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Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation.
Healey DCC, Cephus JY, Barone SM, Chowdhury NU, Dahunsi DO, Madden MZ, Ye X, Yu X, Olszewski K, Young K, Gerriets VA, Siska PJ, Dworski R, Hemler J, Locasale JW, Poyurovsky MV, Peebles RS, Irish JM, Newcomb DC, Rathmell JC
(2021) J Immunol 206: 1127-1139
MeSH Terms: Adult, Alternaria, Animals, Asthma, Biomarkers, Blood Glucose, Bronchoalveolar Lavage Fluid, Case-Control Studies, Cells, Cultured, Dexamethasone, Disease Models, Animal, Drug Synergism, Female, Glucose Transporter Type 1, Glutaminase, Glutamine, Healthy Volunteers, Humans, Immunosuppressive Agents, Lung, Male, Mice, Middle Aged, Primary Cell Culture, Pyroglyphidae, Th17 Cells, Th2 Cells, Young Adult
Added March 26, 2021
3 Communities
1 Members
0 Resources
28 MeSH Terms
The Innate Immune Protein S100A9 Protects from T-Helper Cell Type 2-mediated Allergic Airway Inflammation.
Palmer LD, Maloney KN, Boyd KL, Goleniewska AK, Toki S, Maxwell CN, Chazin WJ, Peebles RS, Newcomb DC, Skaar EP
(2019) Am J Respir Cell Mol Biol 61: 459-468
MeSH Terms: Adaptive Immunity, Allergens, Alternaria, Alveolitis, Extrinsic Allergic, Animals, Bronchial Hyperreactivity, Bronchoalveolar Lavage Fluid, Calgranulin A, Calgranulin B, Cytokines, Forkhead Transcription Factors, Immunoglobulin E, Inflammation, Leukocyte L1 Antigen Complex, Lung, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Pulmonary Eosinophilia, Specific Pathogen-Free Organisms, T-Lymphocytes, Regulatory, Th2 Cells
Added April 7, 2019
0 Communities
2 Members
0 Resources
23 MeSH Terms
Mucus T helper 2 biomarkers predict chronic rhinosinusitis disease severity and prior surgical intervention.
Turner JH, Li P, Chandra RK
(2018) Int Forum Allergy Rhinol 8: 1175-1183
MeSH Terms: Biomarkers, Chronic Disease, Female, Humans, Interleukin-13, Interleukin-5, Male, Middle Aged, Mucus, Nasal Mucosa, Nasal Polyps, Prospective Studies, Rhinitis, Sinusitis, Th2 Cells
Added July 23, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Definition of Human Epitopes Recognized in Tetanus Toxoid and Development of an Assay Strategy to Detect Ex Vivo Tetanus CD4+ T Cell Responses.
da Silva Antunes R, Paul S, Sidney J, Weiskopf D, Dan JM, Phillips E, Mallal S, Crotty S, Sette A, Lindestam Arlehamn CS
(2017) PLoS One 12: e0169086
MeSH Terms: Adult, Epitope Mapping, Epitopes, T-Lymphocyte, Female, Humans, Immunoassay, Immunologic Memory, Male, Tetanus Toxoid, Th1 Cells, Th2 Cells
Added March 30, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Prostaglandin I2 Suppresses Proinflammatory Chemokine Expression, CD4 T Cell Activation, and STAT6-Independent Allergic Lung Inflammation.
Zhou W, Zhang J, Goleniewska K, Dulek DE, Toki S, Newcomb DC, Cephus JY, Collins RD, Wu P, Boothby MR, Peebles RS
(2016) J Immunol 197: 1577-86
MeSH Terms: Allergens, Animals, Antihypertensive Agents, Asthma, CD4-Positive T-Lymphocytes, Cell Proliferation, Chemokines, Epoprostenol, Hypersensitivity, Indomethacin, Inflammation, Interleukin-13, Interleukin-5, Lung, Lymphocyte Activation, Mice, Mice, Inbred BALB C, Mice, Knockout, Ovalbumin, Receptors, Epoprostenol, STAT6 Transcription Factor, Signal Transduction, Th2 Cells
Added March 14, 2018
0 Communities
1 Members
0 Resources
23 MeSH Terms
TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization.
Caballero MT, Serra ME, Acosta PL, Marzec J, Gibbons L, Salim M, Rodriguez A, Reynaldi A, Garcia A, Bado D, Buchholz UJ, Hijano DR, Coviello S, Newcomb D, Bellabarba M, Ferolla FM, Libster R, Berenstein A, Siniawaski S, Blumetti V, Echavarria M, Pinto L, Lawrence A, Ossorio MF, Grosman A, Mateu CG, Bayle C, Dericco A, Pellegrini M, Igarza I, Repetto HA, Grimaldi LA, Gudapati P, Polack NR, Althabe F, Shi M, Ferrero F, Bergel E, Stein RT, Peebles RS, Boothby M, Kleeberger SR, Polack FP
(2015) J Clin Invest 125: 571-82
MeSH Terms: Animals, Bronchiolitis, Viral, Disease Models, Animal, Environmental Exposure, Female, GATA3 Transcription Factor, Genotype, Humans, Infant, Infant, Newborn, Interferon-gamma, Interleukin-4, Lipopolysaccharides, Male, Mice, Respiratory Syncytial Virus Infections, Respiratory Syncytial Viruses, T-Box Domain Proteins, Th2 Cells, Toll-Like Receptor 4
Added January 20, 2015
0 Communities
2 Members
0 Resources
20 MeSH Terms
Simultaneous inhibition of T helper 2 and T regulatory cell differentiation by small molecules enhances Bacillus Calmette-Guerin vaccine efficacy against tuberculosis.
Bhattacharya D, Dwivedi VP, Kumar S, Reddy MC, Van Kaer L, Moodley P, Das G
(2014) J Biol Chem 289: 33404-11
MeSH Terms: Animals, Anti-Allergic Agents, Arylsulfonates, Benzamides, Cell Differentiation, Imidazoles, Mice, Mice, Inbred BALB C, Mycobacterium bovis, Mycobacterium tuberculosis, Sulfonium Compounds, T-Lymphocytes, Regulatory, Th2 Cells, Tuberculosis Vaccines, Tuberculosis, Pulmonary
Added January 20, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms
STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge.
Dulek DE, Newcomb DC, Toki S, Goliniewska K, Cephus J, Reiss S, Bates JT, Crowe JE, Boyd KL, Moore ML, Zhou W, Peebles RS
(2014) J Virol 88: 9655-72
MeSH Terms: Animals, CD8-Positive T-Lymphocytes, Disease Models, Animal, Female, Lung, Mice, Inbred BALB C, Mice, Knockout, Respiratory Syncytial Virus Infections, Respiratory Syncytial Viruses, STAT4 Transcription Factor, Th17 Cells, Th2 Cells
Added January 20, 2015
0 Communities
2 Members
0 Resources
12 MeSH Terms
Small molecule-directed immunotherapy against recurrent infection by Mycobacterium tuberculosis.
Bhattacharya D, Dwivedi VP, Maiga M, Maiga M, Van Kaer L, Bishai WR, Das G
(2014) J Biol Chem 289: 16508-15
MeSH Terms: Animals, Flow Cytometry, Immunotherapy, Mice, Mice, Inbred BALB C, Mycobacterium tuberculosis, Th1 Cells, Th2 Cells, Tuberculosis
Added January 20, 2015
0 Communities
1 Members
0 Resources
9 MeSH Terms
STAT4 and T-bet are required for the plasticity of IFN-γ expression across Th2 ontogeny and influence changes in Ifng promoter DNA methylation.
Williams CL, Schilling MM, Cho SH, Lee K, Wei M, Aditi , Boothby M
(2013) J Immunol 191: 678-87
MeSH Terms: Animals, Cell Differentiation, Cells, Cultured, CpG Islands, DNA Methylation, Immunologic Memory, Interferon-gamma, Interleukin-4, Lymphocyte Activation, Mice, Mice, Inbred BALB C, Mice, Knockout, Mice, Nude, Promoter Regions, Genetic, STAT4 Transcription Factor, T-Box Domain Proteins, Th1 Cells, Th2 Cells
Added March 7, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms