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Results: 1 to 10 of 184

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Further exploration of an N-aryl phenoxyethoxy pyridinone-based series of mGlu NAMs: Challenging SAR, enantiospecific activity and in vivo efficacy.
Yamada Y, Yohn SE, Gilliland K, Loch MT, Schulte ML, Rodriguez AL, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW
(2019) Bioorg Med Chem Lett 29: 2670-2674
MeSH Terms: Animals, Anti-Anxiety Agents, Antidepressive Agents, Dose-Response Relationship, Drug, Mice, Molecular Structure, Pyridones, Rats, Receptors, Metabotropic Glutamate, Stereoisomerism, Structure-Activity Relationship
Added March 3, 2020
0 Communities
1 Members
0 Resources
11 MeSH Terms
Absolute Configurations of Naturally Occurring [5]- and [3]-Ladderanoic Acids: Isolation, Chiroptical Spectroscopy, and Crystallography.
Raghavan V, Johnson JL, Stec DF, Song B, Zajac G, Baranska M, Harris CM, Schley ND, Polavarapu PL, Harris TM
(2018) J Nat Prod 81: 2654-2666
MeSH Terms: Biomass, Bioreactors, Circular Dichroism, Crystallography, X-Ray, Esters, Lipids, Molecular Conformation, Molecular Structure, Spectrum Analysis, Raman, Stereoisomerism
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Structural Characterization of Methylenedianiline Regioisomers by Ion Mobility-Mass Spectrometry and Tandem Mass Spectrometry. 4. 3-Ring and 4-Ring Isomers.
Crescentini TM, Stow SM, Forsythe JG, May JC, McLean JA, Hercules DM
(2018) Anal Chem 90: 14453-14461
MeSH Terms: Aniline Compounds, Ion Mobility Spectrometry, Stereoisomerism, Tandem Mass Spectrometry
Added December 17, 2018
1 Communities
1 Members
0 Resources
4 MeSH Terms
Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site.
Goodman MC, Xu S, Rouzer CA, Banerjee S, Ghebreselasie K, Migliore M, Piomelli D, Marnett LJ
(2018) J Biol Chem 293: 3028-3038
MeSH Terms: Amidohydrolases, Catalytic Domain, Cyclooxygenase Inhibitors, Isoenzymes, Phenylcarbamates, Phenylpropionates, Prostaglandin-Endoperoxide Synthases, Protein Binding, Stereoisomerism, Substrate Specificity
Added April 22, 2018
0 Communities
1 Members
0 Resources
10 MeSH Terms
Absolute configuration of an axially chiral sulfonate determined from its optical rotatory dispersion, electronic circular dichroism, and vibrational circular dichroism spectra.
Covington CL, Raghavan V, Smuts JP, Armstrong DW, Polavarapu PL
(2017) Chirality 29: 670-676
MeSH Terms: Circular Dichroism, Models, Molecular, Molecular Conformation, Naphthalenes, Optical Rotatory Dispersion, Stereoisomerism, Sulfonic Acids, Vibration
Added April 10, 2018
0 Communities
1 Members
0 Resources
8 MeSH Terms
Structural Characterization of Methylenedianiline Regioisomers by Ion Mobility-Mass Spectrometry, Tandem Mass Spectrometry, and Computational Strategies. 3. MALDI Spectra of 2-Ring Isomers.
Stow SM, Crescentini TM, Forsythe JG, May JC, McLean JA, Hercules DM
(2017) Anal Chem 89: 9900-9910
MeSH Terms: Aniline Compounds, Density Functional Theory, Ion Mobility Spectrometry, Mass Spectrometry, Molecular Dynamics Simulation, Molecular Structure, Stereoisomerism
Added December 17, 2018
0 Communities
1 Members
0 Resources
7 MeSH Terms
Human mitochondrial cytochrome P450 27C1 is localized in skin and preferentially desaturates -retinol to 3,4-dehydroretinol.
Johnson KM, Phan TTN, Albertolle ME, Guengerich FP
(2017) J Biol Chem 292: 13672-13687
MeSH Terms: Biocatalysis, Cytochrome P450 Family 27, Diterpenes, Gene Expression Profiling, Gene Expression Regulation, Enzymologic, Humans, Hydrogenation, Hydroxylation, Isoenzymes, Kinetics, Mitochondria, Molecular Structure, Organ Specificity, Oxidation-Reduction, Peptide Fragments, Proteolysis, Proteomics, Skin, Stereoisomerism, Substrate Specificity, Vitamin A
Added March 14, 2018
0 Communities
1 Members
0 Resources
21 MeSH Terms
Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1.
Gonzalez E, Guengerich FP
(2017) J Biol Chem 292: 13168-13185
MeSH Terms: 17-alpha-Hydroxypregnenolone, Androstenedione, Animals, Binding Sites, Biocatalysis, Cytochrome P-450 Enzyme Inhibitors, Cytochromes b5, Dehydroepiandrosterone, Humans, Imidazoles, Kinetics, Ligands, Models, Molecular, NADPH-Ferrihemoprotein Reductase, Naphthalenes, Oxidation-Reduction, Pregnenolone, Progesterone, Protein Conformation, Rats, Recombinant Proteins, Stereoisomerism, Steroid 17-alpha-Hydroxylase
Added March 14, 2018
0 Communities
1 Members
0 Resources
23 MeSH Terms
Atropoisomerism in Biflavones: The Absolute Configuration of (-)-Agathisflavone via Chiroptical Spectroscopy.
Covington CL, Junior FM, Silva JH, Kuster RM, de Amorim MB, Polavarapu PL
(2016) J Nat Prod 79: 2530-2537
MeSH Terms: Biflavonoids, Circular Dichroism, Molecular Conformation, Molecular Structure, Optical Rotatory Dispersion, Stereoisomerism
Added April 10, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Structural Analysis Using Chiroptical Spectroscopy: Insights and Cautions.
Polavarapu PL
(2016) Chirality 28: 445-52
MeSH Terms: Circular Dichroism, Hydrocarbons, Halogenated, Isoflurane, Models, Molecular, Molecular Structure, Pentanes, Quantum Theory, Spectrum Analysis, Raman, Stereoisomerism
Added April 10, 2018
0 Communities
1 Members
0 Resources
MeSH Terms