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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 2 of 2

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Channel Activity of Cardiac Ryanodine Receptors (RyR2) Determines Potency and Efficacy of Flecainide and R-Propafenone against Arrhythmogenic Calcium Waves in Ventricular Cardiomyocytes.
Savio-Galimberti E, Knollmann BC
(2015) PLoS One 10: e0131179
MeSH Terms: Animals, Arrhythmias, Cardiac, Caffeine, Calcium, Calcium Signaling, Calsequestrin, Cell Membrane Permeability, Flecainide, Heart Ventricles, Humans, Inhibitory Concentration 50, Male, Mice, Inbred C57BL, Myocytes, Cardiac, Propafenone, Rabbits, Ryanodine Receptor Calcium Release Channel, Tetracaine
Added February 22, 2016
0 Communities
1 Members
0 Resources
18 MeSH Terms
Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass.
Hilliard FA, Steele DS, Laver D, Yang Z, Le Marchand SJ, Chopra N, Piston DW, Huke S, Knollmann BC
(2010) J Mol Cell Cardiol 48: 293-301
MeSH Terms: Animals, Arrhythmias, Cardiac, Calcium, Calcium Channel Blockers, Calcium Signaling, Calcium-Binding Proteins, Cell Membrane Permeability, Flecainide, Humans, Mice, Myocytes, Cardiac, Rats, Ryanodine Receptor Calcium Release Channel, Sarcoplasmic Reticulum, Tetracaine
Added December 6, 2012
0 Communities
2 Members
0 Resources
15 MeSH Terms