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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 35

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Symmetrically substituted dichlorophenes inhibit -acyl-phosphatidylethanolamine phospholipase D.
Aggarwal G, Zarrow JE, Mashhadi Z, Flynn CR, Vinson P, Weaver CD, Davies SS
(2020) J Biol Chem 295: 7289-7300
MeSH Terms: Animals, Bacterial Proteins, Bithionol, Dichlorophen, Enzyme Inhibitors, HEK293 Cells, Hexachlorophene, Humans, Mice, Phospholipase D, Quinazolines, Streptomyces, Sulfonamides
Added August 18, 2020
0 Communities
1 Members
0 Resources
13 MeSH Terms
Amycomicin is a potent and specific antibiotic discovered with a targeted interaction screen.
Pishchany G, Mevers E, Ndousse-Fetter S, Horvath DJ, Paludo CR, Silva-Junior EA, Koren S, Skaar EP, Clardy J, Kolter R
(2018) Proc Natl Acad Sci U S A 115: 10124-10129
MeSH Terms: Anthraquinones, Anti-Bacterial Agents, DNA, Bacterial, DNA, Ribosomal, Microbial Sensitivity Tests, RNA, Ribosomal, 16S, Streptomyces coelicolor
Added April 7, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics.
Earl DC, Ferrell PB, Leelatian N, Froese JT, Reisman BJ, Irish JM, Bachmann BO
(2018) Nat Commun 9: 39
MeSH Terms: Aged, Bone Marrow, Cell Extracts, Chromatography, Liquid, DNA Damage, Female, Flow Cytometry, Humans, Leukemia, Leukemia, Myeloid, Acute, Lymphocytes, Male, Mass Spectrometry, Metabolome, Metabolomics, Monocytes, Signal Transduction, Streptomyces, Tumor Cells, Cultured, Young Adult
Added January 4, 2018
3 Communities
1 Members
0 Resources
20 MeSH Terms
Structure of a DNA glycosylase that unhooks interstrand cross-links.
Mullins EA, Warren GM, Bradley NP, Eichman BF
(2017) Proc Natl Acad Sci U S A 114: 4400-4405
MeSH Terms: Anti-Bacterial Agents, Bacterial Proteins, DNA Glycosylases, DNA, Bacterial, Gene Expression Regulation, Bacterial, Gene Expression Regulation, Enzymologic, Intercellular Signaling Peptides and Proteins, Models, Molecular, Mutation, Naphthalenes, Peptides, Protein Binding, Protein Conformation, Protein Folding, Streptomyces
Added August 26, 2019
0 Communities
1 Members
0 Resources
15 MeSH Terms
Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily.
McCulloch KM, McCranie EK, Smith JA, Sarwar M, Mathieu JL, Gitschlag BL, Du Y, Bachmann BO, Iverson TM
(2015) Proc Natl Acad Sci U S A 112: 11547-52
MeSH Terms: Aminoglycosides, Anti-Bacterial Agents, Catalytic Domain, Crystallography, X-Ray, Cyclization, Hydrogen, Hygromycin B, Metals, Micromonospora, Multigene Family, Oligosaccharides, Open Reading Frames, Oxidation-Reduction, Oxygen, Oxygenases, Phylogeny, Protein Binding, Protein Structure, Secondary, Reproducibility of Results, Streptomyces
Added April 1, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins.
Zdżalik D, Domańska A, Prorok P, Kosicki K, van den Born E, Falnes PØ, Rizzo CJ, Guengerich FP, Tudek B
(2015) DNA Repair (Amst) 30: 1-10
MeSH Terms: Adenine, AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase, AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase, Bacteria, Bacterial Proteins, Cytosine, DNA, DNA Adducts, DNA Glycosylases, DNA Repair, DNA Repair Enzymes, DNA, Single-Stranded, Dioxygenases, Escherichia coli, Escherichia coli Proteins, Guanine, Humans, Mixed Function Oxygenases, Mycobacterium tuberculosis, Rhizobium etli, Streptomyces, Substrate Specificity, Xanthomonas campestris
Added January 7, 2016
0 Communities
2 Members
0 Resources
23 MeSH Terms
Streptomyces cytochromes P450: applications in drug metabolism.
Lamb DC, Waterman MR, Zhao B
(2013) Expert Opin Drug Metab Toxicol 9: 1279-94
MeSH Terms: Biotransformation, Cytochrome P-450 Enzyme System, Drug Evaluation, Preclinical, Drug-Related Side Effects and Adverse Reactions, Genomics, Humans, Inactivation, Metabolic, Streptomyces, Xenobiotics
Added March 7, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
Cytochrome P450 107U1 is required for sporulation and antibiotic production in Streptomyces coelicolor.
Tian Z, Cheng Q, Yoshimoto FK, Lei L, Lamb DC, Guengerich FP
(2013) Arch Biochem Biophys 530: 101-7
MeSH Terms: Anti-Bacterial Agents, Bacterial Proteins, Cytochrome P-450 Enzyme System, Glycochenodeoxycholic Acid, Mutation, Oxidation-Reduction, Streptomyces coelicolor
Added March 7, 2014
0 Communities
1 Members
0 Resources
7 MeSH Terms
Structural analysis of cytochrome P450 105N1 involved in the biosynthesis of the zincophore, coelibactin.
Zhao B, Moody SC, Hider RC, Lei L, Kelly SL, Waterman MR, Lamb DC
(2012) Int J Mol Sci 13: 8500-13
MeSH Terms: Bacterial Proteins, Catalytic Domain, Crystallography, X-Ray, Cytochrome P-450 Enzyme System, Models, Molecular, Oxazoles, Protein Structure, Secondary, Siderophores, Streptomyces coelicolor, Thiazoles, Zinc
Added February 12, 2015
0 Communities
1 Members
0 Resources
11 MeSH Terms
The role of Ile87 of CYP158A2 in oxidative coupling reaction.
Zhao B, Bellamine A, Lei L, Waterman MR
(2012) Arch Biochem Biophys 518: 127-32
MeSH Terms: Amino Acid Substitution, Bacterial Proteins, Biflavonoids, Catalysis, Catalytic Domain, Crystallography, X-Ray, Cytochrome P-450 Enzyme System, Isoleucine, Mutation, Missense, Oxidation-Reduction, Streptomyces coelicolor
Added February 12, 2015
0 Communities
1 Members
0 Resources
11 MeSH Terms