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Results: 1 to 10 of 51

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7-Ketocholesterol in disease and aging.
Anderson A, Campo A, Fulton E, Corwin A, Jerome WG, O'Connor MS
(2020) Redox Biol 29: 101380
MeSH Terms: Humans, Ketocholesterols
Added March 3, 2020
0 Communities
1 Members
0 Resources
2 MeSH Terms
The synthetic neuroactive steroid SGE-516 reduces seizure burden and improves survival in a Dravet syndrome mouse model.
Hawkins NA, Lewis M, Hammond RS, Doherty JJ, Kearney JA
(2017) Sci Rep 7: 15327
MeSH Terms: Animals, Anticonvulsants, Epilepsies, Myoclonic, GABA-A Receptor Agonists, Hydroxycholesterols, Mice, Mice, Mutant Strains, NAV1.1 Voltage-Gated Sodium Channel, Receptors, GABA-A
Added October 2, 2018
1 Communities
0 Members
0 Resources
9 MeSH Terms
The Role of Oxysterols in Human Cancer.
Kloudova A, Guengerich FP, Soucek P
(2017) Trends Endocrinol Metab 28: 485-496
MeSH Terms: Animals, Cholesterol, Female, Humans, Hydroxycholesterols, Lipid Metabolism, Male, Metabolic Networks and Pathways, Neoplasms
Added March 14, 2018
0 Communities
1 Members
0 Resources
9 MeSH Terms
Structural analyses of sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis.
Hargrove TY, Friggeri L, Wawrzak Z, Qi A, Hoekstra WJ, Schotzinger RJ, York JD, Guengerich FP, Lepesheva GI
(2017) J Biol Chem 292: 6728-6743
MeSH Terms: Animals, Antifungal Agents, Azoles, Candida albicans, Crystallization, Fungal Proteins, Heme, Humans, Kinetics, Ligands, Microbial Sensitivity Tests, Protein Binding, Protein Conformation, Protons, Rats, Sterol 14-Demethylase, Sterols
Added March 14, 2018
0 Communities
3 Members
0 Resources
17 MeSH Terms
Effect of psychotropic drug treatment on sterol metabolism.
Korade Ž, Liu W, Warren EB, Armstrong K, Porter NA, Konradi C
(2017) Schizophr Res 187: 74-81
MeSH Terms: Adult, Animals, Antidepressive Agents, Antipsychotic Agents, Body Mass Index, Cholestadienols, Clozapine, Dehydrocholesterols, Female, Haloperidol, Humans, Lipid Metabolism, Male, Mental Disorders, Psychiatric Status Rating Scales, Random Allocation, Rats, Sprague-Dawley, Weight Gain
Added April 6, 2017
0 Communities
1 Members
0 Resources
18 MeSH Terms
Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis.
Ačimovič J, Goyal S, Košir R, Goličnik M, Perše M, Belič A, Urlep Ž, Guengerich FP, Rozman D
(2016) Sci Rep 6: 28462
MeSH Terms: Animals, Cholesterol, Cyclic AMP Response Element Modulator, Cytochrome P-450 Enzyme System, Gas Chromatography-Mass Spectrometry, Humans, Lanosterol, Male, Mice, Mice, Knockout, Models, Theoretical, Oxidation-Reduction, Rats, Recombinant Proteins, Sterols, Testis
Added March 14, 2018
0 Communities
1 Members
0 Resources
16 MeSH Terms
Update to A.S.P.E.N. position paper: clinical role for alternative intravenous fat emulsions.
Vanek VW, Seidner DL, Allen P, Bistrian B, Collier S, Gura K, Miles JM, Valentine CJ, Novel Nutrient Task Force, American Society for Parenteral and Enteral Nutrition
(2014) Nutr Clin Pract 29: 841
MeSH Terms: Dietetics, Fat Emulsions, Intravenous, Fish Oils, Humans, Phytosterols, Plant Oils, Societies, Scientific, Triglycerides, United States
Added September 30, 2015
0 Communities
1 Members
0 Resources
9 MeSH Terms
Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.
Goyal S, Xiao Y, Porter NA, Xu L, Guengerich FP
(2014) J Lipid Res 55: 1933-43
MeSH Terms: Cholesterol 24-Hydroxylase, Dehydrocholesterols, Desmosterol, Humans, Kinetics, Oxidation-Reduction, Protein Binding, Steroid Hydroxylases
Added January 20, 2015
0 Communities
1 Members
0 Resources
8 MeSH Terms
Pigmented rice bran and plant sterol combination reduces serum lipids in overweight and obese adults.
Hongu N, Kitts DD, Zawistowski J, Dossett CM, Kopeć A, Pope BT, Buchowski MS
(2014) J Am Coll Nutr 33: 231-8
MeSH Terms: Adult, Basal Metabolism, Blood Pressure, Body Composition, Body Mass Index, C-Reactive Protein, Caloric Restriction, Cholesterol, HDL, Cholesterol, LDL, Diet, Reducing, Dietary Fiber, Double-Blind Method, F2-Isoprostanes, Female, Humans, Insulin, Leptin, Male, Middle Aged, Motor Activity, Obesity, Overweight, Patient Compliance, Phytosterols, Triglycerides, Weight Loss, Young Adult
Added July 30, 2015
0 Communities
1 Members
0 Resources
27 MeSH Terms
On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO.
Björkhem I, Diczfalusy U, Lövgren-Sandblom A, Starck L, Jonsson M, Tallman K, Schirmer H, Ousager LB, Crick PJ, Wang Y, Griffiths WJ, Guengerich FP
(2014) J Lipid Res 55: 1165-72
MeSH Terms: Adolescent, Adult, Child, Cholesterol 7-alpha-Hydroxylase, Dehydrocholesterols, Down-Regulation, Female, Gene Expression Regulation, Enzymologic, Humans, Ketocholesterols, Smith-Lemli-Opitz Syndrome, Xanthomatosis, Cerebrotendinous
Added May 26, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms