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Exploring genetic suppression interactions on a global scale.
van Leeuwen J, Pons C, Mellor JC, Yamaguchi TN, Friesen H, Koschwanez J, Ušaj MM, Pechlaner M, Takar M, Ušaj M, VanderSluis B, Andrusiak K, Bansal P, Baryshnikova A, Boone CE, Cao J, Cote A, Gebbia M, Horecka G, Horecka I, Kuzmin E, Legro N, Liang W, van Lieshout N, McNee M, San Luis BJ, Shaeri F, Shuteriqi E, Sun S, Yang L, Youn JY, Yuen M, Costanzo M, Gingras AC, Aloy P, Oostenbrink C, Murray A, Graham TR, Myers CL, Andrews BJ, Roth FP, Boone C
(2016) Science 354:
MeSH Terms: Cell Physiological Phenomena, Chromosome Mapping, Gene Regulatory Networks, Genes, Fungal, Genes, Suppressor, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Suppression, Genetic
Added April 6, 2017
0 Communities
1 Members
0 Resources
8 MeSH Terms
Compensatory substitutions in the HIV-1 capsid reduce the fitness cost associated with resistance to a capsid-targeting small-molecule inhibitor.
Shi J, Zhou J, Halambage UD, Shah VB, Burse MJ, Wu H, Blair WS, Butler SL, Aiken C
(2015) J Virol 89: 208-19
MeSH Terms: Amino Acid Substitution, Anti-HIV Agents, Cells, Cultured, Drug Resistance, Viral, HIV Core Protein p24, HIV-1, Humans, Indoles, Macrophages, Mutant Proteins, Mutation, Missense, Phenylalanine, Selection, Genetic, Suppression, Genetic, Virus Replication
Added February 19, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms
Second-site suppressors of HIV-1 capsid mutations: restoration of intracellular activities without correction of intrinsic capsid stability defects.
Yang R, Shi J, Byeon IJ, Ahn J, Sheehan JH, Meiler J, Gronenborn AM, Aiken C
(2012) Retrovirology 9: 30
MeSH Terms: Amino Acid Substitution, Capsid Proteins, Cell Line, HIV-1, Humans, Mutant Proteins, Mutation, Missense, Protein Stability, Suppression, Genetic, T-Lymphocytes, Virus Uncoating
Added April 25, 2013
1 Communities
3 Members
0 Resources
11 MeSH Terms
A novel class of mutations that affect DNA replication in E. coli.
Nordman J, Skovgaard O, Wright A
(2007) Mol Microbiol 64: 125-38
MeSH Terms: Bacterial Proteins, Cold Temperature, DNA Replication, DNA Transposable Elements, DNA, Bacterial, DNA-Binding Proteins, Escherichia coli K12, Escherichia coli Proteins, Flow Cytometry, Hydroxyurea, Mutagenesis, Insertional, Mutation, Suppression, Genetic
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
A mutation in alpha helix 3 of CA renders human immunodeficiency virus type 1 cyclosporin A resistant and dependent: rescue by a second-site substitution in a distal region of CA.
Yang R, Aiken C
(2007) J Virol 81: 3749-56
MeSH Terms: Amino Acid Substitution, Anti-HIV Agents, Cell Line, Cyclosporine, Drug Resistance, Viral, HIV Core Protein p24, HIV-1, HeLa Cells, Humans, Mutation, RNA Interference, Suppression, Genetic, Virus Replication
Added February 19, 2015
0 Communities
1 Members
0 Resources
13 MeSH Terms
C. elegans HIM-8 functions outside of meiosis to antagonize EGL-13 Sox protein function.
Nelms BL, Hanna-Rose W
(2006) Dev Biol 293: 392-402
MeSH Terms: Alleles, Animals, Animals, Genetically Modified, Base Sequence, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Cell Cycle Proteins, DNA, Helminth, Female, Genes, Helminth, Male, Meiosis, Mutation, RNA Interference, Suppression, Genetic, Transcription Factors, Uterus, Vulva
Added April 7, 2010
0 Communities
1 Members
0 Resources
18 MeSH Terms
A mutation in the human immunodeficiency virus type 1 Gag protein destabilizes the interaction of the envelope protein subunits gp120 and gp41.
Davis MR, Jiang J, Zhou J, Freed EO, Aiken C
(2006) J Virol 80: 2405-17
MeSH Terms: Amino Acid Motifs, Amino Acid Substitution, Cell Line, Gene Products, gag, HIV Envelope Protein gp120, HIV Envelope Protein gp41, HIV-1, Humans, Mutation, Protein Binding, Protein Structure, Tertiary, Sequence Deletion, Suppression, Genetic, T-Lymphocytes, Vesicular stomatitis Indiana virus, Virion, Virus Assembly, Virus Replication
Added February 19, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms
The alpha1 subunit of GABAA receptor is repressed by c-myc and is pro-apoptotic.
Vaknin UA, Hann SR
(2006) J Cell Biochem 97: 1094-103
MeSH Terms: Animals, Apoptosis, Caspase 3, Caspases, Gene Expression Profiling, Gene Expression Regulation, Mice, NIH 3T3 Cells, Proto-Oncogene Proteins c-myc, RNA, Messenger, Rats, Receptors, GABA-A, Suppression, Genetic, Transcription, Genetic
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis.
Cardone M, Kandilci A, Carella C, Nilsson JA, Brennan JA, Sirma S, Ozbek U, Boyd K, Cleveland JL, Grosveld GC
(2005) Mol Cell Biol 25: 2395-405
MeSH Terms: Animals, Apoptosis, B-Lymphocytes, Burkitt Lymphoma, Cell Proliferation, Child, DNA-Binding Proteins, Female, Humans, Male, Mice, Mice, Transgenic, Mutation, Proto-Oncogene Proteins c-ets, Proto-Oncogene Proteins c-myc, Suppression, Genetic, Transcription Factors, Tumor Suppressor Protein p53, Up-Regulation
Added March 5, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
A genetic screen for suppressors and enhancers of the Drosophila PAN GU cell cycle kinase identifies cyclin B as a target.
Lee LA, Elfring LK, Bosco G, Orr-Weaver TL
(2001) Genetics 158: 1545-56
MeSH Terms: Animals, Cell Cycle, Cell Nucleus, Crosses, Genetic, Cyclin B, Drosophila, Drosophila Proteins, Genotype, Hot Temperature, Immunoblotting, Mutation, Peptide Initiation Factors, Phenotype, Protein Biosynthesis, Protein Serine-Threonine Kinases, RNA-Binding Proteins, Suppression, Genetic
Added March 5, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms