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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 40

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PEGylated PLGA Nanoparticle Delivery of Eggmanone for T Cell Modulation: Applications in Rheumatic Autoimmunity.
Haycook CP, Balsamo JA, Glass EB, Williams CH, Hong CC, Major AS, Giorgio TD
(2020) Int J Nanomedicine 15: 1215-1228
MeSH Terms: Animals, Autoimmunity, CD4-Positive T-Lymphocytes, Cytokines, Drug Delivery Systems, Female, Hedgehog Proteins, Immunoglobulin Fragments, Immunologic Factors, Mice, Inbred C57BL, Nanoparticles, Polylactic Acid-Polyglycolic Acid Copolymer, Pyrimidinones, Rheumatic Diseases, T-Lymphocytes, T-Lymphocytes, Helper-Inducer, Thiophenes
Added March 30, 2020
0 Communities
1 Members
0 Resources
17 MeSH Terms
Tuning Ligand Density To Optimize Pharmacokinetics of Targeted Nanoparticles for Dual Protection against Tumor-Induced Bone Destruction.
Vanderburgh J, Hill JL, Gupta MK, Kwakwa KA, Wang SK, Moyer K, Bedingfield SK, Merkel AR, d'Arcy R, Guelcher SA, Rhoades JA, Duvall CL
(2020) ACS Nano 14: 311-327
MeSH Terms: Animals, Antineoplastic Agents, Bone Neoplasms, Cell Line, Tumor, Cell Proliferation, Disease Models, Animal, Drug Screening Assays, Antitumor, Female, Humans, Ligands, Mice, Mice, Inbred C57BL, Mice, Knockout, Nanoparticles, Optical Imaging, Particle Size, Polymers, Pyridines, Surface Properties, Thiophenes, X-Ray Microtomography
Added March 19, 2020
0 Communities
3 Members
0 Resources
21 MeSH Terms
The peroxisome proliferator-activated receptor-β/δ antagonist GSK0660 mitigates retinal cell inflammation and leukostasis.
Capozzi ME, Savage SR, McCollum GW, Hammer SS, Ramos CJ, Yang R, Bretz CA, Penn JS
(2020) Exp Eye Res 190: 107885
MeSH Terms: Adult, Animals, Cells, Cultured, Cytokines, Endothelial Cells, Ependymoglial Cells, Humans, Inflammation, Leukostasis, Male, Mice, Mice, Inbred C57BL, PPAR delta, PPAR-beta, Palmitic Acids, Real-Time Polymerase Chain Reaction, Retina, Retinitis, Sulfones, Thiophenes
Added March 30, 2020
0 Communities
1 Members
0 Resources
20 MeSH Terms
Systemic delivery of a Gli inhibitor via polymeric nanocarriers inhibits tumor-induced bone disease.
Vanderburgh JP, Kwakwa KA, Werfel TA, Merkel AR, Gupta MK, Johnson RW, Guelcher SA, Duvall CL, Rhoades JA
(2019) J Control Release 311-312: 257-272
MeSH Terms: Animals, Antineoplastic Agents, Apoptosis, Bone Neoplasms, Cell Line, Tumor, Cell Proliferation, Cell Survival, Drug Carriers, Drug Liberation, Female, Gene Expression Regulation, Neoplastic, Humans, Mammary Neoplasms, Animal, Mesenchymal Stem Cells, Mice, Inbred C57BL, Mice, Knockout, Mice, Nude, Nanoparticles, Osteogenesis, Polymers, Pyridines, Thiophenes, Zinc Finger Protein Gli2
Added March 3, 2020
0 Communities
4 Members
0 Resources
23 MeSH Terms
Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer's disease.
Roby DA, Ruiz F, Kermath BA, Voorhees JR, Niehoff M, Zhang J, Morley JE, Musiek ES, Farr SA, Burris TP
(2019) PLoS One 14: e0215004
MeSH Terms: Alzheimer Disease, Amyloid beta-Peptides, Animals, Cognitive Dysfunction, Disease Models, Animal, Disks Large Homolog 4 Protein, Hippocampus, Male, Mice, Nuclear Receptor Subfamily 1, Group D, Member 1, Peptide Fragments, Pyrrolidines, Thiophenes
Added April 30, 2019
0 Communities
1 Members
0 Resources
13 MeSH Terms
Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M PAM VU0467154.
Gould RW, Grannan MD, Gunter BW, Ball J, Bubser M, Bridges TM, Wess J, Wood MW, Brandon NJ, Duggan ME, Niswender CM, Lindsley CW, Conn PJ, Jones CK
(2018) Neuropharmacology 128: 492-502
MeSH Terms: Allosteric Regulation, Animals, Antipsychotic Agents, Brain, Cognition Disorders, Discrimination, Psychological, Disease Models, Animal, Dizocilpine Maleate, Dose-Response Relationship, Drug, Hyperkinesis, Male, Memory Disorders, Mice, Mice, Inbred C57BL, Mice, Knockout, Pyridazines, Receptor, Muscarinic M4, Schizophrenia, Thiophenes
Added March 3, 2020
0 Communities
2 Members
0 Resources
MeSH Terms
Optimization of M positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology.
Melancon BJ, Wood MR, Noetzel MJ, Nance KD, Engelberg EM, Han C, Lamsal A, Chang S, Cho HP, Byers FW, Bubser M, Jones CK, Niswender CM, Wood MW, Engers DW, Wu D, Brandon NJ, Duggan ME, Conn PJ, Bridges TM, Lindsley CW
(2017) Bioorg Med Chem Lett 27: 2296-2301
MeSH Terms: Allosteric Regulation, Animals, Crystallography, X-Ray, Drug Discovery, Hydrogen Bonding, Pyridazines, Rats, Structure-Activity Relationship, Thiophenes, Translational Research, Biomedical
Added March 3, 2020
0 Communities
2 Members
0 Resources
10 MeSH Terms
Challenges in the development of an M PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs.
Wood MR, Noetzel MJ, Poslusney MS, Melancon BJ, Tarr JC, Lamsal A, Chang S, Luscombe VB, Weiner RL, Cho HP, Bubser M, Jones CK, Niswender CM, Wood MW, Engers DW, Brandon NJ, Duggan ME, Conn PJ, Bridges TM, Lindsley CW
(2017) Bioorg Med Chem Lett 27: 171-175
MeSH Terms: Animals, Humans, Ligands, Nucleoside Transport Proteins, Pyridazines, Rats, Sprague-Dawley, Receptor, Muscarinic M4, Structure-Activity Relationship, Thiophenes
Added April 6, 2017
0 Communities
3 Members
0 Resources
9 MeSH Terms
Safety evaluation of substituted thiophenes used as flavoring ingredients.
Cohen SM, Fukushima S, Gooderham NJ, Guengerich FP, Hecht SS, Rietjens IM, Smith RL, Bastaki M, Harman CL, McGowen MM, Valerio LG, Taylor SV
(2017) Food Chem Toxicol 99: 40-59
MeSH Terms: Consumer Product Safety, Flavoring Agents, Humans, No-Observed-Adverse-Effect Level, Thiophenes, Toxicity Tests, United States, United States Food and Drug Administration
Added March 14, 2018
0 Communities
1 Members
0 Resources
8 MeSH Terms
Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release.
Foster DJ, Wilson JM, Remke DH, Mahmood MS, Uddin MJ, Wess J, Patel S, Marnett LJ, Niswender CM, Jones CK, Xiang Z, Lindsley CW, Rook JM, Conn PJ
(2016) Neuron 91: 1244-1252
MeSH Terms: Allosteric Regulation, Animals, Antipsychotic Agents, Corpus Striatum, Dopamine, Lipoprotein Lipase, Mice, Knockout, Muscarinic Agonists, Oxotremorine, Prepulse Inhibition, Pyridazines, Receptor, Cannabinoid, CB2, Receptor, Muscarinic M4, Thiophenes
Added April 6, 2017
0 Communities
6 Members
0 Resources
14 MeSH Terms