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Tobacco smoking induces cardiovascular mitochondrial oxidative stress, promotes endothelial dysfunction, and enhances hypertension.
Dikalov S, Itani H, Richmond B, Vergeade A, Rahman SMJ, Boutaud O, Blackwell T, Massion PP, Harrison DG, Dikalova A
(2019) Am J Physiol Heart Circ Physiol 316: H639-H646
MeSH Terms: Angiotensin II, Animals, Blood Pressure, Calcium Channels, Endothelium, Vascular, Hydrogen Peroxide, Hypertension, Mice, Mice, Inbred C57BL, Mice, Transgenic, Mitochondria, Heart, Oxidative Stress, Superoxide Dismutase, TRPV Cation Channels, Tobacco Smoking, Vasoconstrictor Agents
Added March 26, 2019
0 Communities
1 Members
0 Resources
16 MeSH Terms
A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension.
Hemnes AR, Rathinasabapathy A, Austin EA, Brittain EL, Carrier EJ, Chen X, Fessel JP, Fike CD, Fong P, Fortune N, Gerszten RE, Johnson JA, Kaplowitz M, Newman JH, Piana R, Pugh ME, Rice TW, Robbins IM, Wheeler L, Yu C, Loyd JE, West J
(2018) Eur Respir J 51:
MeSH Terms: Adult, Aged, Angiotensin-Converting Enzyme 2, Animals, Biomarkers, Cytokines, Female, Gene Expression, Humans, Hypertension, Pulmonary, Male, Middle Aged, Peptidyl-Dipeptidase A, Pilot Projects, Proof of Concept Study, Proto-Oncogene Mas, Proto-Oncogene Proteins, Pulmonary Artery, Receptors, G-Protein-Coupled, Superoxide Dismutase, Swine, Vascular Resistance
Added March 26, 2019
0 Communities
3 Members
0 Resources
22 MeSH Terms
Introduction to Metals in Biology 2018: Copper homeostasis and utilization in redox enzymes.
Guengerich FP
(2018) J Biol Chem 293: 4603-4605
MeSH Terms: Animals, Copper, Electron Transport Complex IV, Humans, Superoxide Dismutase
Added March 14, 2018
0 Communities
1 Members
0 Resources
5 MeSH Terms
Sirt3 Impairment and SOD2 Hyperacetylation in Vascular Oxidative Stress and Hypertension.
Dikalova AE, Itani HA, Nazarewicz RR, McMaster WG, Flynn CR, Uzhachenko R, Fessel JP, Gamboa JL, Harrison DG, Dikalov SI
(2017) Circ Res 121: 564-574
MeSH Terms: Acetylation, Animals, Cells, Cultured, Humans, Hypertension, Mice, Mice, Inbred C57BL, Mice, Knockout, Oxidative Stress, Sirtuin 3, Superoxide Dismutase
Added March 14, 2018
0 Communities
3 Members
0 Resources
11 MeSH Terms
A Superoxide Dismutase Capable of Functioning with Iron or Manganese Promotes the Resistance of Staphylococcus aureus to Calprotectin and Nutritional Immunity.
Garcia YM, Barwinska-Sendra A, Tarrant E, Skaar EP, Waldron KJ, Kehl-Fie TE
(2017) PLoS Pathog 13: e1006125
MeSH Terms: Animals, Chromatography, Ion Exchange, Disease Models, Animal, Iron, Leukocyte L1 Antigen Complex, Manganese, Mass Spectrometry, Mice, Mice, Inbred C57BL, Polymerase Chain Reaction, Staphylococcal Infections, Staphylococcus aureus, Superoxide Dismutase
Added April 8, 2017
0 Communities
1 Members
0 Resources
13 MeSH Terms
LRRC8A channels support TNFα-induced superoxide production by Nox1 which is required for receptor endocytosis.
Choi H, Ettinger N, Rohrbough J, Dikalova A, Nguyen HN, Lamb FS
(2016) Free Radic Biol Med 101: 413-423
MeSH Terms: Cell Line, Cyclopentanes, Endocytosis, Gene Expression Regulation, HEK293 Cells, Humans, Indans, JNK Mitogen-Activated Protein Kinases, Membrane Proteins, Myocytes, Smooth Muscle, NADPH Oxidase 1, NF-kappa B, Phosphorylation, Protein Subunits, RNA, Small Interfering, Receptors, Tumor Necrosis Factor, Type I, Signal Transduction, Superoxide Dismutase, Superoxides, Tumor Necrosis Factor-alpha, Vascular Cell Adhesion Molecule-1
Added March 26, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Contribution of mitochondrial oxidative stress to hypertension.
Dikalov SI, Dikalova AE
(2016) Curr Opin Nephrol Hypertens 25: 73-80
MeSH Terms: Aging, Angiotensin II, Animals, Caloric Restriction, Humans, Hypertension, Mitochondria, Motor Activity, Oxidative Stress, Reactive Oxygen Species, Sirtuin 3, Smoking, Superoxide Dismutase
Added February 17, 2016
0 Communities
1 Members
0 Resources
13 MeSH Terms
5'-O-Alkylpyridoxamines: Lipophilic Analogues of Pyridoxamine Are Potent Scavengers of 1,2-Dicarbonyls.
Amarnath V, Amarnath K, Avance J, Stec DF, Voziyan P
(2015) Chem Res Toxicol 28: 1469-75
MeSH Terms: Biocatalysis, Electron Spin Resonance Spectroscopy, Free Radical Scavengers, Free Radicals, Glucose, Horseradish Peroxidase, Hydrophobic and Hydrophilic Interactions, Membrane Proteins, Molecular Conformation, Muramidase, Pyridoxamine, Pyruvaldehyde, Spectrophotometry, Ultraviolet, Superoxide Dismutase
Added June 9, 2017
1 Communities
2 Members
0 Resources
14 MeSH Terms
Cellular oxidative stress response mediates radiosensitivity in Fus1-deficient mice.
Yazlovitskaya EM, Voziyan PA, Manavalan T, Yarbrough WG, Ivanova AV
(2015) Cell Death Dis 6: e1652
MeSH Terms: Animals, Cytochromes c, DNA Damage, Female, Mice, Mice, Knockout, Oxidative Stress, Radiation Tolerance, STAT3 Transcription Factor, Superoxide Dismutase, Tumor Suppressor Proteins
Added June 9, 2017
1 Communities
2 Members
0 Resources
11 MeSH Terms
Selective depletion of vascular EC-SOD augments chronic hypoxic pulmonary hypertension.
Nozik-Grayck E, Woods C, Taylor JM, Benninger RK, Johnson RD, Villegas LR, Stenmark KR, Harrison DG, Majka SM, Irwin D, Farrow KN
(2014) Am J Physiol Lung Cell Mol Physiol 307: L868-76
MeSH Terms: Animals, Blood Pressure, Cyclic GMP, Cyclic Nucleotide Phosphodiesterases, Type 5, Estrogen Antagonists, GTP Cyclohydrolase, Guanylate Cyclase, Hypertension, Pulmonary, Hypertrophy, Right Ventricular, Hypoxia, Lung, Mice, Mice, Knockout, Nitric Oxide Synthase Type III, Pulmonary Artery, Receptors, Cytoplasmic and Nuclear, Signal Transduction, Soluble Guanylyl Cyclase, Superoxide Dismutase, Tamoxifen
Added March 31, 2015
1 Communities
2 Members
0 Resources
20 MeSH Terms