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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 6 of 6

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Constitutively Active SPAK Causes Hyperkalemia by Activating NCC and Remodeling Distal Tubules.
Grimm PR, Coleman R, Delpire E, Welling PA
(2017) J Am Soc Nephrol 28: 2597-2606
MeSH Terms: Aldosterone, Animals, Blood Pressure, Epithelial Sodium Channels, Hydrochlorothiazide, Kidney Tubules, Distal, Mice, Natriuresis, Phosphorylation, Potassium, Potassium Channels, Inwardly Rectifying, Protein-Serine-Threonine Kinases, Pseudohypoaldosteronism, Signal Transduction, Sodium Chloride Symporter Inhibitors, Solute Carrier Family 12, Member 3
Added May 3, 2017
0 Communities
1 Members
0 Resources
16 MeSH Terms
20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: NORMALIZATION OF BLOOD PRESSURE BY SODIUM RESTRICTION, HYDROCHLOROTHIAZIDE, OR BLOCKADE OF THE TYPE 1 ANGIOTENSIN II RECEPTOR.
Savas Ü, Wei S, Hsu MH, Falck JR, Guengerich FP, Capdevila JH, Johnson EF
(2016) J Biol Chem 291: 16904-19
MeSH Terms: Angiotensins, Animals, Blood Pressure, Cytochrome P-450 CYP4A, Female, Humans, Hydroxyeicosatetraenoic Acids, Hypertension, Losartan, Male, Mice, Mice, Inbred BALB C, Mice, Transgenic, Receptor, Angiotensin, Type 1, Renin-Angiotensin System, Sodium Chloride, Dietary, Solute Carrier Family 12, Member 3
Added March 14, 2018
0 Communities
2 Members
0 Resources
17 MeSH Terms
Interleukin-17A Regulates Renal Sodium Transporters and Renal Injury in Angiotensin II-Induced Hypertension.
Norlander AE, Saleh MA, Kamat NV, Ko B, Gnecco J, Zhu L, Dale BL, Iwakura Y, Hoover RS, McDonough AA, Madhur MS
(2016) Hypertension 68: 167-74
MeSH Terms: Acute Kidney Injury, Analysis of Variance, Angiotensin II, Animals, Blood Pressure Determination, Cells, Cultured, Disease Models, Animal, Hypertension, Immunoblotting, Interleukin-17, Kidney Tubules, Proximal, Male, Mice, Mice, Inbred C57BL, Random Allocation, Real-Time Polymerase Chain Reaction, Sensitivity and Specificity, Sodium Chloride Symporters, Solute Carrier Family 12, Member 3
Added September 7, 2017
1 Communities
1 Members
0 Resources
19 MeSH Terms
Integrated compensatory network is activated in the absence of NCC phosphorylation.
Grimm PR, Lazo-Fernandez Y, Delpire E, Wall SM, Dorsey SG, Weinman EJ, Coleman R, Wade JB, Welling PA
(2015) J Clin Invest 125: 2136-50
MeSH Terms: Amiloride, Ammonia, Animals, Biological Transport, Blood Pressure, Carbonic Anhydrases, Chlorides, Disease Models, Animal, Enzyme Activation, Epithelial Sodium Channels, Gene Expression Profiling, Gene Regulatory Networks, Gitelman Syndrome, Ketoglutaric Acids, Kidney Glomerulus, Male, Mice, Mice, Knockout, Natriuresis, Nephrons, Paracrine Communication, Phosphorylation, Protein Processing, Post-Translational, Protein-Serine-Threonine Kinases, Receptors, Notch, Receptors, Purinergic P2, Renal Reabsorption, Signal Transduction, Sodium Chloride, Sodium-Potassium-Chloride Symporters, Solute Carrier Family 12, Member 3
Added May 3, 2017
0 Communities
1 Members
0 Resources
31 MeSH Terms
SPAK-mediated NCC regulation in response to low-K+ diet.
Wade JB, Liu J, Coleman R, Grimm PR, Delpire E, Welling PA
(2015) Am J Physiol Renal Physiol 308: F923-31
MeSH Terms: Animals, Kidney Tubules, Distal, Mice, Knockout, Phosphorylation, Potassium Deficiency, Potassium, Dietary, Protein-Serine-Threonine Kinases, Signal Transduction, Solute Carrier Family 12, Member 3, Up-Regulation
Added April 24, 2015
1 Communities
0 Members
0 Resources
10 MeSH Terms
Intrarenal dopamine deficiency leads to hypertension and decreased longevity in mice.
Zhang MZ, Yao B, Wang S, Fan X, Wu G, Yang H, Yin H, Yang S, Harris RC
(2011) J Clin Invest 121: 2845-54
MeSH Terms: Aldosterone, Animals, Aquaporin 2, Aromatic-L-Amino-Acid Decarboxylases, Cyclooxygenase 2, Dopamine, Hypertension, Kidney, Kidney Tubules, Proximal, Longevity, Mice, Mice, Knockout, Receptors, Drug, Renin, Sodium-Bicarbonate Symporters, Sodium-Hydrogen Exchanger 3, Sodium-Hydrogen Exchangers, Sodium-Potassium-Chloride Symporters, Solute Carrier Family 12, Member 1, Solute Carrier Family 12, Member 3, Symporters
Added December 10, 2013
1 Communities
2 Members
0 Resources
21 MeSH Terms