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Lipopolysaccharide Induced Opening of the Blood Brain Barrier on Aging 5XFAD Mouse Model.
Barton SM, Janve VA, McClure R, Anderson A, Matsubara JA, Gore JC, Pham W
(2019) J Alzheimers Dis 67: 503-513
MeSH Terms: Aging, Alzheimer Disease, Amyloid beta-Peptides, Animals, Benzothiazoles, Biological Availability, Blood-Brain Barrier, Ferric Compounds, Humans, Inflammation, Lipopolysaccharides, Mice, Mice, Inbred C57BL, Mice, Transgenic, Nanoparticles, Permeability, Plaque, Amyloid
Added March 26, 2019
0 Communities
2 Members
0 Resources
17 MeSH Terms
Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness.
Girard TD, Exline MC, Carson SS, Hough CL, Rock P, Gong MN, Douglas IS, Malhotra A, Owens RL, Feinstein DJ, Khan B, Pisani MA, Hyzy RC, Schmidt GA, Schweickert WD, Hite RD, Bowton DL, Masica AL, Thompson JL, Chandrasekhar R, Pun BT, Strength C, Boehm LM, Jackson JC, Pandharipande PP, Brummel NE, Hughes CG, Patel MB, Stollings JL, Bernard GR, Dittus RS, Ely EW, MIND-USA Investigators
(2018) N Engl J Med 379: 2506-2516
MeSH Terms: Aged, Antipsychotic Agents, Critical Illness, Delirium, Dopamine Antagonists, Double-Blind Method, Female, Haloperidol, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Piperazines, Respiratory Insufficiency, Shock, Thiazoles, Treatment Failure
Added October 23, 2018
0 Communities
2 Members
0 Resources
17 MeSH Terms
Von Hippel-Lindau mutations disrupt vascular patterning and maturation via Notch.
Arreola A, Payne LB, Julian MH, de Cubas AA, Daniels AB, Taylor S, Zhao H, Darden J, Bautch VL, Rathmell WK, Chappell JC
(2018) JCI Insight 3:
MeSH Terms: Animals, Diamines, Disease Models, Animal, Endothelial Cells, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Hemangioblastoma, Humans, Male, Mice, Mice, Transgenic, Microvessels, Mutation, Receptors, Notch, Retinal Artery, Thiazoles, Von Hippel-Lindau Tumor Suppressor Protein, von Hippel-Lindau Disease
Added October 30, 2019
0 Communities
2 Members
0 Resources
19 MeSH Terms
Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice.
Ade KK, Wan Y, Hamann HC, O'Hare JK, Guo W, Quian A, Kumar S, Bhagat S, Rodriguiz RM, Wetsel WC, Conn PJ, Dzirasa K, Huber KM, Calakos N
(2016) Biol Psychiatry 80: 522-33
MeSH Terms: Animals, Behavior, Animal, Corpus Striatum, Excitatory Amino Acid Agonists, Excitatory Amino Acid Antagonists, Glycine, Grooming, Mice, Mice, Knockout, Mice, Transgenic, Nerve Tissue Proteins, Niacinamide, Obsessive-Compulsive Disorder, Pyridines, Receptor, Metabotropic Glutamate 5, Signal Transduction, Thiazoles
Added April 6, 2017
0 Communities
1 Members
0 Resources
17 MeSH Terms
A Phase Ib Study of Alpelisib (BYL719), a PI3Kα-Specific Inhibitor, with Letrozole in ER+/HER2- Metastatic Breast Cancer.
Mayer IA, Abramson VG, Formisano L, Balko JM, Estrada MV, Sanders ME, Juric D, Solit D, Berger MF, Won HH, Li Y, Cantley LC, Winer E, Arteaga CL
(2017) Clin Cancer Res 23: 26-34
MeSH Terms: Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Aromatase Inhibitors, Biomarkers, Tumor, Breast Neoplasms, Cell Line, Tumor, DNA Mutational Analysis, Female, Humans, In Situ Hybridization, Fluorescence, Letrozole, Maximum Tolerated Dose, Middle Aged, Mutation, Neoplasm Metastasis, Neoplasm Staging, Nitriles, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Receptor, ErbB-2, Receptor, Fibroblast Growth Factor, Type 1, Receptors, Estrogen, Thiazoles, Treatment Outcome, Triazoles
Added April 6, 2017
0 Communities
1 Members
0 Resources
26 MeSH Terms
The Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator ADX88178 Inhibits Inflammatory Responses in Primary Microglia.
Ponnazhagan R, Harms AS, Thome AD, Jurkuvenaite A, Gogliotti R, Niswender CM, Conn PJ, Standaert DG
(2016) J Neuroimmune Pharmacol 11: 231-7
MeSH Terms: Allosteric Regulation, Animals, Anti-Inflammatory Agents, Cells, Cultured, Dose-Response Relationship, Drug, Inflammation, Inflammation Mediators, Mice, Mice, Inbred C57BL, Mice, Knockout, Microglia, Pyrimidines, Receptors, Metabotropic Glutamate, Thiazoles
Added April 6, 2017
0 Communities
2 Members
0 Resources
14 MeSH Terms
Partial mGlu₅ Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like Effects.
Gould RW, Amato RJ, Bubser M, Joffe ME, Nedelcovych MT, Thompson AD, Nickols HH, Yuh JP, Zhan X, Felts AS, Rodriguez AL, Morrison RD, Byers FW, Rook JM, Daniels JS, Niswender CM, Conn PJ, Emmitte KA, Lindsley CW, Jones CK
(2016) Neuropsychopharmacology 41: 1166-78
MeSH Terms: Alkynes, Allosteric Regulation, Animals, Anti-Anxiety Agents, Antidepressive Agents, Brain, Cocaine, Conditioning, Classical, Conditioning, Operant, Dose-Response Relationship, Drug, Drug-Seeking Behavior, Male, Mice, Motor Activity, Phencyclidine, Pyridines, Rats, Sprague-Dawley, Receptor, Metabotropic Glutamate 5, Self Administration, Thiazoles
Added February 18, 2016
0 Communities
4 Members
0 Resources
20 MeSH Terms
Voxelwise Relationships Between Distribution Volume Ratio and Cerebral Blood Flow: Implications for Analysis of β-Amyloid Images.
Sojkova J, Goh J, Bilgel M, Landman B, Yang X, Zhou Y, An Y, Beason-Held LL, Kraut MA, Wong DF, Resnick SM
(2015) J Nucl Med 56: 1042-7
MeSH Terms: Aged, Aged, 80 and over, Amyloid beta-Peptides, Aniline Compounds, Benzothiazoles, Carbon Isotopes, Cerebrovascular Circulation, False Positive Reactions, Female, Humans, Image Processing, Computer-Assisted, Linear Models, Longitudinal Studies, Male, Middle Aged, Oxygen Isotopes, Positron-Emission Tomography, Reference Values, Reproducibility of Results, Thiazoles, Water
Added November 2, 2016
0 Communities
1 Members
0 Resources
21 MeSH Terms
Modeling clustered activity increase in amyloid-beta positron emission tomographic images with statistical descriptors.
Shokouhi S, Rogers BP, Kang H, Ding Z, Claassen DO, Mckay JW, Riddle WR, Alzheimer's Disease Neuroimaging Initiative
(2015) Clin Interv Aging 10: 759-70
MeSH Terms: Aged, Aged, 80 and over, Alzheimer Disease, Amyloid beta-Peptides, Aniline Compounds, Benzothiazoles, Brain, Cerebrospinal Fluid, Female, Humans, Image Processing, Computer-Assisted, Male, Models, Statistical, Positron-Emission Tomography, Thiazoles
Added April 6, 2017
0 Communities
1 Members
0 Resources
15 MeSH Terms
Thiobenzothiazole-modified Hydrocortisones Display Anti-inflammatory Activity with Reduced Impact on Islet β-Cell Function.
Burke SJ, May AL, Noland RC, Lu D, Brissova M, Powers AC, Sherrill EM, Karlstad MD, Campagna SR, Stephens JM, Collier JJ
(2015) J Biol Chem 290: 13401-16
MeSH Terms: 3T3-L1 Cells, Animals, Anti-Inflammatory Agents, Apoptosis, Benzimidazoles, Benzothiazoles, Blotting, Western, Cell Proliferation, Cells, Cultured, Dexamethasone, Gene Expression Profiling, Hepatocytes, Humans, Hydrocortisone, Immunoenzyme Techniques, Inflammation, Insulin, Insulin Secretion, Islets of Langerhans, Metabolomics, Mice, Mice, Inbred C57BL, Oxygen Consumption, RNA, Messenger, Rats, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Thiazoles
Added July 28, 2015
1 Communities
1 Members
0 Resources
28 MeSH Terms