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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 24

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Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity.
Hargrove TY, Garvey EP, Hoekstra WJ, Yates CM, Wawrzak Z, Rachakonda G, Villalta F, Lepesheva GI
(2017) Antimicrob Agents Chemother 61:
MeSH Terms: Antifungal Agents, Aspergillus fumigatus, Candida albicans, Drugs, Investigational, Fluconazole, Ketoconazole, Microbial Sensitivity Tests, Pyridines, Sterol 14-Demethylase, Tetrazoles, Triazoles, Voriconazole
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Response by Hubers and Brown to Letter Regarding Article, "Combined Angiotensin Receptor Antagonism and Neprilysin Inhibition".
Hubers SA, Brown NJ
(2016) Circulation 134: e11-2
MeSH Terms: Aminobutyrates, Angiotensin Receptor Antagonists, Angiotensin-Converting Enzyme Inhibitors, Heart Failure, Humans, Neprilysin, Receptors, Angiotensin, Tetrazoles
Added April 6, 2017
0 Communities
1 Members
0 Resources
8 MeSH Terms
Combined Angiotensin Receptor Antagonism and Neprilysin Inhibition.
Hubers SA, Brown NJ
(2016) Circulation 133: 1115-24
MeSH Terms: Abnormalities, Drug-Induced, Aminobutyrates, Angioedema, Angiotensin Receptor Antagonists, Biphenyl Compounds, Bradykinin, Contraindications, Drug Combinations, Drug Costs, Drug Synergism, Enalapril, Enzyme Inhibitors, Female, Follow-Up Studies, Heart Failure, Humans, Hyperkalemia, Hypertension, Kidney, Multicenter Studies as Topic, Natriuretic Peptides, Neprilysin, Pregnancy, Prodrugs, Prospective Studies, Pyridines, Randomized Controlled Trials as Topic, Stroke Volume, Tetrazoles, Thiazepines, Valsartan
Added April 6, 2017
0 Communities
1 Members
0 Resources
31 MeSH Terms
Clinical Candidate VT-1161's Antiparasitic Effect In Vitro, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme CYP51 from Trypanosoma cruzi.
Hoekstra WJ, Hargrove TY, Wawrzak Z, da Gama Jaen Batista D, da Silva CF, Nefertiti AS, Rachakonda G, Schotzinger RJ, Villalta F, Soeiro Mde N, Lepesheva GI
(2016) Antimicrob Agents Chemother 60: 1058-66
MeSH Terms: 14-alpha Demethylase Inhibitors, Animals, Chagas Disease, Crystallography, X-Ray, Disease Models, Animal, Female, Heme, Mice, Models, Molecular, Protein Conformation, Pyridines, Sterol 14-Demethylase, Tetrazoles, Trypanocidal Agents, Trypanosoma cruzi
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Proteinuria Increases Plasma Phosphate by Altering Its Tubular Handling.
de Seigneux S, Courbebaisse M, Rutkowski JM, Wilhelm-Bals A, Metzger M, Khodo SN, Hasler U, Chehade H, Dizin E, Daryadel A, Stengel B, NephroTest Study Group, Girardin E, Prié D, Wagner CA, Scherer PE, Martin PY, Houillier P, Feraille E
(2015) J Am Soc Nephrol 26: 1608-18
MeSH Terms: Adult, Albuminuria, Analysis of Variance, Animals, Benzimidazoles, Blotting, Western, Child, Disease Models, Animal, Fibroblast Growth Factors, Humans, Kidney Tubules, Proximal, Male, Mice, Mice, Transgenic, Nephrotic Syndrome, Parathyroid Hormone, Phosphates, Prospective Studies, Proteinuria, Rats, Rats, Wistar, Sensitivity and Specificity, Sodium-Phosphate Cotransporter Proteins, Type IIa, Tetrazoles, Urinalysis
Added December 26, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Visit-to-visit variability in blood pressure and kidney and cardiovascular outcomes in patients with type 2 diabetes and nephropathy: a post hoc analysis from the RENAAL study and the Irbesartan Diabetic Nephropathy Trial.
McMullan CJ, Lambers Heerspink HJ, Parving HH, Dwyer JP, Forman JP, de Zeeuw D
(2014) Am J Kidney Dis 64: 714-22
MeSH Terms: Aged, Angiotensin II Type 1 Receptor Blockers, Biphenyl Compounds, Blood Pressure, Cardiovascular Diseases, Cohort Studies, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Double-Blind Method, Female, Follow-Up Studies, Humans, Irbesartan, Kidney, Male, Middle Aged, Office Visits, Prospective Studies, Tetrazoles, Treatment Outcome
Added October 28, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Estimated GFR decline as a surrogate end point for kidney failure: a post hoc analysis from the Reduction of End Points in Non-Insulin-Dependent Diabetes With the Angiotensin II Antagonist Losartan (RENAAL) study and Irbesartan Diabetic Nephropathy Trial (IDNT).
Lambers Heerspink HJ, Weldegiorgis M, Inker LA, Gansevoort R, Parving HH, Dwyer JP, Mondal H, Coresh J, Greene T, Levey AS, de Zeeuw D
(2014) Am J Kidney Dis 63: 244-50
MeSH Terms: Aged, Angiotensin II Type 1 Receptor Blockers, Biomarkers, Biphenyl Compounds, Diabetes Mellitus, Type 2, Double-Blind Method, Female, Glomerular Filtration Rate, Humans, Irbesartan, Kidney Failure, Chronic, Losartan, Male, Middle Aged, Tetrazoles
Added October 28, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Impaired systolic function by strain imaging in heart failure with preserved ejection fraction.
Kraigher-Krainer E, Shah AM, Gupta DK, Santos A, Claggett B, Pieske B, Zile MR, Voors AA, Lefkowitz MP, Packer M, McMurray JJ, Solomon SD, PARAMOUNT Investigators
(2014) J Am Coll Cardiol 63: 447-56
MeSH Terms: Aged, Aged, 80 and over, Aminobutyrates, Angiotensin II Type 1 Receptor Blockers, Drug Combinations, Echocardiography, Doppler, Color, Female, Follow-Up Studies, Heart Failure, Heart Ventricles, Humans, Male, Middle Aged, Neprilysin, Prognosis, Prospective Studies, Stroke Volume, Tetrazoles, Valine, Valsartan, Ventricular Function, Left
Added February 28, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ.
Yamanaka K, Dorjsuren D, Eoff RL, Egli M, Maloney DJ, Jadhav A, Simeonov A, Lloyd RS
(2012) PLoS One 7: e45032
MeSH Terms: Acrolein, Benzimidazoles, Biphenyl Compounds, Cell Line, Transformed, Cell Survival, DNA, DNA Adducts, DNA Damage, DNA Repair, DNA-Directed DNA Polymerase, Deoxyguanosine, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Enzyme Inhibitors, Humans, Indoles, Nucleic Acid Synthesis Inhibitors, Small Molecule Libraries, Terpenes, Tetrazoles, Ultraviolet Rays
Added May 27, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
Comparative effects of angiotensin receptor blockade and ACE inhibition on the fibrinolytic and inflammatory responses to cardiopulmonary bypass.
Billings FT, Balaguer JM, C Y, Wright P, Petracek MR, Byrne JG, Brown NJ, Pretorius M
(2012) Clin Pharmacol Ther 91: 1065-73
MeSH Terms: Aged, Angiotensin II Type 1 Receptor Blockers, Angiotensin-Converting Enzyme Inhibitors, Benzimidazoles, Blood Transfusion, Bradykinin, Cardiopulmonary Bypass, Endpoint Determination, Female, Fibrinolysis, Hematocrit, Hospital Mortality, Humans, Inflammation, Interleukins, Length of Stay, Male, Middle Aged, Monitoring, Intraoperative, Perioperative Care, Postoperative Complications, Ramipril, Tetrazoles, Treatment Outcome
Added December 10, 2013
0 Communities
2 Members
0 Resources
24 MeSH Terms