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Results: 1 to 10 of 12

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Gβγ directly modulates vesicle fusion by competing with synaptotagmin for binding to neuronal SNARE proteins embedded in membranes.
Zurawski Z, Page B, Chicka MC, Brindley RL, Wells CA, Preininger AM, Hyde K, Gilbert JA, Cruz-Rodriguez O, Currie KPM, Chapman ER, Alford S, Hamm HE
(2017) J Biol Chem 292: 12165-12177
MeSH Terms: Animals, Binding, Competitive, Calcium Signaling, Cattle, Cell Line, GTP-Binding Protein beta Subunits, GTP-Binding Protein gamma Subunits, Humans, Lipid Bilayers, Liposomes, Membrane Fusion, Models, Molecular, Mutation, Nerve Tissue Proteins, Peptide Fragments, Protein Conformation, Protein Interaction Domains and Motifs, Protein Multimerization, Rats, Recombinant Fusion Proteins, Recombinant Proteins, Synaptosomal-Associated Protein 25, Synaptotagmin I, Syntaxin 1
Added July 12, 2017
0 Communities
2 Members
0 Resources
24 MeSH Terms
TSH elevations as the first laboratory evidence for pseudohypoparathyroidism type Ib (PHP-Ib).
Molinaro A, Tiosano D, Takatani R, Chrysis D, Russell W, Koscielniak N, Kottler ML, Agretti P, De Marco G, Ahtiainen P, Christov M, Mäkitie O, Tonacchera M, Jüppner H
(2015) J Bone Miner Res 30: 906-12
MeSH Terms: Adult, Child, Preschool, Chromosomes, Human, Pair 20, Epigenesis, Genetic, Exons, Female, Humans, Infant, Infant, Newborn, Male, Pseudohypoparathyroidism, Syntaxin 16, Thyrotropin, Young Adult
Added May 5, 2016
0 Communities
1 Members
0 Resources
14 MeSH Terms
Gβγ inhibits exocytosis via interaction with critical residues on soluble N-ethylmaleimide-sensitive factor attachment protein-25.
Wells CA, Zurawski Z, Betke KM, Yim YY, Hyde K, Rodriguez S, Alford S, Hamm HE
(2012) Mol Pharmacol 82: 1136-49
MeSH Terms: Alanine, Animals, Binding Sites, Botulinum Toxins, Calcium, Cell Line, Exocytosis, GTP-Binding Protein beta Subunits, GTP-Binding Protein gamma Subunits, Lampreys, Mutation, Neurons, Peptides, Protein Binding, Protein Interaction Domains and Motifs, Recombinant Fusion Proteins, SNARE Proteins, Sf9 Cells, Spodoptera, Synaptosomal-Associated Protein 25, Synaptotagmin I, Syntaxin 1
Added December 10, 2013
0 Communities
1 Members
0 Resources
22 MeSH Terms
Dopamine transporter/syntaxin 1A interactions regulate transporter channel activity and dopaminergic synaptic transmission.
Carvelli L, Blakely RD, DeFelice LJ
(2008) Proc Natl Acad Sci U S A 105: 14192-7
MeSH Terms: Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Dopamine, Dopamine Plasma Membrane Transport Proteins, Electrophysiology, Genes, Reporter, Patch-Clamp Techniques, Protein Binding, Recombinant Fusion Proteins, Swimming, Synaptic Transmission, Syntaxin 1
Added July 10, 2013
1 Communities
1 Members
0 Resources
13 MeSH Terms
Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux.
Binda F, Dipace C, Bowton E, Robertson SD, Lute BJ, Fog JU, Zhang M, Sen N, Colbran RJ, Gnegy ME, Gether U, Javitch JA, Erreger K, Galli A
(2008) Mol Pharmacol 74: 1101-8
MeSH Terms: Amino Acid Sequence, Amphetamine, Animals, Cell Line, Cell Membrane, Cells, Cultured, Corpus Striatum, Dopamine, Dopamine Plasma Membrane Transport Proteins, Glutathione Transferase, Humans, Kidney, Mesencephalon, Mice, Mice, Transgenic, Molecular Sequence Data, Neurons, Recombinant Fusion Proteins, Synaptosomes, Syntaxin 1, Transfection
Added December 10, 2013
0 Communities
1 Members
0 Resources
21 MeSH Terms
Gbetagamma interferes with Ca2+-dependent binding of synaptotagmin to the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex.
Yoon EJ, Gerachshenko T, Spiegelberg BD, Alford S, Hamm HE
(2007) Mol Pharmacol 72: 1210-9
MeSH Terms: Animals, Calcium, Cattle, Exocytosis, GTP-Binding Protein beta Subunits, GTP-Binding Protein gamma Subunits, Lampreys, SNARE Proteins, Serotonin, Spinal Cord, Synapses, Synaptosomal-Associated Protein 25, Synaptotagmin I, Syntaxin 1, Vesicle-Associated Membrane Protein 2
Added December 10, 2013
0 Communities
1 Members
0 Resources
15 MeSH Terms
Calcium-dependent interactions of the human norepinephrine transporter with syntaxin 1A.
Sung U, Blakely RD
(2007) Mol Cell Neurosci 34: 251-60
MeSH Terms: Animals, Calcium, Cells, Cultured, Cerebral Cortex, Cricetinae, Cricetulus, Drug Interactions, Enzyme Activation, Humans, Models, Biological, Neurons, Norepinephrine Plasma Membrane Transport Proteins, Phorbol Esters, Protein Kinase C, Protein Transport, Synaptosomes, Syntaxin 1, Time Factors, Transfection
Added July 10, 2013
1 Communities
1 Members
0 Resources
19 MeSH Terms
Amphetamine induces a calcium/calmodulin-dependent protein kinase II-dependent reduction in norepinephrine transporter surface expression linked to changes in syntaxin 1A/transporter complexes.
Dipace C, Sung U, Binda F, Blakely RD, Galli A
(2007) Mol Pharmacol 71: 230-9
MeSH Terms: Amphetamine, Biotinylation, Calcium, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Calcium-Calmodulin-Dependent Protein Kinases, Cell Line, Cell Membrane, Enzyme Activation, Gene Expression Regulation, Humans, Kinetics, Norepinephrine Plasma Membrane Transport Proteins, Syntaxin 1
Added December 10, 2013
1 Communities
2 Members
0 Resources
13 MeSH Terms
The N-terminus of the norepinephrine transporter regulates the magnitude and selectivity of the transporter-associated leak current.
Binda F, Lute BJ, Dipace C, Blakely RD, Galli A
(2006) Neuropharmacology 50: 354-61
MeSH Terms: Amino Acid Sequence, Analysis of Variance, Animals, Biological Transport, Active, Cell Line, Chlorides, Dose-Response Relationship, Drug, Dose-Response Relationship, Radiation, Electric Stimulation, Humans, Membrane Potentials, Mice, Mutagenesis, Site-Directed, Norepinephrine, Norepinephrine Plasma Membrane Transport Proteins, Patch-Clamp Techniques, Protein Structure, Tertiary, Sodium, Syntaxin 1, Transfection
Added December 10, 2013
1 Communities
2 Members
0 Resources
20 MeSH Terms
A regulated interaction of syntaxin 1A with the antidepressant-sensitive norepinephrine transporter establishes catecholamine clearance capacity.
Sung U, Apparsundaram S, Galli A, Kahlig KM, Savchenko V, Schroeter S, Quick MW, Blakely RD
(2003) J Neurosci 23: 1697-709
MeSH Terms: Animals, Antidepressive Agents, Antigens, Surface, Botulinum Toxins, Brain Chemistry, Catecholamines, Cells, Cultured, Enzyme Activation, Enzyme Activators, Enzyme Inhibitors, Humans, Male, Membrane Proteins, Mice, Mice, Inbred C57BL, Nerve Tissue Proteins, Neurons, Norepinephrine, Norepinephrine Plasma Membrane Transport Proteins, Oligonucleotides, Antisense, Patch-Clamp Techniques, Protein Binding, Protein Structure, Tertiary, Protein Transport, Rats, Recombinant Fusion Proteins, SNARE Proteins, Sequence Deletion, Symporters, Synaptosomes, Syntaxin 1, Vas Deferens, Vesicular Transport Proteins
Added December 10, 2013
1 Communities
2 Members
0 Resources
33 MeSH Terms