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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 73

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Conformational selection dominates binding of steroids to human cytochrome P450 17A1.
Guengerich FP, Wilkey CJ, Glass SM, Reddish MJ
(2019) J Biol Chem 294: 10028-10041
MeSH Terms: 17-alpha-Hydroxypregnenolone, 17-alpha-Hydroxyprogesterone, Androstenes, Humans, Kinetics, Protein Conformation, Steroid 17-alpha-Hydroxylase, Substrate Specificity
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Inherent steroid 17α,20-lyase activity in defunct cytochrome P450 17A enzymes.
Gonzalez E, Johnson KM, Pallan PS, Phan TTN, Zhang W, Lei L, Wawrzak Z, Yoshimoto FK, Egli M, Guengerich FP
(2018) J Biol Chem 293: 541-556
MeSH Terms: Animals, Cytochrome P-450 Enzyme System, Humans, Hydroxysteroids, Protein Conformation, Steroid 17-alpha-Hydroxylase, Zebrafish
Added March 14, 2018
0 Communities
1 Members
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7 MeSH Terms
Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1.
Gonzalez E, Guengerich FP
(2017) J Biol Chem 292: 13168-13185
MeSH Terms: 17-alpha-Hydroxypregnenolone, Androstenedione, Animals, Binding Sites, Biocatalysis, Cytochrome P-450 Enzyme Inhibitors, Cytochromes b5, Dehydroepiandrosterone, Humans, Imidazoles, Kinetics, Ligands, Models, Molecular, NADPH-Ferrihemoprotein Reductase, Naphthalenes, Oxidation-Reduction, Pregnenolone, Progesterone, Protein Conformation, Rats, Recombinant Proteins, Stereoisomerism, Steroid 17-alpha-Hydroxylase
Added March 14, 2018
0 Communities
1 Members
0 Resources
23 MeSH Terms
Mechanism of 17α,20-Lyase and New Hydroxylation Reactions of Human Cytochrome P450 17A1: 18O LABELING AND OXYGEN SURROGATE EVIDENCE FOR A ROLE OF A PERFERRYL OXYGEN.
Yoshimoto FK, Gonzalez E, Auchus RJ, Guengerich FP
(2016) J Biol Chem 291: 17143-64
MeSH Terms: Humans, Hydroxylation, Isotope Labeling, Oxygen, Progesterone, Steroid 17-alpha-Hydroxylase
Added March 14, 2018
0 Communities
1 Members
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6 MeSH Terms
Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
Zeng C, Matsuda K, Jia WH, Chang J, Kweon SS, Xiang YB, Shin A, Jee SH, Kim DH, Zhang B, Cai Q, Guo X, Long J, Wang N, Courtney R, Pan ZZ, Wu C, Takahashi A, Shin MH, Matsuo K, Matsuda F, Gao YT, Oh JH, Kim S, Jung KJ, Ahn YO, Ren Z, Li HL, Wu J, Shi J, Wen W, Yang G, Li B, Ji BT, Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), Brenner H, Schoen RE, Küry S, Colorectal Transdisciplinary (CORECT) Study, Gruber SB, Schumacher FR, Stenzel SL, Colon Cancer Family Registry (CCFR), Casey G, Hopper JL, Jenkins MA, Kim HR, Jeong JY, Park JW, Tajima K, Cho SH, Kubo M, Shu XO, Lin D, Zeng YX, Zheng W
(2016) Gastroenterology 150: 1633-1645
MeSH Terms: Adult, Aged, Asian Continental Ancestry Group, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Case-Control Studies, Colorectal Neoplasms, Eukaryotic Initiation Factor-3, Female, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Qb-SNARE Proteins, Ribosomal Proteins, Risk Factors, Steroid 17-alpha-Hydroxylase, Suppressor of Cytokine Signaling Proteins, Young Adult
Added May 4, 2017
0 Communities
2 Members
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21 MeSH Terms
Structural and kinetic basis of steroid 17α,20-lyase activity in teleost fish cytochrome P450 17A1 and its absence in cytochrome P450 17A2.
Pallan PS, Nagy LD, Lei L, Gonzalez E, Kramlinger VM, Azumaya CM, Wawrzak Z, Waterman MR, Guengerich FP, Egli M
(2015) J Biol Chem 290: 3248-68
MeSH Terms: Amino Acid Sequence, Androstenes, Animals, Catalytic Domain, Kinetics, Molecular Docking Simulation, Molecular Sequence Data, Progesterone, Protein Binding, Steroid 17-alpha-Hydroxylase, Zebrafish, Zebrafish Proteins
Added January 20, 2015
0 Communities
2 Members
0 Resources
12 MeSH Terms
Molecular basis of 17α-hydroxylase/17,20-lyase deficiency.
Yanase T, Imai T, Simpson ER, Waterman MR
(1992) J Steroid Biochem Mol Biol 43: 973-9
MeSH Terms: Adrenal Hyperplasia, Congenital, Animals, COS Cells, Chlorocebus aethiops, Exons, Female, Humans, Male, Mutant Proteins, Recombinant Proteins, Steroid 17-alpha-Hydroxylase
Added February 12, 2015
0 Communities
1 Members
0 Resources
11 MeSH Terms
Comparison of cAMP-responsive DNA sequences and their binding proteins associated with expression of the bovine CYP17 and CYP11A and human CYP21B genes.
Waterman MR, Kagawa N, Zanger UM, Momoi K, Lund J, Simpson ER
(1992) J Steroid Biochem Mol Biol 43: 931-5
MeSH Terms: Adrenal Cortex, Animals, Cattle, Cholesterol Side-Chain Cleavage Enzyme, Cyclic AMP, Cyclic AMP Response Element-Binding Protein, Gene Expression Regulation, Enzymologic, Humans, Isoenzymes, Response Elements, Steroid 17-alpha-Hydroxylase, Steroid 21-Hydroxylase
Added February 12, 2015
0 Communities
1 Members
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12 MeSH Terms
Clinical, genetic, and enzymatic characterization of P450 oxidoreductase deficiency in four patients.
Sahakitrungruang T, Huang N, Tee MK, Agrawal V, Russell WE, Crock P, Murphy N, Migeon CJ, Miller WL
(2009) J Clin Endocrinol Metab 94: 4992-5000
MeSH Terms: Adolescent, Adult, Bone and Bones, Catalysis, Cytochromes c, DNA, Disorders of Sex Development, Escherichia coli, Female, Genetic Vectors, Genitalia, Hormones, Humans, Infant, Newborn, Infertility, Male, Mutation, NADP, NADPH-Ferrihemoprotein Reductase, Pregnancy, Steroid 17-alpha-Hydroxylase, Syndrome
Added May 5, 2016
0 Communities
1 Members
0 Resources
22 MeSH Terms
Steroid hormones and hormone-related genetic and lifestyle characteristics as risk factors for benign prostatic hyperplasia: review of epidemiologic literature.
Neuhouser ML, Kristal AR, Penson DF
(2004) Urology 64: 201-11
MeSH Terms: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase, Aged, Alcohol Drinking, Case-Control Studies, Cohort Studies, Comorbidity, Cross-Sectional Studies, Diet, Genetic Predisposition to Disease, Gonadal Steroid Hormones, Humans, Life Style, Male, Middle Aged, Motor Activity, Obesity, Prostatic Hyperplasia, Receptors, Androgen, Receptors, Calcitriol, Risk Factors, Smoking, Steroid 17-alpha-Hydroxylase, Trinucleotide Repeats, United States
Added March 5, 2014
0 Communities
1 Members
0 Resources
24 MeSH Terms