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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 113

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Tacrolimus- and sirolimus-induced human β cell dysfunction is reversible and preventable.
Dai C, Walker JT, Shostak A, Padgett A, Spears E, Wisniewski S, Poffenberger G, Aramandla R, Dean ED, Prasad N, Levy SE, Greiner DL, Shultz LD, Bottino R, Powers AC
(2020) JCI Insight 5:
MeSH Terms: Animals, Calcineurin, Diabetes Mellitus, Graft Rejection, Humans, Immunosuppressive Agents, Insulin, Insulin-Secreting Cells, Islets of Langerhans, Islets of Langerhans Transplantation, Male, Mice, Signal Transduction, Sirolimus, TOR Serine-Threonine Kinases, Tacrolimus
Added March 29, 2020
0 Communities
1 Members
0 Resources
16 MeSH Terms
Cyclin G1 and TASCC regulate kidney epithelial cell G-M arrest and fibrotic maladaptive repair.
Canaud G, Brooks CR, Kishi S, Taguchi K, Nishimura K, Magassa S, Scott A, Hsiao LL, Ichimura T, Terzi F, Yang L, Bonventre JV
(2019) Sci Transl Med 11:
MeSH Terms: Animals, Autophagy, Cell Compartmentation, Cell Cycle Checkpoints, Cell Dedifferentiation, Cyclin G1, Disease Models, Animal, Disease Progression, Epithelial Cells, Fibrosis, Humans, Kidney, Kidney Tubules, Proximal, LLC-PK1 Cells, Male, Mice, Renal Insufficiency, Chronic, Swine, TOR Serine-Threonine Kinases, Wound Healing
Added March 14, 2019
0 Communities
1 Members
0 Resources
20 MeSH Terms
The TLR4 Agonist Monophosphoryl Lipid A Drives Broad Resistance to Infection via Dynamic Reprogramming of Macrophage Metabolism.
Fensterheim BA, Young JD, Luan L, Kleinbard RR, Stothers CL, Patil NK, McAtee-Pereira AG, Guo Y, Trenary I, Hernandez A, Fults JB, Williams DL, Sherwood ER, Bohannon JK
(2018) J Immunol 200: 3777-3789
MeSH Terms: Adenosine Triphosphate, Animals, Candida albicans, Candidiasis, Glycolysis, Lipid A, Macrophages, Male, Mice, Mice, Inbred C57BL, Myeloid Differentiation Factor 88, Signal Transduction, Staphylococcal Infections, Staphylococcus aureus, TOR Serine-Threonine Kinases, Toll-Like Receptor 4
Added March 28, 2019
0 Communities
3 Members
0 Resources
16 MeSH Terms
Heterozygous loss of TSC2 alters p53 signaling and human stem cell reprogramming.
Armstrong LC, Westlake G, Snow JP, Cawthon B, Armour E, Bowman AB, Ess KC
(2017) Hum Mol Genet 26: 4629-4641
MeSH Terms: Adolescent, Adult, Alleles, Cellular Reprogramming, Child, Child, Preschool, Female, Fibroblasts, Genes, p53, Heterozygote, Humans, Induced Pluripotent Stem Cells, Infant, Loss of Heterozygosity, Male, Mutation, RNA, Small Interfering, Signal Transduction, TOR Serine-Threonine Kinases, Tuberous Sclerosis, Tuberous Sclerosis Complex 1 Protein, Tuberous Sclerosis Complex 2 Protein, Tumor Suppressor Protein p53, Tumor Suppressor Proteins
Added April 11, 2018
0 Communities
1 Members
0 Resources
24 MeSH Terms
The glucagon-like peptide-1 receptor in the ventromedial hypothalamus reduces short-term food intake in male mice by regulating nutrient sensor activity.
Burmeister MA, Brown JD, Ayala JE, Stoffers DA, Sandoval DA, Seeley RJ, Ayala JE
(2017) Am J Physiol Endocrinol Metab 313: E651-E662
MeSH Terms: Acetyl-CoA Carboxylase, Adenylate Kinase, Animals, Body Composition, CHO Cells, Cricetulus, Dose-Response Relationship, Drug, Eating, Exenatide, Food, Glucagon-Like Peptide-1 Receptor, Glycolysis, Homeostasis, Male, Mice, Mice, Inbred C57BL, Peptides, Sensation, TOR Serine-Threonine Kinases, Venoms, Ventromedial Hypothalamic Nucleus
Added October 23, 2017
0 Communities
1 Members
0 Resources
21 MeSH Terms
Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets.
Sinagoga KL, Stone WJ, Schiesser JV, Schweitzer JI, Sampson L, Zheng Y, Wells JM
(2017) Development 144: 2402-2414
MeSH Terms: Animals, Animals, Newborn, Cell Aggregation, Islets of Langerhans, Mechanistic Target of Rapamycin Complex 1, Mechanistic Target of Rapamycin Complex 2, Mice, Models, Biological, Morphogenesis, Multiprotein Complexes, Mutation, Signal Transduction, TOR Serine-Threonine Kinases
Added February 6, 2018
0 Communities
1 Members
0 Resources
13 MeSH Terms
In silico evaluation of DNA Damage Inducible Transcript 4 gene (DDIT4) as prognostic biomarker in several malignancies.
Pinto JA, Rolfo C, Raez LE, Prado A, Araujo JM, Bravo L, Fajardo W, Morante ZD, Aguilar A, Neciosup SP, Mas LA, Bretel D, Balko JM, Gomez HL
(2017) Sci Rep 7: 1526
MeSH Terms: Biomarkers, Tumor, Computer Simulation, DNA Damage, Databases as Topic, Humans, Neoplasms, Phosphatidylinositol 3-Kinases, Prognosis, Signal Transduction, Sirolimus, Survival Analysis, TOR Serine-Threonine Kinases, Transcription Factors, Treatment Outcome
Added March 14, 2018
0 Communities
1 Members
0 Resources
14 MeSH Terms
Strategies to overcome therapeutic resistance in renal cell carcinoma.
Siska PJ, Beckermann KE, Rathmell WK, Haake SM
(2017) Urol Oncol 35: 102-110
MeSH Terms: Angiogenesis Inhibitors, Antineoplastic Agents, Carcinoma, Renal Cell, Clinical Trials as Topic, Costimulatory and Inhibitory T-Cell Receptors, Cytotoxicity, Immunologic, Disease Progression, Disease-Free Survival, Drug Resistance, Neoplasm, Humans, Immunotherapy, Kidney, Kidney Neoplasms, Neoplasm Recurrence, Local, Neovascularization, Pathologic, Nephrectomy, Protein Kinase Inhibitors, Receptors, Vascular Endothelial Growth Factor, Signal Transduction, TOR Serine-Threonine Kinases
Added April 18, 2017
1 Communities
2 Members
0 Resources
20 MeSH Terms
mTORC1 and mTORC2 in cancer and the tumor microenvironment.
Kim LC, Cook RS, Chen J
(2017) Oncogene 36: 2191-2201
MeSH Terms: Animals, Humans, Mechanistic Target of Rapamycin Complex 1, Mechanistic Target of Rapamycin Complex 2, Multiprotein Complexes, Neoplasms, TOR Serine-Threonine Kinases, Tumor Microenvironment
Added March 29, 2017
1 Communities
2 Members
0 Resources
8 MeSH Terms
Macrophage Apoptosis and Efferocytosis in the Pathogenesis of Atherosclerosis.
Linton MF, Babaev VR, Huang J, Linton EF, Tao H, Yancey PG
(2016) Circ J 80: 2259-2268
MeSH Terms: Animals, Atherosclerosis, Endoplasmic Reticulum Stress, Humans, I-kappa B Kinase, Isoenzymes, Macrophages, Mechanistic Target of Rapamycin Complex 2, Mitogen-Activated Protein Kinase 8, Multiprotein Complexes, Proto-Oncogene Proteins c-akt, Signal Transduction, TOR Serine-Threonine Kinases, Unfolded Protein Response
Added April 10, 2018
0 Communities
1 Members
0 Resources
MeSH Terms