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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 9 of 9

Publication Record

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Classics in Chemical Neuroscience: Xanomeline.
Bender AM, Jones CK, Lindsley CW
(2017) ACS Chem Neurosci 8: 435-443
MeSH Terms: Animals, Central Nervous System Diseases, Humans, Muscarinic Agonists, Neurosciences, Pyridines, Thiadiazoles
Added March 18, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Identification of the minimum PAR4 inhibitor pharmacophore and optimization of a series of 2-methoxy-6-arylimidazo[2,1-b][1,3,4]thiadiazoles.
Temple KJ, Duvernay MT, Maeng JG, Blobaum AL, Stauffer SR, Hamm HE, Lindsley CW
(2016) Bioorg Med Chem Lett 26: 5481-5486
MeSH Terms: Blood Platelets, Humans, Platelet Aggregation, Platelet Aggregation Inhibitors, Receptors, Thrombin, Thiadiazoles, Thrombin
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Specific deletion of glycogen synthase kinase-3β in the renal proximal tubule protects against acute nephrotoxic injury in mice.
Howard C, Tao S, Yang HC, Fogo AB, Woodgett JR, Harris RC, Rao R
(2012) Kidney Int 82: 1000-9
MeSH Terms: Acute Disease, Acute Kidney Injury, Animals, Anti-Infective Agents, Local, Apoptosis, Cell Proliferation, Disease Models, Animal, Female, Gene Deletion, Glycogen Synthase Kinase 3, Glycogen Synthase Kinase 3 beta, Kaplan-Meier Estimate, Kidney Tubules, Proximal, Mercuric Chloride, Mice, Mice, Inbred C57BL, Mice, Knockout, Thiadiazoles
Added August 19, 2013
1 Communities
1 Members
0 Resources
18 MeSH Terms
Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012.
Melancon BJ, Utley TJ, Sevel C, Mattmann ME, Cheung YY, Bridges TM, Morrison RD, Sheffler DJ, Niswender CM, Daniels JS, Conn PJ, Lindsley CW, Wood MR
(2012) Bioorg Med Chem Lett 22: 5035-40
MeSH Terms: Animals, Azabicyclo Compounds, Azetidines, Cytochrome P-450 Enzyme System, Humans, Molecular Probes, Protein Binding, Protein Isoforms, Rats, Receptor, Muscarinic M1, Structure-Activity Relationship, Sulfonamides, Thiadiazoles
Added March 7, 2014
1 Communities
3 Members
0 Resources
13 MeSH Terms
Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells.
Le A, Lane AN, Hamaker M, Bose S, Gouw A, Barbi J, Tsukamoto T, Rojas CJ, Slusher BS, Zhang H, Zimmerman LJ, Liebler DC, Slebos RJ, Lorkiewicz PK, Higashi RM, Fan TW, Dang CV
(2012) Cell Metab 15: 110-21
MeSH Terms: B-Lymphocytes, Carbon Isotopes, Cell Hypoxia, Cell Line, Tumor, Cell Proliferation, Cell Survival, Citric Acid, Citric Acid Cycle, Fumarates, Glucose, Glutaminase, Glutamine, Humans, Isotope Labeling, Malates, Oxidation-Reduction, Sulfides, Thiadiazoles
Added March 12, 2014
0 Communities
2 Members
0 Resources
18 MeSH Terms
Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling.
Ni TT, Rellinger EJ, Mukherjee A, Xie S, Stephens L, Thorne CA, Kim K, Hu J, Lee E, Marnett L, Hatzopoulos AK, Zhong TP
(2011) Chem Biol 18: 1658-68
MeSH Terms: Animals, Cell Differentiation, Embryo, Nonmammalian, Embryonic Development, Embryonic Stem Cells, Heart, Mice, Myocytes, Cardiac, Signal Transduction, Thiadiazoles, Triazoles, Wnt Proteins, Zebrafish, Zebrafish Proteins, beta Catenin
Added November 13, 2012
1 Communities
0 Members
0 Resources
15 MeSH Terms
The antipsychotic potential of muscarinic allosteric modulation.
Bridges TM, LeBois EP, Hopkins CR, Wood MR, Jones CK, Conn PJ, Lindsley CW
(2010) Drug News Perspect 23: 229-40
MeSH Terms: Allosteric Regulation, Amino Acid Sequence, Animals, Antipsychotic Agents, Humans, Molecular Sequence Data, Pyridines, Receptors, Muscarinic, Schizophrenia, Thiadiazoles
Added February 19, 2015
0 Communities
2 Members
0 Resources
10 MeSH Terms
Discovery and development of a potent and highly selective small molecule muscarinic acetylcholine receptor subtype I (mAChR 1 or M1) antagonist in vitro and in vivo probe.
Weaver CD, Sheffler DJ, Lewis LM, Bridges TM, Williams R, Nalywajko NT, Kennedy JP, Mulder MM, Jadhav S, Aldrich LA, Jones CK, Marlo JE, Niswender CM, Mock MM, Zheng F, Conn PJ, Lindsley CW
(2009) Curr Top Med Chem 9: 1217-26
MeSH Terms: Drug Discovery, High-Throughput Screening Assays, Receptor, Muscarinic M1, Substrate Specificity, Sulfonamides, Thiadiazoles
Added February 16, 2015
0 Communities
3 Members
0 Resources
6 MeSH Terms
A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning.
Sheffler DJ, Williams R, Bridges TM, Xiang Z, Kane AS, Byun NE, Jadhav S, Mock MM, Zheng F, Lewis LM, Jones CK, Niswender CM, Weaver CD, Lindsley CW, Conn PJ
(2009) Mol Pharmacol 76: 356-68
MeSH Terms: Animals, Binding, Competitive, CHO Cells, Cricetinae, Cricetulus, Dose-Response Relationship, Drug, Electrophysiology, Hippocampus, Inhibitory Concentration 50, Learning, Male, Mice, Molecular Structure, Muscarinic Antagonists, Patch-Clamp Techniques, Rats, Rats, Sprague-Dawley, Receptor, Muscarinic M1, Seizures, Sensitivity and Specificity, Sulfonamides, Thiadiazoles
Added March 5, 2014
1 Communities
5 Members
0 Resources
22 MeSH Terms