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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 5 of 5

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Contribution of hepatic organic anion-transporting polypeptides to docetaxel uptake and clearance.
Lee HH, Leake BF, Teft W, Tirona RG, Kim RB, Ho RH
(2015) Mol Cancer Ther 14: 994-1003
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Member 1, Animals, Antineoplastic Agents, Biological Transport, Cell Line, Tumor, Docetaxel, Humans, Liver, Liver-Specific Organic Anion Transporter 1, Male, Mice, Mice, Knockout, Organic Anion Transporters, Organic Anion Transporters, Sodium-Independent, Rats, Solute Carrier Organic Anion Transporter Family Member 1B3, Taxoids, Tubulin Modulators
Added February 25, 2015
0 Communities
2 Members
0 Resources
18 MeSH Terms
A cancer-specific variant of the SLCO1B3 gene encodes a novel human organic anion transporting polypeptide 1B3 (OATP1B3) localized mainly in the cytoplasm of colon and pancreatic cancer cells.
Thakkar N, Kim K, Jang ER, Han S, Kim K, Kim D, Merchant N, Lockhart AC, Lee W
(2013) Mol Pharm 10: 406-16
MeSH Terms: Biological Transport, Cell Line, Tumor, Colonic Neoplasms, Cytoplasm, Exons, Genetic Variation, HCT116 Cells, Humans, Liver, Organic Anion Transporters, Sodium-Independent, Pancreatic Neoplasms, Protein Processing, Post-Translational, Sincalide, Solute Carrier Organic Anion Transporter Family Member 1B3
Added March 26, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Interaction of three regiospecific amino acid residues is required for OATP1B1 gain of OATP1B3 substrate specificity.
DeGorter MK, Ho RH, Leake BF, Tirona RG, Kim RB
(2012) Mol Pharm 9: 986-95
MeSH Terms: Amino Acids, Cholecystokinin, Liver-Specific Organic Anion Transporter 1, Mutagenesis, Site-Directed, Organic Anion Transporters, Organic Anion Transporters, Sodium-Independent, Peptide Fragments, Solute Carrier Organic Anion Transporter Family Member 1B3, Substrate Specificity
Added March 5, 2014
2 Communities
2 Members
2 Resources
9 MeSH Terms
Identification of novel functional organic anion-transporting polypeptide 1B3 polymorphisms and assessment of substrate specificity.
Schwarz UI, Meyer zu Schwabedissen HE, Tirona RG, Suzuki A, Leake BF, Mokrab Y, Mizuguchi K, Ho RH, Kim RB
(2011) Pharmacogenet Genomics 21: 103-14
MeSH Terms: Amino Acid Sequence, Amino Acid Substitution, Atorvastatin, Fluorobenzenes, Gene Expression, HeLa Cells, Heptanoic Acids, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Liver, Molecular Sequence Data, Mutagenesis, Site-Directed, Organic Anion Transporters, Sodium-Independent, Polymorphism, Genetic, Protein Conformation, Pyrimidines, Pyrroles, Rosuvastatin Calcium, Sincalide, Solute Carrier Organic Anion Transporter Family Member 1B3, Structure-Activity Relationship, Substrate Specificity, Sulfonamides
Added March 5, 2014
2 Communities
2 Members
2 Resources
23 MeSH Terms
Overexpression of OATP1B3 confers apoptotic resistance in colon cancer.
Lee W, Belkhiri A, Lockhart AC, Merchant N, Glaeser H, Harris EI, Washington MK, Brunt EM, Zaika A, Kim RB, El-Rifai W
(2008) Cancer Res 68: 10315-23
MeSH Terms: Adenocarcinoma, Apoptosis, Caco-2 Cells, Cell Line, Tumor, Colorectal Neoplasms, HCT116 Cells, Humans, Immunohistochemistry, Organic Anion Transporters, Sodium-Independent, RNA, Messenger, Solute Carrier Organic Anion Transporter Family Member 1B3, Transcription, Genetic, Tumor Suppressor Protein p53
Added March 5, 2014
0 Communities
4 Members
0 Resources
13 MeSH Terms