Medication, Torsades de Pointes
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Finding a Needle in a QT Interval Big Data Haystack: The Role for Orthogonal Datasets.
Roden DM, Mosley JD, Denny JC
(2016) J Am Coll Cardiol 68: 1765-1768
MeSH Terms: Ether-A-Go-Go Potassium Channels, Humans, Long QT Syndrome, Potassium Channels, Voltage-Gated, Torsades de Pointes
Added March 14, 2018
0 Communities
2 Members
0 Resources
5 MeSH Terms
Predicting drug-induced QT prolongation and torsades de pointes.
Roden DM
(2016) J Physiol 594: 2459-68
MeSH Terms: Animals, Drug-Related Side Effects and Adverse Reactions, Humans, Long QT Syndrome, Myocytes, Cardiac, Torsades de Pointes
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
QT Prolongation and Oncology Drug Development.
Fradley MG, Moslehi J
(2015) Card Electrophysiol Clin 7: 341-55
MeSH Terms: Antineoplastic Agents, Cardiotoxins, Electrocardiography, Humans, Long QT Syndrome, Torsades de Pointes
Added March 6, 2016
0 Communities
1 Members
0 Resources
6 MeSH Terms
Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current.
Yang T, Chun YW, Stroud DM, Mosley JD, Knollmann BC, Hong C, Roden DM
(2014) Circulation 130: 224-34
MeSH Terms: 4-Aminopyridine, Action Potentials, Animals, CHO Cells, Cells, Cultured, Cricetinae, Cricetulus, Drug Evaluation, Preclinical, Female, HEK293 Cells, Humans, Mice, Mice, Inbred C57BL, Models, Animal, Myocytes, Cardiac, NAV1.5 Voltage-Gated Sodium Channel, Patch-Clamp Techniques, Phenethylamines, Phosphatidylinositol 3-Kinases, Potassium Channel Blockers, Proto-Oncogene Proteins c-akt, Risk Factors, Signal Transduction, Sulfonamides, Torsades de Pointes, Transfection
Added June 5, 2014
0 Communities
2 Members
0 Resources
26 MeSH Terms
Exome sequencing implicates an increased burden of rare potassium channel variants in the risk of drug-induced long QT interval syndrome.
Weeke P, Mosley JD, Hanna D, Delaney JT, Shaffer C, Wells QS, Van Driest S, Karnes JH, Ingram C, Guo Y, Shyr Y, Norris K, Kannankeril PJ, Ramirez AH, Smith JD, Mardis ER, Nickerson D, George AL, Roden DM
(2014) J Am Coll Cardiol 63: 1430-7
MeSH Terms: Adult, Aged, Alleles, Case-Control Studies, Drug-Related Side Effects and Adverse Reactions, Exome, Female, Genetic Predisposition to Disease, Genetic Variation, Genotype, Humans, Incidence, KCNQ1 Potassium Channel, Long QT Syndrome, Male, Middle Aged, Potassium Channels, Potassium Channels, Voltage-Gated, Predictive Value of Tests, Reference Values, Risk Assessment, Sequence Analysis, Protein, Torsades de Pointes
Added February 28, 2014
0 Communities
4 Members
0 Resources
23 MeSH Terms