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Results: 1 to 10 of 164

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Specificity and affinity of the N-terminal residues in staphylocoagulase in binding to prothrombin.
Maddur AA, Kroh HK, Aschenbrenner ME, Gibson BHY, Panizzi P, Sheehan JH, Meiler J, Bock PE, Verhamme IM
(2020) J Biol Chem 295: 5614-5625
MeSH Terms: Bacterial Proteins, Binding Sites, Coagulase, Humans, Models, Molecular, Protein Binding, Prothrombin, Staphylococcal Infections, Staphylococcus aureus, Substrate Specificity
Added March 21, 2020
0 Communities
1 Members
0 Resources
10 MeSH Terms
Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions.
Rigg RA, Healy LD, Chu TT, Ngo ATP, Mitrugno A, Zilberman-Rudenko J, Aslan JE, Hinds MT, Vecchiarelli LD, Morgan TK, Gruber A, Temple KJ, Lindsley CW, Duvernay MT, Hamm HE, McCarty OJT
(2019) Platelets 30: 126-135
MeSH Terms: Animals, Biomarkers, Blood Platelets, Cell Communication, Cytoplasmic Granules, Flow Cytometry, Humans, Leukocytes, Male, Papio, Platelet Activation, Platelet Aggregation, Receptors, Thrombin
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Contributions of Protease-Activated Receptors PAR1 and PAR4 to Thrombin-Induced GPIIbIIIa Activation in Human Platelets.
Duvernay MT, Temple KJ, Maeng JG, Blobaum AL, Stauffer SR, Lindsley CW, Hamm HE
(2017) Mol Pharmacol 91: 39-47
MeSH Terms: Blood Platelets, Humans, Integrin beta3, Ligands, Platelet Glycoprotein GPIb-IX Complex, Receptor, PAR-1, Receptors, Thrombin, Signal Transduction, Thrombin
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Identification of the minimum PAR4 inhibitor pharmacophore and optimization of a series of 2-methoxy-6-arylimidazo[2,1-b][1,3,4]thiadiazoles.
Temple KJ, Duvernay MT, Maeng JG, Blobaum AL, Stauffer SR, Hamm HE, Lindsley CW
(2016) Bioorg Med Chem Lett 26: 5481-5486
MeSH Terms: Blood Platelets, Humans, Platelet Aggregation, Platelet Aggregation Inhibitors, Receptors, Thrombin, Thiadiazoles, Thrombin
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Development of a Series of (1-Benzyl-3-(6-methoxypyrimidin-3-yl)-5-(trifluoromethoxy)-1H-indol-2-yl)methanols as Selective Protease Activated Receptor 4 (PAR4) Antagonists with in Vivo Utility and Activity Against γ-Thrombin.
Temple KJ, Duvernay MT, Young SE, Wen W, Wu W, Maeng JG, Blobaum AL, Stauffer SR, Hamm HE, Lindsley CW
(2016) J Med Chem 59: 7690-5
MeSH Terms: Dose-Response Relationship, Drug, Enzyme Inhibitors, Humans, Indoles, Molecular Structure, Pyrimidines, Receptors, Thrombin, Structure-Activity Relationship, Thrombin
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Thrombin induced by the extrinsic pathway and PAR-1 regulated inflammation at the site of fracture repair.
Sato N, Ichikawa J, Wako M, Ohba T, Saito M, Sato H, Koyama K, Hagino T, Schoenecker JG, Ando T, Haro H
(2016) Bone 83: 23-34
MeSH Terms: Animals, Cell Movement, Chemokine CCL2, Disease Models, Animal, Fracture Healing, Humans, Inflammation, Interleukin-6, MAP Kinase Signaling System, Male, Mice, Mice, Inbred C57BL, Models, Biological, Osteoblasts, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, RAW 264.7 Cells, Receptor, PAR-1, Thrombin, Thromboplastin
Added February 22, 2016
0 Communities
1 Members
0 Resources
20 MeSH Terms
Platelet Lipidomic Profiling: Novel Insight into Cytosolic Phospholipase A2α Activity and Its Role in Human Platelet Activation.
Duvernay MT, Matafonov A, Lindsley CW, Hamm HE
(2015) Biochemistry 54: 5578-88
MeSH Terms: Benzoates, Blood Platelets, Glycerophospholipids, Group IV Phospholipases A2, Humans, Lipids, Oligopeptides, Peptide Fragments, Platelet Activation, Platelet Membrane Glycoproteins, Receptor, PAR-1, Receptors, Thrombin, Spectrometry, Mass, Electrospray Ionization, Stress, Mechanical, Sulfonamides, Thrombin
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
The hyperglycemic byproduct methylglyoxal impairs anticoagulant activity through covalent adduction of antithrombin III.
Jacobson R, Mignemi N, Rose K, O'Rear L, Sarilla S, Hamm HE, Barnett JV, Verhamme IM, Schoenecker J
(2014) Thromb Res 134: 1350-7
MeSH Terms: Anticoagulants, Antithrombin III, Blood Coagulation, Dose-Response Relationship, Drug, Heparin, Humans, Hyperglycemia, Protein Binding, Pyruvaldehyde
Added January 20, 2015
0 Communities
4 Members
0 Resources
9 MeSH Terms
Factor XII inhibition reduces thrombus formation in a primate thrombosis model.
Matafonov A, Leung PY, Gailani AE, Grach SL, Puy C, Cheng Q, Sun MF, McCarty OJ, Tucker EI, Kataoka H, Renné T, Morrissey JH, Gruber A, Gailani D
(2014) Blood 123: 1739-46
MeSH Terms: Animals, Antibodies, Monoclonal, Blood Coagulation, Disease Models, Animal, Factor XI, Factor XII, Factor XII Deficiency, Factor XIIa, Fibrin, Humans, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Papio, Recombinant Proteins, Thrombin, Thromboplastin, Thrombosis
Added May 19, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Factor XI anion-binding sites are required for productive interactions with polyphosphate.
Geng Y, Verhamme IM, Smith SA, Cheng Q, Sun M, Sheehan JP, Morrissey JH, Gailani D
(2013) J Thromb Haemost 11: 2020-8
MeSH Terms: Animals, Anions, Antithrombins, Binding Sites, Blood Coagulation, Cattle, Factor IX, Factor XI, Factor XIa, Heparin, Humans, Mice, Mice, Inbred C57BL, Polyelectrolytes, Polymers, Polyphosphates, Recombinant Proteins, Thrombin, Thrombosis
Added May 19, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms