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Primary prevention of venous thromboembolism with apixaban for multiple myeloma patients receiving immunomodulatory agents.
Cornell RF, Goldhaber SZ, Engelhardt BG, Moslehi J, Jagasia M, Harrell S, Rubinstein SM, Hall R, Wyatt H, Piazza G
(2020) Br J Haematol 190: 555-561
MeSH Terms: Aged, Comorbidity, Consolidation Chemotherapy, Factor Xa Inhibitors, Female, Hemorrhage, Humans, Immunologic Factors, Lenalidomide, Maintenance Chemotherapy, Male, Middle Aged, Multiple Myeloma, Myocardial Infarction, Pilot Projects, Proof of Concept Study, Prospective Studies, Pulmonary Embolism, Pyrazoles, Pyridones, Stroke, Thalidomide, Thrombophilia, Venous Thromboembolism, Venous Thrombosis
Added May 29, 2020
0 Communities
1 Members
0 Resources
25 MeSH Terms
The Dihydroxy Metabolite of the Teratogen Thalidomide Causes Oxidative DNA Damage.
Wani TH, Chakrabarty A, Shibata N, Yamazaki H, Guengerich FP, Chowdhury G
(2017) Chem Res Toxicol 30: 1622-1628
MeSH Terms: Catalase, DNA Cleavage, DNA Damage, Free Radical Scavengers, HEK293 Cells, Hep G2 Cells, Human Umbilical Vein Endothelial Cells, Humans, Microscopy, Fluorescence, Plasmids, Poly(ADP-ribose) Polymerases, Reactive Oxygen Species, Teratogens, Thalidomide
Added March 14, 2018
0 Communities
1 Members
0 Resources
14 MeSH Terms
Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity.
Murayama N, Kazuki Y, Satoh D, Arata K, Harada T, Shibata N, Guengerich FP, Yamazaki H
(2017) J Toxicol Sci 42: 343-348
MeSH Terms: Cells, Cultured, Cytochrome P-450 CYP3A, Enzyme Induction, Female, Humans, Liver, Oxidation-Reduction, Placenta, Pregnancy, Pregnane X Receptor, RNA, Messenger, Receptors, Steroid, Rifampin, Thalidomide
Added March 14, 2018
0 Communities
1 Members
0 Resources
14 MeSH Terms
Metabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice.
Shimizu M, Suemizu H, Mitsui M, Shibata N, Guengerich FP, Yamazaki H
(2017) Xenobiotica 47: 844-848
MeSH Terms: Angiogenesis Inhibitors, Animals, Cytochrome P-450 Enzyme System, Glucuronides, Hepatocytes, Humans, Liver, Metabolome, Mice, Microsomes, Liver, Thalidomide
Added March 14, 2018
0 Communities
1 Members
0 Resources
11 MeSH Terms
Cardiovascular and Thrombotic Complications of Novel Multiple Myeloma Therapies: A Review.
Li W, Garcia D, Cornell RF, Gailani D, Laubach J, Maglio ME, Richardson PG, Moslehi J
(2017) JAMA Oncol 3: 980-988
MeSH Terms: Antineoplastic Agents, Cardiovascular Diseases, Humans, Immunologic Factors, Lenalidomide, Multiple Myeloma, Proteasome Inhibitors, Risk Factors, Thalidomide, Thromboembolism, Thrombosis
Added March 26, 2017
0 Communities
1 Members
0 Resources
11 MeSH Terms
Assessment of Protein Binding of 5-Hydroxythalidomide Bioactivated in Humanized Mice with Human P450 3A-Chromosome or Hepatocytes by Two-Dimensional Electrophoresis/Accelerator Mass Spectrometry.
Yamazaki H, Suemizu H, Kazuki Y, Oofusa K, Kuribayashi S, Shimizu M, Ninomiya S, Horie T, Shibata N, Guengerich FP
(2016) Chem Res Toxicol 29: 1279-81
MeSH Terms: Animals, Cytochrome P-450 Enzyme System, Electrophoresis, Gel, Two-Dimensional, Hepatocytes, Humans, Mass Spectrometry, Mice, Protein Binding, Thalidomide
Added March 14, 2018
0 Communities
1 Members
0 Resources
9 MeSH Terms
Combining Chimeric Mice with Humanized Liver, Mass Spectrometry, and Physiologically-Based Pharmacokinetic Modeling in Toxicology.
Yamazaki H, Suemizu H, Mitsui M, Shimizu M, Guengerich FP
(2016) Chem Res Toxicol 29: 1903-1911
MeSH Terms: Activation, Metabolic, Animals, Chimera, Cytochrome P-450 Enzyme System, Humans, Liver, Mass Spectrometry, Mice, Thalidomide, Toxicokinetics
Added March 14, 2018
0 Communities
1 Members
0 Resources
10 MeSH Terms
Venous thromboembolism in hematopoietic stem cell transplant recipients.
Chaturvedi S, Neff A, Nagler A, Savani U, Mohty M, Savani BN
(2016) Bone Marrow Transplant 51: 473-8
MeSH Terms: Allografts, Graft vs Host Disease, Hematopoietic Stem Cell Transplantation, Humans, Lenalidomide, Multiple Myeloma, Postoperative Complications, Thalidomide, Venous Thromboembolism
Added April 25, 2016
0 Communities
1 Members
0 Resources
9 MeSH Terms
Simulation of Human Plasma Concentrations of Thalidomide and Primary 5-Hydroxylated Metabolites Explored with Pharmacokinetic Data in Humanized TK-NOG Mice.
Nishiyama S, Suemizu H, Shibata N, Guengerich FP, Yamazaki H
(2015) Chem Res Toxicol 28: 2088-90
MeSH Terms: Animals, Cytochrome P-450 CYP3A, Glutathione, Hepatocytes, Humans, Hydroxylation, Liver, Mice, Teratogens, Thalidomide
Added March 14, 2018
0 Communities
1 Members
0 Resources
10 MeSH Terms
Increased serum tumor necrosis factor α levels in patients with lenalidomide-induced hypothyroidism.
Iams WT, Hames ML, Tsai JP, Dahlman KB, Talbott MS, Richards KL, Reddy NM
(2015) Exp Hematol 43: 74-8
MeSH Terms: Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal, Murine-Derived, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Female, Humans, Hypothyroidism, Immunologic Factors, Interferon-gamma, Interleukin-12, Interleukin-15, Interleukin-6, Lenalidomide, Lymphoma, Large B-Cell, Diffuse, Male, Middle Aged, Rituximab, Severity of Illness Index, Thalidomide, Tumor Necrosis Factor-alpha
Added February 13, 2015
0 Communities
1 Members
0 Resources
23 MeSH Terms