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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 15

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Structural analysis of lecithin:cholesterol acyltransferase bound to high density lipoprotein particles.
Manthei KA, Patra D, Wilson CJ, Fawaz MV, Piersimoni L, Shenkar JC, Yuan W, Andrews PC, Engen JR, Schwendeman A, Ohi MD, Tesmer JJG
(2020) Commun Biol 3: 28
MeSH Terms: Binding Sites, Catalytic Domain, Lipoproteins, HDL, Lysine, Mass Spectrometry, Models, Molecular, Multiprotein Complexes, Phosphatidylcholine-Sterol O-Acyltransferase, Protein Binding, Protein Conformation, Recombinant Proteins, Structure-Activity Relationship
Added March 3, 2020
0 Communities
1 Members
0 Resources
12 MeSH Terms
A thumbwheel mechanism for APOA1 activation of LCAT activity in HDL.
Cooke AL, Morris J, Melchior JT, Street SE, Jerome WG, Huang R, Herr AB, Smith LE, Segrest JP, Remaley AT, Shah AS, Thompson TB, Davidson WS
(2018) J Lipid Res 59: 1244-1255
MeSH Terms: Apolipoprotein A-I, Cholesterol, HDL, Enzyme Activation, Humans, Mutation, Phosphatidylcholine-Sterol O-Acyltransferase
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Low levels of high-density lipoprotein cholesterol due to lecithin:cholesterol acyltransferase mutations increase carotid atherosclerosis.
Fazio S, Linton MF
(2011) J Am Coll Cardiol 58: 2488-90
MeSH Terms: Atherosclerosis, Carotid Arteries, Carotid Artery Diseases, Female, Heterozygote, Humans, Magnetic Resonance Imaging, Male, Mutation, Phosphatidylcholine-Sterol O-Acyltransferase, Ultrasonography
Added December 10, 2013
0 Communities
2 Members
0 Resources
11 MeSH Terms
Failure of ACAT inhibition to retard atherosclerosis.
Fazio S, Linton M
(2006) N Engl J Med 354: 1307-9
MeSH Terms: Cholesterol, Coronary Artery Disease, Coronary Vessels, Disease Progression, Humans, Indoleacetic Acids, Sterol O-Acyltransferase, Treatment Failure, Ultrasonography, Interventional
Added May 27, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
ACAT1 deficiency increases cholesterol synthesis in mouse peritoneal macrophages.
Dove DE, Su YR, Swift LL, Linton MF, Fazio S
(2006) Atherosclerosis 186: 267-74
MeSH Terms: Animals, Biological Transport, Cells, Cultured, Cholesterol, Macrophages, Peritoneal, Mice, Mice, Inbred C57BL, Mice, Knockout, Phospholipids, Sterol O-Acyltransferase
Added December 10, 2013
0 Communities
3 Members
0 Resources
10 MeSH Terms
Acyl-coenzyme A:cholesterol acyltransferase promotes oxidized LDL/oxysterol-induced apoptosis in macrophages.
Freeman NE, Rusinol AE, Linton M, Hachey DL, Fazio S, Sinensky MS, Thewke D
(2005) J Lipid Res 46: 1933-43
MeSH Terms: Animals, Apoptosis, Arachidonic Acid, Carbon Radioisotopes, Caspase 3, Caspases, Cell Line, Cholesterol Esters, Enzyme Inhibitors, Esterification, In Situ Nick-End Labeling, Ketocholesterols, Lipoproteins, LDL, Macrophages, Macrophages, Peritoneal, Mice, Mice, Inbred C57BL, Phospholipases A, Phospholipases A2, Sterol O-Acyltransferase, Tritium
Added March 20, 2014
0 Communities
2 Members
0 Resources
21 MeSH Terms
Phytosterols and lecithin do not have an additive effect in lowering plasma and hepatic cholesterol levels in diet-induced hypercholesterolemic rats.
Shin J, Kim YJ, Choi MS, Woo DH, Park T
(2004) Biofactors 22: 173-5
MeSH Terms: Animals, Cholesterol, Dietary, Dietary Supplements, Hydroxymethylglutaryl CoA Reductases, Hypercholesterolemia, Male, Phosphatidylcholines, Phytosterols, Rats, Rats, Sprague-Dawley, Sterol O-Acyltransferase
Added March 3, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
ACAT inhibition: bad for macrophages, good for smooth muscle cells?
Fazio S, Dove DE, Linton MF
(2005) Arterioscler Thromb Vasc Biol 25: 7-9
MeSH Terms: Animals, Humans, Macrophages, Myocytes, Smooth Muscle, Sterol O-Acyltransferase
Added May 27, 2014
0 Communities
1 Members
0 Resources
5 MeSH Terms
ACAT1 deficiency disrupts cholesterol efflux and alters cellular morphology in macrophages.
Dove DE, Su YR, Zhang W, Jerome WG, Swift LL, Linton MF, Fazio S
(2005) Arterioscler Thromb Vasc Biol 25: 128-34
MeSH Terms: ATP Binding Cassette Transporter 1, ATP-Binding Cassette Transporters, Acetyl-CoA C-Acetyltransferase, Animals, Biological Transport, Active, Cholesterol, Cholesterol Esters, Cholesterol, LDL, Endosomes, Foam Cells, Lysosomes, Macrophages, Peritoneal, Mice, Microscopy, Electron, Transmission, Microscopy, Fluorescence, RNA, Messenger, Sterol O-Acyltransferase, Tritium
Added December 10, 2013
0 Communities
4 Members
0 Resources
18 MeSH Terms
Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages.
Fazio S, Major AS, Swift LL, Gleaves LA, Accad M, Linton MF, Farese RV
(2001) J Clin Invest 107: 163-71
MeSH Terms: Animals, Aorta, Arteriosclerosis, Bone Marrow Transplantation, Cell Transplantation, Cholesterol, Coloring Agents, Female, Immunohistochemistry, Liver, Macrophages, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptors, LDL, Sterol O-Acyltransferase, Up-Regulation
Added February 11, 2014
0 Communities
3 Members
0 Resources
18 MeSH Terms