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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 18

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Amycomicin is a potent and specific antibiotic discovered with a targeted interaction screen.
Pishchany G, Mevers E, Ndousse-Fetter S, Horvath DJ, Paludo CR, Silva-Junior EA, Koren S, Skaar EP, Clardy J, Kolter R
(2018) Proc Natl Acad Sci U S A 115: 10124-10129
MeSH Terms: Anthraquinones, Anti-Bacterial Agents, DNA, Bacterial, DNA, Ribosomal, Microbial Sensitivity Tests, RNA, Ribosomal, 16S, Streptomyces coelicolor
Added April 7, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Cytochrome P450 107U1 is required for sporulation and antibiotic production in Streptomyces coelicolor.
Tian Z, Cheng Q, Yoshimoto FK, Lei L, Lamb DC, Guengerich FP
(2013) Arch Biochem Biophys 530: 101-7
MeSH Terms: Anti-Bacterial Agents, Bacterial Proteins, Cytochrome P-450 Enzyme System, Glycochenodeoxycholic Acid, Mutation, Oxidation-Reduction, Streptomyces coelicolor
Added March 7, 2014
0 Communities
1 Members
0 Resources
7 MeSH Terms
Structural analysis of cytochrome P450 105N1 involved in the biosynthesis of the zincophore, coelibactin.
Zhao B, Moody SC, Hider RC, Lei L, Kelly SL, Waterman MR, Lamb DC
(2012) Int J Mol Sci 13: 8500-13
MeSH Terms: Bacterial Proteins, Catalytic Domain, Crystallography, X-Ray, Cytochrome P-450 Enzyme System, Models, Molecular, Oxazoles, Protein Structure, Secondary, Siderophores, Streptomyces coelicolor, Thiazoles, Zinc
Added February 12, 2015
0 Communities
1 Members
0 Resources
11 MeSH Terms
The role of Ile87 of CYP158A2 in oxidative coupling reaction.
Zhao B, Bellamine A, Lei L, Waterman MR
(2012) Arch Biochem Biophys 518: 127-32
MeSH Terms: Amino Acid Substitution, Bacterial Proteins, Biflavonoids, Catalysis, Catalytic Domain, Crystallography, X-Ray, Cytochrome P-450 Enzyme System, Isoleucine, Mutation, Missense, Oxidation-Reduction, Streptomyces coelicolor
Added February 12, 2015
0 Communities
1 Members
0 Resources
11 MeSH Terms
Investigating conservation of the albaflavenone biosynthetic pathway and CYP170 bifunctionality in streptomycetes.
Moody SC, Zhao B, Lei L, Nelson DR, Mullins JG, Waterman MR, Kelly SL, Lamb DC
(2012) FEBS J 279: 1640-9
MeSH Terms: Alkyl and Aryl Transferases, Amino Acid Sequence, Catalytic Domain, Cytochrome P-450 Enzyme System, Models, Molecular, Molecular Sequence Data, Polyisoprenyl Phosphates, Sesquiterpenes, Streptomyces, Streptomyces coelicolor
Added February 12, 2015
0 Communities
1 Members
0 Resources
10 MeSH Terms
Cyclization of a cellular dipentaenone by Streptomyces coelicolor cytochrome P450 154A1 without oxidation/reduction.
Cheng Q, Lamb DC, Kelly SL, Lei L, Guengerich FP
(2010) J Am Chem Soc 132: 15173-5
MeSH Terms: Chromatography, High Pressure Liquid, Cyclization, Cytochrome P-450 Enzyme System, Oxidation-Reduction, Pentanones, Streptomyces coelicolor
Added March 7, 2014
0 Communities
1 Members
0 Resources
6 MeSH Terms
Approaches to deorphanization of human and microbial cytochrome P450 enzymes.
Guengerich FP, Tang Z, Cheng Q, Salamanca-Pinzón SG
(2011) Biochim Biophys Acta 1814: 139-45
MeSH Terms: Bacterial Proteins, Carcinogens, Chromatography, Liquid, Cytochrome P-450 Enzyme System, Humans, Isoenzymes, Mass Spectrometry, Multigene Family, Streptomyces coelicolor, Substrate Specificity
Added March 26, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Streptomyces coelicolor A3(2) CYP102 protein, a novel fatty acid hydroxylase encoded as a heme domain without an N-terminal redox partner.
Lamb DC, Lei L, Zhao B, Yuan H, Jackson CJ, Warrilow AG, Skaug T, Dyson PJ, Dawson ES, Kelly SL, Hachey DL, Waterman MR
(2010) Appl Environ Microbiol 76: 1975-80
MeSH Terms: 8,11,14-Eicosatrienoic Acid, Arachidonic Acid, Cloning, Molecular, Cytochrome P-450 Enzyme System, DNA Transposable Elements, Escherichia coli, Ferredoxin-NADP Reductase, Ferredoxins, Gene Expression, Mixed Function Oxygenases, Mutagenesis, Insertional, NADP, Streptomyces coelicolor, Substrate Specificity
Added March 20, 2014
0 Communities
2 Members
0 Resources
14 MeSH Terms
Crystal structure of albaflavenone monooxygenase containing a moonlighting terpene synthase active site.
Zhao B, Lei L, Vassylyev DG, Lin X, Cane DE, Kelly SL, Yuan H, Lamb DC, Waterman MR
(2009) J Biol Chem 284: 36711-36719
MeSH Terms: Alkyl and Aryl Transferases, Bacterial Proteins, Catalytic Domain, Crystallography, X-Ray, Cytochrome P-450 Enzyme System, Heme, Iron, Polyisoprenyl Phosphates, Protein Binding, Protein Structure, Secondary, Protein Structure, Tertiary, Sesquiterpenes, Streptomyces coelicolor
Added February 12, 2015
0 Communities
1 Members
0 Resources
13 MeSH Terms
Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2).
Zhao B, Lin X, Lei L, Lamb DC, Kelly SL, Waterman MR, Cane DE
(2008) J Biol Chem 283: 8183-9
MeSH Terms: Anti-Bacterial Agents, Catalysis, Cytochrome P-450 Enzyme System, Flavodoxin, Gas Chromatography-Mass Spectrometry, Magnetic Resonance Spectroscopy, Molecular Structure, NADH, NADPH Oxidoreductases, Sesquiterpenes, Streptomyces coelicolor
Added February 12, 2015
0 Communities
1 Members
0 Resources
10 MeSH Terms