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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 20

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RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide Action in CPVT.
Kryshtal DO, Blackwell DJ, Egly CL, Smith AN, Batiste SM, Johnston JN, Laver DR, Knollmann BC
(2021) Circ Res 128: 321-331
MeSH Terms: Action Potentials, Animals, Anti-Arrhythmia Agents, Calcium Channel Blockers, Calcium Signaling, Calsequestrin, Disease Models, Animal, Female, Flecainide, HEK293 Cells, Heart Rate, Humans, Male, Mice, Knockout, Myocytes, Cardiac, Phosphorylation, Ryanodine Receptor Calcium Release Channel, Sarcoplasmic Reticulum, Sheep, Domestic, Tachycardia, Ventricular, Voltage-Gated Sodium Channel Blockers
Added December 21, 2020
1 Communities
0 Members
0 Resources
21 MeSH Terms
Calmodulin Mutations Associated with Heart Arrhythmia: A Status Report.
Chazin WJ, Johnson CN
(2020) Int J Mol Sci 21:
MeSH Terms: Arrhythmias, Cardiac, Calcium Signaling, Calmodulin, Humans, Ion Channels, Long QT Syndrome, Myocytes, Cardiac, Ryanodine Receptor Calcium Release Channel, Tachycardia, Ventricular
Added March 11, 2020
0 Communities
1 Members
0 Resources
9 MeSH Terms
Atropine-induced sinus tachycardia protects against exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia.
Kannankeril PJ, Shoemaker MB, Gayle KA, Fountain D, Roden DM, Knollmann BC
(2020) Europace 22: 643-648
MeSH Terms: Animals, Atropine, Humans, Mice, Prospective Studies, Ryanodine Receptor Calcium Release Channel, Tachycardia, Sinus, Tachycardia, Ventricular
Added March 24, 2020
0 Communities
1 Members
0 Resources
8 MeSH Terms
Calmodulin Mutants Linked to Catecholaminergic Polymorphic Ventricular Tachycardia Fail to Inhibit Human RyR2 Channels.
Walweel K, Gomez-Hurtado N, Oo YW, Beard NA, Dos Remedios C, Johnson CN, Chazin WJ, van Helden DF, Knollmann BC, Laver DR
(2017) J Am Coll Cardiol 70: 115-117
MeSH Terms: Calmodulin, Heart Ventricles, Humans, In Vitro Techniques, Mutation, Phosphorylation, Ryanodine Receptor Calcium Release Channel, Tachycardia, Ventricular
Added March 24, 2018
0 Communities
1 Members
0 Resources
8 MeSH Terms
Efficacy of Flecainide in the Treatment of Catecholaminergic Polymorphic Ventricular Tachycardia: A Randomized Clinical Trial.
Kannankeril PJ, Moore JP, Cerrone M, Priori SG, Kertesz NJ, Ro PS, Batra AS, Kaufman ES, Fairbrother DL, Saarel EV, Etheridge SP, Kanter RJ, Carboni MP, Dzurik MV, Fountain D, Chen H, Ely EW, Roden DM, Knollmann BC
(2017) JAMA Cardiol 2: 759-766
MeSH Terms: Adolescent, Adrenergic beta-Antagonists, Anti-Arrhythmia Agents, Cross-Over Studies, Death, Sudden, Cardiac, Defibrillators, Implantable, Drug Therapy, Combination, Exercise, Exercise Test, Female, Flecainide, Humans, Male, Maximum Tolerated Dose, Single-Blind Method, Tachycardia, Ventricular, Young Adult
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks.
Gomez-Hurtado N, Boczek NJ, Kryshtal DO, Johnson CN, Sun J, Nitu FR, Cornea RL, Chazin WJ, Calvert ML, Tester DJ, Ackerman MJ, Knollmann BC
(2016) Circ Arrhythm Electrophysiol 9:
MeSH Terms: Action Potentials, Adult, Animals, Calmodulin, DNA Mutational Analysis, Electrocardiography, Exercise Test, Female, Genotype, Humans, Long QT Syndrome, Male, Mice, Phenotype, Ryanodine, Tachycardia, Ventricular
Added April 18, 2017
0 Communities
1 Members
0 Resources
16 MeSH Terms
Novel calmodulin mutations associated with congenital arrhythmia susceptibility.
Makita N, Yagihara N, Crotti L, Johnson CN, Beckmann BM, Roh MS, Shigemizu D, Lichtner P, Ishikawa T, Aiba T, Homfray T, Behr ER, Klug D, Denjoy I, Mastantuono E, Theisen D, Tsunoda T, Satake W, Toda T, Nakagawa H, Tsuji Y, Tsuchiya T, Yamamoto H, Miyamoto Y, Endo N, Kimura A, Ozaki K, Motomura H, Suda K, Tanaka T, Schwartz PJ, Meitinger T, Kääb S, Guicheney P, Shimizu W, Bhuiyan ZA, Watanabe H, Chazin WJ, George AL
(2014) Circ Cardiovasc Genet 7: 466-74
MeSH Terms: Adrenergic beta-Antagonists, Adult, Age of Onset, Amino Acid Sequence, Calcium, Calmodulin, Child, Child, Preschool, Electrocardiography, Female, Genetic Predisposition to Disease, High-Throughput Nucleotide Sequencing, Humans, Infant, Long QT Syndrome, Male, Molecular Sequence Data, Mutation, Missense, Pedigree, Protein Binding, Sequence Analysis, DNA, Tachycardia, Ventricular
Added January 20, 2015
0 Communities
1 Members
0 Resources
22 MeSH Terms
Elevation of plasma milrinone concentrations in stage D heart failure associated with renal dysfunction.
Cox ZL, Calcutt MW, Morrison TB, Akers WS, Davis MB, Lenihan DJ
(2013) J Cardiovasc Pharmacol Ther 18: 433-8
MeSH Terms: Adult, Aged, Cardiac Catheterization, Cardiotonic Agents, Creatinine, Defibrillators, Implantable, Female, Heart Failure, Hemodynamics, Humans, Kidney Diseases, Male, Middle Aged, Milrinone, Renal Dialysis, Retrospective Studies, Severity of Illness Index, Tachycardia, Ventricular
Added May 27, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
Myofilament calcium de-sensitization and contractile uncoupling prevent pause-triggered ventricular tachycardia in mouse hearts with chronic myocardial infarction.
Venkataraman R, Baldo MP, Hwang HS, Veltri T, Pinto JR, Baudenbacher FJ, Knollmann BC
(2013) J Mol Cell Cardiol 60: 8-15
MeSH Terms: Animals, Calcium, Chronic Disease, Disease Models, Animal, Heterocyclic Compounds, 4 or More Rings, Male, Mice, Myocardial Contraction, Myocardial Infarction, Myocardium, Myofibrils, Tachycardia, Ventricular
Added February 12, 2015
0 Communities
1 Members
0 Resources
12 MeSH Terms
Triadin regulates cardiac muscle couplon structure and microdomain Ca(2+) signalling: a path towards ventricular arrhythmias.
Chopra N, Knollmann BC
(2013) Cardiovasc Res 98: 187-91
MeSH Terms: Animals, Calcium Channels, L-Type, Calcium Signaling, Calsequestrin, Carrier Proteins, Excitation Contraction Coupling, Humans, Membrane Microdomains, Muscle Proteins, Myocytes, Cardiac, Ryanodine Receptor Calcium Release Channel, Sarcoplasmic Reticulum, Tachycardia, Ventricular
Added February 12, 2015
0 Communities
1 Members
0 Resources
13 MeSH Terms