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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 12

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A small molecule agonist THIQ as a novel pharmacoperone for intracellularly retained melanocortin-4 receptor mutants.
Huang H, Tao YX
(2014) Int J Biol Sci 10: 817-24
MeSH Terms: Flow Cytometry, HEK293 Cells, Humans, Microscopy, Confocal, Receptor, Melanocortin, Type 4, Tetrahydroisoquinolines, Triazoles
Added January 29, 2016
0 Communities
1 Members
0 Resources
7 MeSH Terms
Dual targeting of EWS-FLI1 activity and the associated DNA damage response with trabectedin and SN38 synergistically inhibits Ewing sarcoma cell growth.
Grohar PJ, Segars LE, Yeung C, Pommier Y, D'Incalci M, Mendoza A, Helman LJ
(2014) Clin Cancer Res 20: 1190-203
MeSH Terms: Animals, Antineoplastic Agents, Camptothecin, Cell Line, Tumor, DNA Breaks, Double-Stranded, DNA Damage, Dioxoles, Disease Models, Animal, Doxorubicin, Drug Resistance, Neoplasm, Drug Synergism, Exodeoxyribonucleases, Female, Gene Expression Regulation, Neoplastic, Gene Silencing, Humans, Irinotecan, Mice, Oncogene Proteins, Fusion, Phenotype, Proto-Oncogene Protein c-fli-1, RNA Interference, RNA, Small Interfering, RNA-Binding Protein EWS, RecQ Helicases, Sarcoma, Ewing, Tetrahydroisoquinolines, Trabectedin, Werner Syndrome Helicase, Xenograft Model Antitumor Assays
Added March 5, 2014
0 Communities
1 Members
0 Resources
30 MeSH Terms
Prospects and challenges for the development of new therapies for Ewing sarcoma.
Grohar PJ, Helman LJ
(2013) Pharmacol Ther 137: 216-24
MeSH Terms: Antineoplastic Agents, Bone Neoplasms, Camptothecin, Clinical Trials as Topic, Dioxoles, Epigenesis, Genetic, Humans, Molecular Targeted Therapy, Poly(ADP-ribose) Polymerase Inhibitors, Sarcoma, Ewing, Somatomedins, Tetrahydroisoquinolines, Trabectedin
Added September 3, 2013
0 Communities
2 Members
0 Resources
13 MeSH Terms
Kappa opioid receptor signaling in the basolateral amygdala regulates conditioned fear and anxiety in rats.
Knoll AT, Muschamp JW, Sillivan SE, Ferguson D, Dietz DM, Meloni EG, Carroll FI, Nestler EJ, Konradi C, Carlezon WA
(2011) Biol Psychiatry 70: 425-33
MeSH Terms: Amygdala, Animals, Anxiety, Conditioning, Psychological, Corpus Striatum, Disease Models, Animal, Dynorphins, Extinction, Psychological, Fear, Gene Expression Regulation, Hippocampus, Male, Maze Learning, Microinjections, Piperidines, Rats, Receptors, Opioid, kappa, Reflex, Startle, Signal Transduction, Tetrahydroisoquinolines
Added May 27, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Ecteinascidin 743 interferes with the activity of EWS-FLI1 in Ewing sarcoma cells.
Grohar PJ, Griffin LB, Yeung C, Chen QR, Pommier Y, Khanna C, Khan J, Helman LJ
(2011) Neoplasia 13: 145-53
MeSH Terms: Antineoplastic Agents, Alkylating, Bone Neoplasms, Cell Line, Tumor, Child, DAX-1 Orphan Nuclear Receptor, Dioxoles, Europe, Gene Expression Regulation, Neoplastic, Humans, Oncogene Proteins, Fusion, Promoter Regions, Genetic, Proto-Oncogene Protein c-fli-1, RNA-Binding Protein EWS, RNA-Binding Protein FUS, Sarcoma, Sarcoma, Ewing, Tetrahydroisoquinolines, Trabectedin, Transcription Factor CHOP
Added September 3, 2013
0 Communities
2 Members
0 Resources
19 MeSH Terms
Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: results of a randomized phase II study of two different schedules.
Demetri GD, Chawla SP, von Mehren M, Ritch P, Baker LH, Blay JY, Hande KR, Keohan ML, Samuels BL, Schuetze S, Lebedinsky C, Elsayed YA, Izquierdo MA, Gómez J, Park YC, Le Cesne A
(2009) J Clin Oncol 27: 4188-96
MeSH Terms: Adult, Aged, Aged, 80 and over, Anthracyclines, Antibiotics, Antineoplastic, Antineoplastic Agents, Alkylating, Australia, Dioxoles, Disease-Free Survival, Drug Administration Schedule, Drug Resistance, Neoplasm, Europe, Female, Humans, Ifosfamide, Infusions, Intravenous, Kaplan-Meier Estimate, Leiomyosarcoma, Liposarcoma, Male, Middle Aged, Neoplasm Staging, North America, Proportional Hazards Models, Risk Assessment, Tetrahydroisoquinolines, Time Factors, Trabectedin, Treatment Failure, Young Adult
Added March 20, 2014
0 Communities
1 Members
0 Resources
30 MeSH Terms
Single-agent trabectedin as second-line therapy of persistent or recurrent endometrial cancer: results of a multicenter phase II study.
McMeekin DS, Lisyanskaya A, Crispens M, Oza AM, Braly P, Doering D, Bayever E, Michiels B, Markman M
(2009) Gynecol Oncol 114: 288-92
MeSH Terms: Adult, Aged, Aged, 80 and over, Antineoplastic Agents, Alkylating, Dioxoles, Disease-Free Survival, Endometrial Neoplasms, Female, Humans, Infusions, Intravenous, Middle Aged, Neoplasm Recurrence, Local, Tetrahydroisoquinolines, Trabectedin, Young Adult
Added March 10, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
A randomized trial of a 6-week course of celecoxib on proteinuria in diabetic kidney disease.
Sinsakul M, Sika M, Rodby R, Middleton J, Shyr Y, Chen H, Han E, Lehrich R, Clyne S, Schulman G, Harris R, Lewis J
(2007) Am J Kidney Dis 50: 946-51
MeSH Terms: Aged, Angiotensin-Converting Enzyme Inhibitors, Aspirin, Celecoxib, Creatinine, Cross-Over Studies, Cyclooxygenase Inhibitors, Diabetic Nephropathies, Dose-Response Relationship, Drug, Double-Blind Method, Drug Therapy, Combination, Humans, Middle Aged, Models, Statistical, Pilot Projects, Proteinuria, Pyrazoles, Quinapril, Sulfonamides, Tetrahydroisoquinolines
Added March 25, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Inhibition of aminopeptidase P potentiates wheal response to bradykinin in angiotensin-converting enzyme inhibitor-treated humans.
Kim KS, Kumar S, Simmons WH, Brown NJ
(2000) J Pharmacol Exp Ther 292: 295-8
MeSH Terms: Adult, Aminopeptidases, Angiotensin-Converting Enzyme Inhibitors, Bradykinin, Dose-Response Relationship, Drug, Drug Synergism, Female, Humans, Inflammation, Isoquinolines, Male, Peptides, Protease Inhibitors, Quinapril, Tetrahydroisoquinolines, Time Factors, Urticaria
Added December 10, 2013
0 Communities
1 Members
0 Resources
17 MeSH Terms
Comparative effect of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor antagonism on plasma fibrinolytic balance in humans.
Brown NJ, Agirbasli M, Vaughan DE
(1999) Hypertension 34: 285-90
MeSH Terms: Adult, Aldosterone, Angiotensin II, Angiotensin Receptor Antagonists, Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Blood Pressure, Data Interpretation, Statistical, Diet, Sodium-Restricted, Female, Fibrinolysis, Heart Rate, Humans, Isoquinolines, Losartan, Male, Plasminogen Activator Inhibitor 1, Quinapril, Renin, Renin-Angiotensin System, Tetrahydroisoquinolines, Tissue Plasminogen Activator
Added December 10, 2013
0 Communities
1 Members
0 Resources
22 MeSH Terms