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Structural basis for delta cell paracrine regulation in pancreatic islets.
Arrojo E Drigo R, Jacob S, García-Prieto CF, Zheng X, Fukuda M, Nhu HTT, Stelmashenko O, Peçanha FLM, Rodriguez-Diaz R, Bushong E, Deerinck T, Phan S, Ali Y, Leibiger I, Chua M, Boudier T, Song SH, Graf M, Augustine GJ, Ellisman MH, Berggren PO
(2019) Nat Commun 10: 3700
MeSH Terms: Animals, Blood Glucose, Humans, Insulin-Like Growth Factor I, Insulin-Secreting Cells, Intravital Microscopy, Islets of Langerhans, Mice, Mice, Transgenic, Microscopy, Electron, Optical Imaging, Optogenetics, Paracrine Communication, Prediabetic State, Pseudopodia, Somatostatin-Secreting Cells, Vascular Endothelial Growth Factor A
Added April 14, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion.
Vierra NC, Dickerson MT, Jordan KL, Dadi PK, Katdare KA, Altman MK, Milian SC, Jacobson DA
(2018) Mol Metab 9: 84-97
MeSH Terms: Animals, Calcium Signaling, Cells, Cultured, Cytoplasm, Endoplasmic Reticulum, Glucagon, Humans, Male, Mice, Mice, Inbred C57BL, Potassium Channels, Tandem Pore Domain, Somatostatin, Somatostatin-Secreting Cells
Added February 7, 2018
0 Communities
1 Members
0 Resources
13 MeSH Terms
Inactivating the permanent neonatal diabetes gene Mnx1 switches insulin-producing β-cells to a δ-like fate and reveals a facultative proliferative capacity in aged β-cells.
Pan FC, Brissova M, Powers AC, Pfaff S, Wright CV
(2015) Development 142: 3637-48
MeSH Terms: Animals, Cell Transdifferentiation, Cellular Senescence, Diabetes Mellitus, Eye Proteins, Homeodomain Proteins, Humans, Hyperplasia, Insulin-Secreting Cells, Mice, PAX6 Transcription Factor, Paired Box Transcription Factors, Repressor Proteins, Somatostatin-Secreting Cells, Transcription Factors
Added December 28, 2015
0 Communities
3 Members
0 Resources
15 MeSH Terms
Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets.
Blodgett DM, Nowosielska A, Afik S, Pechhold S, Cura AJ, Kennedy NJ, Kim S, Kucukural A, Davis RJ, Kent SC, Greiner DL, Garber MG, Harlan DM, diIorio P
(2015) Diabetes 64: 3172-81
MeSH Terms: Adolescent, Adult, Child, Preschool, Female, Fetus, Gene Expression Profiling, Gene Expression Regulation, Developmental, Glucagon-Secreting Cells, Humans, Insulin-Secreting Cells, Islets of Langerhans, Male, Middle Aged, Pregnancy, Pregnancy Trimester, Second, RNA, Sequence Analysis, RNA, Somatostatin-Secreting Cells, Young Adult
Added October 12, 2016
0 Communities
1 Members
0 Resources
19 MeSH Terms
Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers.
Chera S, Baronnier D, Ghila L, Cigliola V, Jensen JN, Gu G, Furuyama K, Thorel F, Gribble FM, Reimann F, Herrera PL
(2014) Nature 514: 503-7
MeSH Terms: Aging, Animals, Cell Dedifferentiation, Cell Proliferation, Cell Transdifferentiation, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 1, Forkhead Box Protein O1, Forkhead Transcription Factors, Glucagon-Secreting Cells, Humans, Insulin, Insulin Secretion, Insulin-Secreting Cells, Mice, Regeneration, Sexual Maturation, Somatostatin, Somatostatin-Secreting Cells
Added October 15, 2015
1 Communities
1 Members
0 Resources
19 MeSH Terms
Loss of Fbw7 reprograms adult pancreatic ductal cells into α, δ, and β cells.
Sancho R, Gruber R, Gu G, Behrens A
(2014) Cell Stem Cell 15: 139-53
MeSH Terms: Animals, Basic Helix-Loop-Helix Transcription Factors, Cell Differentiation, Cell Line, Tumor, Cell Lineage, F-Box Proteins, F-Box-WD Repeat-Containing Protein 7, Gene Deletion, Gene Expression Profiling, Gene Expression Regulation, Developmental, Glucagon-Secreting Cells, Glucose, HEK293 Cells, Humans, Insulin, Insulin Secretion, Insulin-Secreting Cells, Mice, Multipotent Stem Cells, Nerve Tissue Proteins, Pancreatic Ducts, Proteasome Endopeptidase Complex, Regeneration, Somatostatin-Secreting Cells, Ubiquitin-Protein Ligases, Ubiquitination
Added January 23, 2015
1 Communities
1 Members
0 Resources
26 MeSH Terms
Islet α-, β-, and δ-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor.
Hunter CS, Dixit S, Cohen T, Ediger B, Wilcox C, Ferreira M, Westphal H, Stein R, May CL
(2013) Diabetes 62: 875-86
MeSH Terms: Animals, Cell Nucleus, DNA-Binding Proteins, Female, Gene Expression Regulation, Glucagon-Secreting Cells, Insulin-Secreting Cells, Islets of Langerhans, LIM Domain Proteins, LIM-Homeodomain Proteins, Male, Mice, Mice, Knockout, Mice, Mutant Strains, Mice, Transgenic, Organ Specificity, Organogenesis, Protein Isoforms, RNA, Messenger, Somatostatin-Secreting Cells, Transcription Factors
Added December 5, 2013
1 Communities
1 Members
0 Resources
21 MeSH Terms
The hypothalamic satiety peptide CART is expressed in anorectic and non-anorectic pancreatic islet tumors and in the normal islet of Langerhans.
Jensen PB, Kristensen P, Clausen JT, Judge ME, Hastrup S, Thim L, Wulff BS, Foged C, Jensen J, Holst JJ, Madsen OD
(1999) FEBS Lett 447: 139-43
MeSH Terms: Adenoma, Islet Cell, Animals, Anorexia, Base Sequence, DNA Probes, Eating, Female, Gene Expression, Glucagonoma, Immunohistochemistry, In Situ Hybridization, Insulinoma, Islets of Langerhans, Nerve Tissue Proteins, Pancreatic Neoplasms, RNA, Messenger, RNA, Neoplasm, Rats, Somatostatin-Secreting Cells
Added August 18, 2010
0 Communities
0 Members
2 Resources
19 MeSH Terms