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Interaction of α Carboxyl Terminus 1 Peptide With the Connexin 43 Carboxyl Terminus Preserves Left Ventricular Function After Ischemia-Reperfusion Injury.
Jiang J, Hoagland D, Palatinus JA, He H, Iyyathurai J, Jourdan LJ, Bultynck G, Wang Z, Zhang Z, Schey K, Poelzing S, McGowan FX, Gourdie RG
(2019) J Am Heart Assoc 8: e012385
MeSH Terms: Animals, Computer Simulation, Connexin 43, Mice, Microscopy, Confocal, Myocardial Contraction, Myocardial Reperfusion Injury, Peptide Fragments, Phosphorylation, Surface Plasmon Resonance, Tandem Mass Spectrometry, Ventricular Function, Left, Zonula Occludens-1 Protein
Added March 24, 2020
0 Communities
1 Members
0 Resources
13 MeSH Terms
Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors.
Li B, Orton D, Neitzel LR, Astudillo L, Shen C, Long J, Chen X, Kirkbride KC, Doundoulakis T, Guerra ML, Zaias J, Fei DL, Rodriguez-Blanco J, Thorne C, Wang Z, Jin K, Nguyen DM, Sands LR, Marchetti F, Abreu MT, Cobb MH, Capobianco AJ, Lee E, Robbins DJ
(2017) Sci Signal 10:
MeSH Terms: Animals, Antineoplastic Agents, Benzoates, Casein Kinase Ialpha, Enzyme Activation, Enzyme Activators, Gene Expression Regulation, Neoplastic, HCT116 Cells, Humans, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Nude, Neoplasm Metastasis, Neoplasms, Organ Culture Techniques, Phosphorylation, Pyrvinium Compounds, Signal Transduction, Surface Plasmon Resonance, Wnt Proteins, Wnt Signaling Pathway, Xenograft Model Antitumor Assays, Xenopus laevis
Added July 18, 2017
0 Communities
1 Members
0 Resources
24 MeSH Terms
Rearrangement of the Extracellular Domain/Extracellular Loop 1 Interface Is Critical for Thyrotropin Receptor Activation.
Schaarschmidt J, Nagel MBM, Huth S, Jaeschke H, Moretti R, Hintze V, von Bergen M, Kalkhof S, Meiler J, Paschke R
(2016) J Biol Chem 291: 14095-14108
MeSH Terms: Animals, CHO Cells, Cricetinae, Cricetulus, Glycosylation, Humans, Mass Spectrometry, Models, Molecular, Mutation, Proteolysis, Receptors, Thyrotropin, Surface Plasmon Resonance
Added April 8, 2017
1 Communities
1 Members
0 Resources
12 MeSH Terms
The catalytic domains of Clostridium sordellii lethal toxin and related large clostridial glucosylating toxins specifically recognize the negatively charged phospholipids phosphatidylserine and phosphatidic acid.
Varela Chavez C, Hoos S, Haustant GM, Chenal A, England P, Blondel A, Pauillac S, Lacy DB, Popoff MR
(2015) Cell Microbiol 17: 1477-93
MeSH Terms: Anions, Bacterial Toxins, Binding Sites, Catalytic Domain, Cell Membrane, Enzyme-Linked Immunosorbent Assay, Phosphatidic Acids, Phosphatidylserines, Protein Binding, Surface Plasmon Resonance
Added September 28, 2015
0 Communities
1 Members
0 Resources
10 MeSH Terms
Analysis of nidogen-1/laminin γ1 interaction by cross-linking, mass spectrometry, and computational modeling reveals multiple binding modes.
Lössl P, Kölbel K, Tänzler D, Nannemann D, Ihling CH, Keller MV, Schneider M, Zaucke F, Meiler J, Sinz A
(2014) PLoS One 9: e112886
MeSH Terms: Animals, Cross-Linking Reagents, HEK293 Cells, Humans, Kinetics, Laminin, Membrane Glycoproteins, Mice, Models, Molecular, Protein Structure, Tertiary, Surface Plasmon Resonance, Tandem Mass Spectrometry
Added January 24, 2015
1 Communities
1 Members
0 Resources
12 MeSH Terms
The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1.
Blind RD, Sablin EP, Kuchenbecker KM, Chiu HJ, Deacon AM, Das D, Fletterick RJ, Ingraham HA
(2014) Proc Natl Acad Sci U S A 111: 15054-9
MeSH Terms: Amino Acids, Animals, Biological Transport, Cell Nucleus, Chromatography, Computer Simulation, Crystallography, X-Ray, Electrons, Humans, Ligands, Lipids, Mice, Models, Molecular, Molecular Conformation, Mutation, Mutation, Missense, Peptides, Phosphatidylinositols, Signal Transduction, Solvents, Steroidogenic Factor 1, Surface Plasmon Resonance, Surface Properties, Temperature, Water
Added August 18, 2015
0 Communities
1 Members
0 Resources
25 MeSH Terms
Ultra-compact silicon photonic devices reconfigured by an optically induced semiconductor-to-metal transition.
Ryckman JD, Hallman KA, Marvel RE, Haglund RF, Weiss SM
(2013) Opt Express 21: 10753-63
MeSH Terms: Equipment Design, Equipment Failure Analysis, Miniaturization, Photons, Semiconductors, Silicon, Surface Plasmon Resonance
Added April 27, 2017
0 Communities
1 Members
0 Resources
7 MeSH Terms
Fiber-to-chip coupler designed using an optical transformation.
Markov P, Valentine JG, Weiss SM
(2012) Opt Express 20: 14705-13
MeSH Terms: Electronics, Equipment Design, Equipment Failure Analysis, Fiber Optic Technology, Optical Devices, Silicon, Surface Plasmon Resonance, Transducers
Added April 27, 2017
0 Communities
1 Members
0 Resources
8 MeSH Terms
Mutation in cyclophilin B that causes hyperelastosis cutis in American Quarter Horse does not affect peptidylprolyl cis-trans isomerase activity but shows altered cyclophilin B-protein interactions and affects collagen folding.
Ishikawa Y, Vranka JA, Boudko SP, Pokidysheva E, Mizuno K, Zientek K, Keene DR, Rashmir-Raven AM, Nagata K, Winand NJ, Bächinger HP
(2012) J Biol Chem 287: 22253-65
MeSH Terms: Animals, Asthenia, Circular Dichroism, Collagen, Cyclophilins, Endoplasmic Reticulum, Rough, Horses, Kinetics, Mice, Mice, Transgenic, Molecular Chaperones, Mutation, Peptidylprolyl Isomerase, Protein Binding, Protein Folding, Protein Structure, Tertiary, Skin Diseases, Surface Plasmon Resonance, cis-trans-Isomerases
Added November 2, 2017
0 Communities
1 Members
0 Resources
19 MeSH Terms
Structural basis of thrombin-mediated factor V activation: the Glu666-Glu672 sequence is critical for processing at the heavy chain-B domain junction.
Corral-Rodríguez MÁ, Bock PE, Hernández-Carvajal E, Gutiérrez-Gallego R, Fuentes-Prior P
(2011) Blood 117: 7164-73
MeSH Terms: Amino Acid Chloromethyl Ketones, Amino Acid Sequence, Antithrombins, Benzamidines, Biocatalysis, Catalytic Domain, Crystallography, X-Ray, Enzyme Activation, Enzymes, Immobilized, Factor V, Factor Va, Humans, Kinetics, Models, Molecular, Peptide Fragments, Protein Conformation, Protein Interaction Domains and Motifs, Recombinant Proteins, Spectrometry, Fluorescence, Surface Plasmon Resonance, Surface Properties, Thrombin
Added January 20, 2015
0 Communities
1 Members
0 Resources
22 MeSH Terms