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Results: 1 to 10 of 13

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Knockdown of survivin results in inhibition of epithelial to mesenchymal transition in retinal pigment epithelial cells by attenuating the TGFβ pathway.
Zhang P, Zhao G, Ji L, Yin J, Lu L, Li W, Zhou G, Chaum E, Yue J
(2018) Biochem Biophys Res Commun 498: 573-578
MeSH Terms: CRISPR-Cas Systems, Cell Line, Cell Proliferation, Epithelial-Mesenchymal Transition, Humans, Inhibitor of Apoptosis Proteins, Retinal Pigment Epithelium, Signal Transduction, Survivin, Transforming Growth Factor beta, Vitreoretinopathy, Proliferative
Added June 11, 2018
0 Communities
1 Members
0 Resources
11 MeSH Terms
Epithelial PIK3R1 (p85) and TP53 Regulate Survivin Expression during Adaptation to Ileocecal Resection.
Cohran V, Managlia E, Bradford EM, Goretsky T, Li T, Katzman RB, Cheresh P, Brown JB, Hawkins J, Liu SXL, De Plaen IG, Weitkamp JH, Helmrath M, Zhang Z, Barrett TA
(2016) Am J Pathol 186: 1837-1846
MeSH Terms: Adaptation, Physiological, Animals, Blotting, Western, Class Ia Phosphatidylinositol 3-Kinase, Digestive System Surgical Procedures, Disease Models, Animal, Enterocolitis, Necrotizing, Extracellular Matrix Proteins, Gene Expression Regulation, Humans, Immunohistochemistry, Infant, Infant, Newborn, Inhibitor of Apoptosis Proteins, Mice, Mice, Inbred C57BL, Phosphatidylinositol 3-Kinases, Real-Time Polymerase Chain Reaction, Repressor Proteins, Short Bowel Syndrome, Survivin, Tumor Suppressor Protein p53
Added April 16, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer.
Kabisch M, Lorenzo Bermejo J, Dünnebier T, Ying S, Michailidou K, Bolla MK, Wang Q, Dennis J, Shah M, Perkins BJ, Czene K, Darabi H, Eriksson M, Bojesen SE, Nordestgaard BG, Nielsen SF, Flyger H, Lambrechts D, Neven P, Peeters S, Weltens C, Couch FJ, Olson JE, Wang X, Purrington K, Chang-Claude J, Rudolph A, Seibold P, Flesch-Janys D, Peto J, dos-Santos-Silva I, Johnson N, Fletcher O, Nevanlinna H, Muranen TA, Aittomäki K, Blomqvist C, Schmidt MK, Broeks A, Cornelissen S, Hogervorst FB, Li J, Brand JS, Humphreys K, Guénel P, Truong T, Menegaux F, Sanchez M, Burwinkel B, Marmé F, Yang R, Bugert P, González-Neira A, Benitez J, Pilar Zamora M, Arias Perez JI, Cox A, Cross SS, Reed MW, Andrulis IL, Knight JA, Glendon G, Tchatchou S, Sawyer EJ, Tomlinson I, Kerin MJ, Miller N, kConFab Investigators, Australian Ovarian Cancer Study Group, Haiman CA, Schumacher F, Henderson BE, Le Marchand L, Lindblom A, Margolin S, Hooning MJ, Hollestelle A, Kriege M, Koppert LB, Hopper JL, Southey MC, Tsimiklis H, Apicella C, Slettedahl S, Toland AE, Vachon C, Yannoukakos D, Giles GG, Milne RL, McLean C, Fasching PA, Ruebner M, Ekici AB, Beckmann MW, Brenner H, Dieffenbach AK, Arndt V, Stegmaier C, Ashworth A, Orr N, Schoemaker MJ, Swerdlow A, García-Closas M, Figueroa J, Chanock SJ, Lissowska J, Goldberg MS, Labrèche F, Dumont M, Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M, Brauch H, Brüning T, Ko YD, GENICA Network, Radice P, Peterlongo P, Scuvera G, Fortuzzi S, Bogdanova N, Dörk T, Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, Devilee P, Tollenaar RA, Seynaeve C, Van Asperen CJ, Jakubowska A, Lubinski J, Jaworska-Bieniek K, Durda K, Zheng W, Shrubsole MJ, Cai Q, Torres D, Anton-Culver H, Kristensen V, Bacot F, Tessier DC, Vincent D, Luccarini C, Baynes C, Ahmed S, Maranian M, Simard J, Chenevix-Trench G, Hall P, Pharoah PD, Dunning AM, Easton DF, Hamann U
(2015) Carcinogenesis 36: 256-71
MeSH Terms: 3' Untranslated Regions, Aurora Kinase B, Breast Neoplasms, Case-Control Studies, Cell Cycle Proteins, Chromosomal Proteins, Non-Histone, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Inhibitor of Apoptosis Proteins, Polymorphism, Single Nucleotide, Receptors, Estrogen, Risk, Survivin
Added September 28, 2015
0 Communities
2 Members
0 Resources
16 MeSH Terms
Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway.
Zhang B, Zhang B, Chen X, Bae S, Singh K, Washington MK, Datta PK
(2014) Br J Cancer 110: 946-57
MeSH Terms: Animals, Antimetabolites, Antineoplastic, Apoptosis Regulatory Proteins, Cell Cycle Proteins, Cell Line, Tumor, Cell Movement, Cell Proliferation, Cell Survival, Chromones, Colorectal Neoplasms, Drug Resistance, Neoplasm, Enzyme Activation, Enzyme Inhibitors, Fluorouracil, Humans, Inhibitor of Apoptosis Proteins, Mice, Mice, Inbred BALB C, Morpholines, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasm Transplantation, Neovascularization, Pathologic, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Phosphorylation, Proteins, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins c-bcl-2, Repressor Proteins, Retinoblastoma Protein, Smad4 Protein, Survivin, Up-Regulation, Vascular Endothelial Growth Factor A, Wound Healing, Xenograft Model Antitumor Assays
Added April 12, 2016
0 Communities
1 Members
0 Resources
37 MeSH Terms
Survivin mediates renal proximal tubule recovery from AKI.
Chen J, Chen JK, Conway EM, Harris RC
(2013) J Am Soc Nephrol 24: 2023-33
MeSH Terms: Acute Kidney Injury, Animals, Anti-Bacterial Agents, Antimycin A, Cell Line, Inhibitor of Apoptosis Proteins, Kidney Tubules, Proximal, Mice, Mice, Inbred BALB C, Mice, Knockout, Receptor, Notch2, Recovery of Function, Reperfusion Injury, Repressor Proteins, STAT3 Transcription Factor, Survivin, Up-Regulation
Added January 28, 2014
1 Communities
1 Members
0 Resources
17 MeSH Terms
Trastuzumab-resistant cells rely on a HER2-PI3K-FoxO-survivin axis and are sensitive to PI3K inhibitors.
Chakrabarty A, Bhola NE, Sutton C, Ghosh R, Kuba MG, Dave B, Chang JC, Arteaga CL
(2013) Cancer Res 73: 1190-200
MeSH Terms: Animals, Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Drug Resistance, Neoplasm, Female, Forkhead Box Protein O1, Forkhead Box Protein O3, Forkhead Transcription Factors, Humans, Inhibitor of Apoptosis Proteins, Mice, Neoplastic Stem Cells, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Receptor, ErbB-2, Survivin, Trastuzumab
Added September 3, 2013
0 Communities
2 Members
0 Resources
17 MeSH Terms
XZH-5 inhibits STAT3 phosphorylation and enhances the cytotoxicity of chemotherapeutic drugs in human breast and pancreatic cancer cells.
Liu A, Liu Y, Jin Z, Hu Q, Lin L, Jou D, Yang J, Xu Z, Wang H, Li C, Lin J
(2012) PLoS One 7: e46624
MeSH Terms: Animals, Apoptosis, Blotting, Western, Breast Neoplasms, Cell Line, Tumor, Cell Movement, Cyclin D1, Female, HeLa Cells, Histidine, Humans, Inhibitor of Apoptosis Proteins, Interleukin-6, Mice, Mice, SCID, Pancreatic Neoplasms, Phenylurea Compounds, Phosphorylation, Proto-Oncogene Proteins c-bcl-2, Reverse Transcriptase Polymerase Chain Reaction, STAT1 Transcription Factor, STAT3 Transcription Factor, Survivin
Added June 14, 2013
0 Communities
1 Members
0 Resources
23 MeSH Terms
Blockade of prostaglandin E2 signaling through EP1 and EP3 receptors attenuates Flt3L-dependent dendritic cell development from hematopoietic progenitor cells.
Singh P, Hoggatt J, Hu P, Speth JM, Fukuda S, Breyer RM, Pelus LM
(2012) Blood 119: 1671-82
MeSH Terms: Animals, Cell Differentiation, Cells, Cultured, Dendritic Cells, Dinoprostone, Hematopoietic Stem Cells, Hormone Antagonists, Humans, Infant, Newborn, Inhibitor of Apoptosis Proteins, Membrane Proteins, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptors, Prostaglandin E, EP1 Subtype, Receptors, Prostaglandin E, EP3 Subtype, STAT3 Transcription Factor, Signal Transduction, Survivin
Added December 21, 2013
1 Communities
1 Members
0 Resources
19 MeSH Terms
β-Catenin and K-RAS synergize to form primitive renal epithelial tumors with features of epithelial Wilms' tumors.
Clark PE, Polosukhina D, Love H, Correa H, Coffin C, Perlman EJ, de Caestecker M, Moses HL, Zent R
(2011) Am J Pathol 179: 3045-55
MeSH Terms: Animals, Apoptosis Regulatory Proteins, Cell Transformation, Neoplastic, Exons, Genes, ras, Humans, Inhibitor of Apoptosis Proteins, Kidney Neoplasms, Kidney Tubules, Proximal, MAP Kinase Signaling System, Mice, Mice, Transgenic, Mutation, Nuclear Proteins, PAX2 Transcription Factor, PAX8 Transcription Factor, Paired Box Transcription Factors, Phosphatidylinositol 3-Kinase, Phosphatidylinositol 3-Kinases, Repressor Proteins, Signal Transduction, Survivin, Wilms Tumor, beta Catenin
Added February 17, 2014
4 Communities
5 Members
0 Resources
24 MeSH Terms
Survivin depletion preferentially reduces the survival of activated K-Ras-transformed cells.
Sarthy AV, Morgan-Lappe SE, Zakula D, Vernetti L, Schurdak M, Packer JC, Anderson MG, Shirasawa S, Sasazuki T, Fesik SW
(2007) Mol Cancer Ther 6: 269-76
MeSH Terms: Alleles, Apoptosis, Cell Death, Cell Survival, Cell Transformation, Neoplastic, Clone Cells, G2 Phase, Genes, Neoplasm, Genes, ras, Humans, Inhibitor of Apoptosis Proteins, Microtubule-Associated Proteins, Mitosis, Mutant Proteins, Neoplasm Proteins, Polyploidy, RNA, Small Interfering, Survivin
Added March 5, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms