Constitutively Active SPAK Causes Hyperkalemia by Activating NCC and Remodeling Distal Tubules.
Grimm PR, Coleman R, Delpire E, Welling PA
(2017) J Am Soc Nephrol 28
: 2597-2606MeSH Terms: Aldosterone, Animals, Blood Pressure, Epithelial Sodium Channels, Hydrochlorothiazide, Kidney Tubules, Distal, Mice, Natriuresis, Phosphorylation, Potassium, Potassium Channels, Inwardly Rectifying, Protein-Serine-Threonine Kinases, Pseudohypoaldosteronism, Signal Transduction, Sodium Chloride Symporter Inhibitors, Solute Carrier Family 12, Member 3Added May 3, 2017
16 MeSH Terms
20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: NORMALIZATION OF BLOOD PRESSURE BY SODIUM RESTRICTION, HYDROCHLOROTHIAZIDE, OR BLOCKADE OF THE TYPE 1 ANGIOTENSIN II RECEPTOR.
Savas Ü, Wei S, Hsu MH, Falck JR, Guengerich FP, Capdevila JH, Johnson EF
(2016) J Biol Chem 291
: 16904-19MeSH Terms: Angiotensins, Animals, Blood Pressure, Cytochrome P-450 CYP4A, Female, Humans, Hydroxyeicosatetraenoic Acids, Hypertension, Losartan, Male, Mice, Mice, Inbred BALB C, Mice, Transgenic, Receptor, Angiotensin, Type 1, Renin-Angiotensin System, Sodium Chloride, Dietary, Solute Carrier Family 12, Member 3Added March 14, 2018
17 MeSH Terms
Interleukin-17A Regulates Renal Sodium Transporters and Renal Injury in Angiotensin II-Induced Hypertension.
Norlander AE, Saleh MA, Kamat NV, Ko B, Gnecco J, Zhu L, Dale BL, Iwakura Y, Hoover RS, McDonough AA, Madhur MS
(2016) Hypertension 68
: 167-74MeSH Terms: Acute Kidney Injury, Analysis of Variance, Angiotensin II, Animals, Blood Pressure Determination, Cells, Cultured, Disease Models, Animal, Hypertension, Immunoblotting, Interleukin-17, Kidney Tubules, Proximal, Male, Mice, Mice, Inbred C57BL, Random Allocation, Real-Time Polymerase Chain Reaction, Sensitivity and Specificity, Sodium Chloride Symporters, Solute Carrier Family 12, Member 3Added September 7, 2017
19 MeSH Terms
Integrated compensatory network is activated in the absence of NCC phosphorylation.
Grimm PR, Lazo-Fernandez Y, Delpire E, Wall SM, Dorsey SG, Weinman EJ, Coleman R, Wade JB, Welling PA
(2015) J Clin Invest 125
: 2136-50MeSH Terms: Amiloride, Ammonia, Animals, Biological Transport, Blood Pressure, Carbonic Anhydrases, Chlorides, Disease Models, Animal, Enzyme Activation, Epithelial Sodium Channels, Gene Expression Profiling, Gene Regulatory Networks, Gitelman Syndrome, Ketoglutaric Acids, Kidney Glomerulus, Male, Mice, Mice, Knockout, Natriuresis, Nephrons, Paracrine Communication, Phosphorylation, Protein Processing, Post-Translational, Protein-Serine-Threonine Kinases, Receptors, Notch, Receptors, Purinergic P2, Renal Reabsorption, Signal Transduction, Sodium Chloride, Sodium-Potassium-Chloride Symporters, Solute Carrier Family 12, Member 3Added May 3, 2017
31 MeSH Terms
SPAK-mediated NCC regulation in response to low-K+ diet.
Wade JB, Liu J, Coleman R, Grimm PR, Delpire E, Welling PA
(2015) Am J Physiol Renal Physiol 308
: F923-31MeSH Terms: Animals, Kidney Tubules, Distal, Mice, Knockout, Phosphorylation, Potassium Deficiency, Potassium, Dietary, Protein-Serine-Threonine Kinases, Signal Transduction, Solute Carrier Family 12, Member 3, Up-RegulationAdded April 24, 2015
10 MeSH Terms
Intrarenal dopamine deficiency leads to hypertension and decreased longevity in mice.
Zhang MZ, Yao B, Wang S, Fan X, Wu G, Yang H, Yin H, Yang S, Harris RC
(2011) J Clin Invest 121
: 2845-54MeSH Terms: Aldosterone, Animals, Aquaporin 2, Aromatic-L-Amino-Acid Decarboxylases, Cyclooxygenase 2, Dopamine, Hypertension, Kidney, Kidney Tubules, Proximal, Longevity, Mice, Mice, Knockout, Receptors, Drug, Renin, Sodium-Bicarbonate Symporters, Sodium-Hydrogen Exchanger 3, Sodium-Hydrogen Exchangers, Sodium-Potassium-Chloride Symporters, Solute Carrier Family 12, Member 1, Solute Carrier Family 12, Member 3, SymportersAdded December 10, 2013
21 MeSH Terms