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Measuring Speech Comprehensibility in Students with Down Syndrome.
Yoder PJ, Woynaroski T, Camarata S
(2016) J Speech Lang Hear Res 59: 460-7
MeSH Terms: Adolescent, Child, Comprehension, Down Syndrome, Humans, Observer Variation, Regression Analysis, Speech Disorders, Speech Intelligibility, Speech Production Measurement, Students, Video Recording
Show Abstract · Added March 18, 2020
PURPOSE - There is an ongoing need to develop assessments of spontaneous speech that focus on whether the child's utterances are comprehensible to listeners. This study sought to identify the attributes of a stable ratings-based measure of speech comprehensibility, which enabled examining the criterion-related validity of an orthography-based measure of the comprehensibility of conversational speech in students with Down syndrome.
METHOD - Participants were 10 elementary school students with Down syndrome and 4 unfamiliar adult raters. Averaged across-observer Likert ratings of speech comprehensibility were called a ratings-based measure of speech comprehensibility. The proportion of utterance attempts fully glossed constituted an orthography-based measure of speech comprehensibility.
RESULTS - Averaging across 4 raters on four 5-min segments produced a reliable (G = .83) ratings-based measure of speech comprehensibility. The ratings-based measure was strongly (r > .80) correlated with the orthography-based measure for both the same and different conversational samples.
CONCLUSION - Reliable and valid measures of speech comprehensibility are achievable with the resources available to many researchers and some clinicians.
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Vanderbilt Head and Neck Symptom Survey version 2.0: report of the development and initial testing of a subscale for assessment of oral health.
Cooperstein E, Gilbert J, Epstein JB, Dietrich MS, Bond SM, Ridner SH, Wells N, Cmelak A, Murphy BA
(2012) Head Neck 34: 797-804
MeSH Terms: Appetite, Chemoradiotherapy, Cohort Studies, Cross-Sectional Studies, Deglutition Disorders, Dentin Sensitivity, Dentures, Female, Head and Neck Neoplasms, Hearing Disorders, Humans, Jaw, Male, Middle Aged, Movement, Mucositis, Mucus, Neck, Olfaction Disorders, Oral Health, Pain, Radiotherapy, Range of Motion, Articular, Severity of Illness Index, Shoulder Joint, Speech Disorders, Surveys and Questionnaires, Tooth Injuries, Voice Disorders, Weight Loss, Xerostomia
Show Abstract · Added March 5, 2014
BACKGROUND - The prevalence, severity, and functional implications of adverse oral health outcomes attributed to head and neck cancer therapy are largely undefined. We report development of an oral health outcome subscale for the Vanderbilt Head and Neck Symptom Survey (VHNSS).
METHODS - Oral health outcome questions were formulated through literature review and consultation with an expert panel. Questions were incorporated into the VHNSS resulting in a 50-item survey, scored 0 (none) to 10 (severe). The tool was administered to 70 subjects who completed radiation to assess for feasibility.
RESULTS - Patient acceptance was high with a completion time <10 minutes. A full range of scores was noted for 46 of 50 questions. Oral health symptom burden was high early and late posttreatment.
CONCLUSIONS - The VHNSS version 2.0 was feasible and could be completed in a timely manner. Validation studies are ongoing. The high prevalence of adverse oral health outcomes warrants further study.
Copyright © 2011 Wiley Periodicals, Inc.
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31 MeSH Terms
Deep brain stimulation in early stage Parkinson's disease: operative experience from a prospective randomised clinical trial.
Kahn E, D'Haese PF, Dawant B, Allen L, Kao C, Charles PD, Konrad P
(2012) J Neurol Neurosurg Psychiatry 83: 164-70
MeSH Terms: Aged, Deep Brain Stimulation, Disease Progression, Electrodes, Implanted, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neurologic Examination, Neurosurgical Procedures, Parkinson Disease, Perioperative Period, Postoperative Complications, Prospective Studies, Retrospective Studies, Speech Disorders, Stroke, Subthalamic Nucleus
Show Abstract · Added April 10, 2018
BACKGROUND - Recent evidence suggests that deep brain stimulation of the subthalamic nucleus (STN-DBS) may have a disease modifying effect in early Parkinson's disease (PD). A randomised, prospective study is underway to determine whether STN-DBS in early PD is safe and tolerable.
OBJECTIVES/METHODS - 15 of 30 early PD patients were randomised to receive STN-DBS implants in an institutional review board approved protocol. Operative technique, location of DBS leads and perioperative adverse events are reported. Active contact used for stimulation in these patients was compared with 47 advanced PD patients undergoing an identical procedure by the same surgeon.
RESULTS - 14 of the 15 patients did not sustain any long term (>3 months) complications from the surgery. One subject suffered a stroke resulting in mild cognitive changes and slight right arm and face weakness. The average optimal contact used in symptomatic treatment of early PD patients was: anterior -1.1±1.7 mm, lateral 10.7±1.7 mm and superior -3.3±2.5 mm (anterior and posterior commissure coordinates). This location is statistically no different (0.77 mm, p>0.05) than the optimal contact used in the treatment of 47 advanced PD patients.
CONCLUSIONS - The perioperative adverse events in this trial of subjects with early stage PD are comparable with those reported for STN-DBS in advanced PD. The active contact position used in early PD is not significantly different from that used in late stage disease. This is the first report of the operative experience from a randomised, surgical versus best medical therapy trial for the early treatment of PD.
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Genetic aspects of early childhood stuttering.
Ambrose NG, Yairi E, Cox N
(1993) J Speech Hear Res 36: 701-6
MeSH Terms: Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Pedigree, Sex Factors, Speech, Speech Disorders, Speech Production Measurement, Stuttering
Show Abstract · Added February 22, 2016
Although stuttering has long been acknowledged as a familial disorder, the nature of a genetic component remains unclear. Most previous data used in genetic studies were obtained primarily from adults who stutter and may be biased in several respects. The purpose of this investigation was to quantify the frequency of stuttering in relatives of preschool-age children who stutter, and who were first seen close to the onset of the disorder. Detailed pedigrees (family trees), including first-, second-, and third-degree relatives, were obtained from parents of 69 children who stuttered. We found, as have previous studies, that more male than female relatives ever stuttered, but that female subjects who stuttered had more female relatives who ever stuttered than did male subjects. In order to identify the genetic model most consistent with the observed patterns of stuttering transmission, we conducted segregation analyses. Results from these analyses suggest that transmission of a single major genetic locus increasing the liability to stuttering best accounts for the transmission of stuttering in families of preschool-age children who stutter.
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13 MeSH Terms
Segregation analysis of speech and language disorders.
Lewis BA, Cox NJ, Byard PJ
(1993) Behav Genet 23: 291-7
MeSH Terms: Adolescent, Adult, Child, Child, Preschool, Dyslexia, Female, Humans, Language Development Disorders, Male, Models, Genetic, Phenotype, Risk Factors, Speech Disorders
Show Abstract · Added February 22, 2016
Complex segregation analysis was performed on pedigrees ascertained through 45 probands (26 males, 19 females) with a history of preschool speech and language disorders. Hypotheses concerning mode of inheritance were tested using the POINTER segregation analysis program. Although there is strong evidence for familial transmission of this trait, we were unable to distinguish between a major gene and multifactorial transmission model using likelihood-ratio chi-square tests. Future studies with quantitative measures of speech and language disorders are needed to resolve the issue of mode of inheritance for this trait.
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13 MeSH Terms
Two patients with ring chromosome 15 syndrome.
Butler MG, Fogo AB, Fuchs DA, Collins FS, Dev VG, Phillips JA
(1988) Am J Med Genet 29: 149-54
MeSH Terms: Abnormalities, Multiple, Child, Child, Preschool, Chromosome Aberrations, Chromosomes, Human, Pair 15, Female, Growth Disorders, Humans, Intellectual Disability, Male, Microcephaly, Ring Chromosomes, Speech Disorders, Syndrome
Show Abstract · Added January 20, 2012
We report on 2 patients (3 1/2 year-old-male and 6-year-old female) with the ring 15 chromosome syndrome and speech delays and review 25 cases from the literature. The main characteristics of this syndrome include growth retardation (100%), variable mental retardation (95%), microcephaly (88%), hypertelorism (46%), and triangular facies (42%). Other frequent findings include delayed bone age (75%), brachydactyly (44%), speech delay (39%), frontal bossing (36%), anomalous ears (30%), café-au-lait spots (30%), cryptorchidism (30%), and cardiac abnormalities (30%). The average age at diagnosis was 8.1 years. The average maternal and paternal age at the time of birth was 28 and 31 years, respectively.
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14 MeSH Terms