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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 17

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Human cytochrome P450 enzymes bind drugs and other substrates mainly through conformational-selection modes.
Guengerich FP, Wilkey CJ, Phan TTN
(2019) J Biol Chem 294: 10928-10941
MeSH Terms: Catalysis, Cytochrome P-450 CYP2D6, Cytochrome P-450 CYP2E1, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Humans, Kinetics, Lauric Acids, Ligands, Molecular Conformation, Oxidation-Reduction, Palmitic Acid, Protein Binding, Protein Conformation, Spiro Compounds, Substrate Specificity
Added March 3, 2020
0 Communities
1 Members
0 Resources
17 MeSH Terms
Mitochondrial Cyclophilin D in Vascular Oxidative Stress and Hypertension.
Itani HA, Dikalova AE, McMaster WG, Nazarewicz RR, Bikineyeva AT, Harrison DG, Dikalov SI
(2016) Hypertension 67: 1218-27
MeSH Terms: Analysis of Variance, Angiotensin II, Animals, Biomarkers, Cells, Cultured, Chromatography, High Pressure Liquid, Cyclophilin D, Cyclophilins, Disease Models, Animal, Endothelium, Vascular, Hypertension, Lactones, Male, Mice, Mice, Inbred C57BL, Mitochondria, Oxidative Stress, Random Allocation, Spiro Compounds, Superoxides, Vasodilation
Added April 26, 2016
0 Communities
2 Members
0 Resources
21 MeSH Terms
Quantitative Signaling and Structure-Activity Analyses Demonstrate Functional Selectivity at the Nociceptin/Orphanin FQ Opioid Receptor.
Chang SD, Mascarella SW, Spangler SM, Gurevich VV, Navarro HA, Carroll FI, Bruchas MR
(2015) Mol Pharmacol 88: 502-11
MeSH Terms: Acetates, Benzimidazoles, HEK293 Cells, Humans, Narcotic Antagonists, Piperidines, Protein Binding, Receptors, Opioid, Spiro Compounds, Structure-Activity Relationship
Added February 15, 2016
0 Communities
1 Members
0 Resources
10 MeSH Terms
Unraveling curcumin degradation: autoxidation proceeds through spiroepoxide and vinylether intermediates en route to the main bicyclopentadione.
Gordon ON, Luis PB, Sintim HO, Schneider C
(2015) J Biol Chem 290: 4817-4828
MeSH Terms: Curcumin, Magnetic Resonance Spectroscopy, Oxidation-Reduction, Oxygen Isotopes, Spiro Compounds
Added January 20, 2015
0 Communities
1 Members
0 Resources
5 MeSH Terms
Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane Core: discovery of Ml298 and Ml299 that decrease invasive migration in U87-MG glioblastoma cells.
O'Reilly MC, Scott SA, Brown KA, Oguin TH, Thomas PG, Daniels JS, Morrison R, Brown HA, Lindsley CW
(2013) J Med Chem 56: 2695-9
MeSH Terms: Benzamides, Cell Line, Tumor, Cell Movement, Drug Discovery, Enzyme Inhibitors, Glioblastoma, Humans, Neoplasm Invasiveness, Phospholipase D, Spiro Compounds
Added March 19, 2013
1 Communities
2 Members
0 Resources
10 MeSH Terms
Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe molecule.
Poslusney MS, Melancon BJ, Gentry PR, Sheffler DJ, Bridges TM, Utley TJ, Daniels JS, Niswender CM, Conn PJ, Lindsley CW, Wood MR
(2013) Bioorg Med Chem Lett 23: 1860-4
MeSH Terms: Allosteric Regulation, Animals, Humans, Isatin, Protein Binding, Pyrrolidines, Rats, Receptor, Muscarinic M1, Spiro Compounds, Structure-Activity Relationship
Added March 7, 2014
1 Communities
3 Members
0 Resources
10 MeSH Terms
Deoxyguanosine forms a bis-adduct with E,E-muconaldehyde, an oxidative metabolite of benzene: implications for the carcinogenicity of benzene.
Harris CM, Stec DF, Christov PP, Kozekov ID, Rizzo CJ, Harris TM
(2011) Chem Res Toxicol 24: 1944-56
MeSH Terms: Aldehydes, Amino Acids, Benzene, Biotransformation, Carcinogens, Circular Dichroism, DNA, DNA Adducts, Deoxyguanosine, Environmental Pollution, Humans, Magnetic Resonance Spectroscopy, Nucleic Acid Conformation, Oxidation-Reduction, Peptides, Solutions, Spiro Compounds, Stereoisomerism
Added March 7, 2014
0 Communities
2 Members
0 Resources
18 MeSH Terms
Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor.
Lavieri RR, Scott SA, Selvy PE, Kim K, Jadhav S, Morrison RD, Daniels JS, Brown HA, Lindsley CW
(2010) J Med Chem 53: 6706-19
MeSH Terms: Allosteric Regulation, Animals, Antineoplastic Agents, Apoptosis, Blood Proteins, Cell Line, Cell Line, Tumor, Cell Proliferation, Drug Design, Drug Screening Assays, Antitumor, Humans, Isoenzymes, Male, Microsomes, Liver, Naphthalenes, Phospholipase D, Protein Binding, Rats, Rats, Sprague-Dawley, Spiro Compounds, Stereoisomerism, Structure-Activity Relationship
Added March 19, 2013
0 Communities
1 Members
0 Resources
22 MeSH Terms
The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo.
Liu M, Bandaru V, Bond JP, Jaruga P, Zhao X, Christov PP, Burrows CJ, Rizzo CJ, Dizdaroglu M, Wallace SS
(2010) Proc Natl Acad Sci U S A 107: 4925-30
MeSH Terms: Amino Acid Sequence, Animals, DNA, DNA Damage, DNA Glycosylases, Endodeoxyribonucleases, Escherichia coli, Gamma Rays, Guanidines, Guanosine, Hydantoins, Kinetics, Mice, Molecular Sequence Data, Mutation, Pyrimidines, Schiff Bases, Sequence Alignment, Sequence Homology, Amino Acid, Spiro Compounds, Substrate Specificity, Valine
Added January 7, 2016
0 Communities
1 Members
0 Resources
22 MeSH Terms
Anabolic interventions in ESRD: light at the end of the tunnel?
Hakim RM, Ikizler TA
(2009) Am J Kidney Dis 54: 201-4
MeSH Terms: Ghrelin, Humans, Indoles, Kidney Failure, Chronic, Metabolic Diseases, Spiro Compounds
Added May 20, 2014
0 Communities
2 Members
0 Resources
6 MeSH Terms