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Results: 1 to 10 of 102

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Probing biophysical sequence constraints within the transmembrane domains of rhodopsin by deep mutational scanning.
Penn WD, McKee AG, Kuntz CP, Woods H, Nash V, Gruenhagen TC, Roushar FJ, Chandak M, Hemmerich C, Rusch DB, Meiler J, Schlebach JP
(2020) Sci Adv 6: eaay7505
MeSH Terms: Cell Membrane, Gene Expression, HEK293 Cells, Humans, Hydrophobic and Hydrophilic Interactions, Lipid Bilayers, Models, Molecular, Mutation, Protein Domains, Protein Folding, Protein Structure, Secondary, Recombinant Proteins, Rhodopsin, Solubility, Thermodynamics
Added March 21, 2020
0 Communities
1 Members
0 Resources
15 MeSH Terms
Editorial Comment.
Hsi RS
(2019) J Urol 201: 356
MeSH Terms: Humans, Kidney Calculi, Prospective Studies, Solubility
Added February 26, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients.
Schonhoft JD, Monteiro C, Plate L, Eisele YS, Kelly JM, Boland D, Parker CG, Cravatt BF, Teruya S, Helmke S, Maurer M, Berk J, Sekijima Y, Novais M, Coelho T, Powers ET, Kelly JW
(2017) Sci Transl Med 9:
MeSH Terms: Amyloidosis, Familial, Benzoxazoles, Case-Control Studies, Cross-Linking Reagents, Diazomethane, Genotype, Humans, Ions, Light, Molecular Probes, Molecular Weight, Peptides, Prealbumin, Protein Folding, Protein Multimerization, Protein Structure, Secondary, Proteolysis, Proteomics, Solubility
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
A pH-Mediated Topological Switch within the N-Terminal Domain of Human Caveolin-3.
Kim JH, Schlebach JP, Lu Z, Peng D, Reasoner KC, Sanders CR
(2016) Biophys J 110: 2475-2485
MeSH Terms: Amino Acid Sequence, Caveolin 3, Circular Dichroism, Humans, Hydrogen-Ion Concentration, Membranes, Artificial, Micelles, Models, Molecular, Mutation, Nuclear Magnetic Resonance, Biomolecular, Phosphatidylglycerols, Protein Structure, Secondary, Solubility, Solutions
Added November 21, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design.
Kwon YD, Georgiev IS, Ofek G, Zhang B, Asokan M, Bailer RT, Bao A, Caruso W, Chen X, Choe M, Druz A, Ko SY, Louder MK, McKee K, O'Dell S, Pegu A, Rudicell RS, Shi W, Wang K, Yang Y, Alger M, Bender MF, Carlton K, Cooper JW, Blinn J, Eudailey J, Lloyd K, Parks R, Alam SM, Haynes BF, Padte NN, Yu J, Ho DD, Huang J, Connors M, Schwartz RM, Mascola JR, Kwong PD
(2016) J Virol 90: 5899-5914
MeSH Terms: Animals, Antibodies, Neutralizing, Chemistry Techniques, Analytical, Crystallography, X-Ray, Disulfides, HIV Antibodies, HIV-1, Half-Life, High-Throughput Nucleotide Sequencing, Humans, Hydrophobic and Hydrophilic Interactions, Macaca mulatta, Models, Molecular, Solubility
Added May 3, 2017
0 Communities
1 Members
0 Resources
14 MeSH Terms
Growth phase-dependent composition of the Helicobacter pylori exoproteome.
Snider CA, Voss BJ, McDonald WH, Cover TL
(2016) J Proteomics 130: 94-107
MeSH Terms: Bacterial Proteins, Cluster Analysis, Gastritis, Gene Expression Regulation, Bacterial, Helicobacter Infections, Helicobacter pylori, Humans, Mass Spectrometry, Protein Sorting Signals, Proteome, Proteomics, Solubility, Stomach
Added October 8, 2015
0 Communities
2 Members
0 Resources
13 MeSH Terms
Dual drug delivery of tamoxifen and quercetin: Regulated metabolism for anticancer treatment with nanosponges.
Lockhart JN, Stevens DM, Beezer DB, Kravitz A, Harth E
(2015) J Control Release 220: 751-7
MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Biological Availability, Biotransformation, Breast Neoplasms, Cell Line, Tumor, Cell Survival, Chemistry, Pharmaceutical, Cross-Linking Reagents, Cytochrome P-450 CYP3A, Delayed-Action Preparations, Dose-Response Relationship, Drug, Drug Carriers, Drug Stability, Female, Gastric Juice, Glucuronosyltransferase, Intestinal Secretions, Kinetics, Mice, Nanomedicine, Nanoparticles, Particle Size, Polyesters, Quercetin, Solubility, Tamoxifen
Added February 15, 2016
0 Communities
1 Members
0 Resources
27 MeSH Terms
nido-Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase-2.
Neumann W, Xu S, Sárosi MB, Scholz MS, Crews BC, Ghebreselasie K, Banerjee S, Marnett LJ, Hey-Hawkins E
(2016) ChemMedChem 11: 175-8
MeSH Terms: Animals, Binding Sites, Boranes, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors, Dose-Response Relationship, Drug, Indomethacin, Mice, Models, Molecular, Molecular Structure, Sheep, Solubility, Structure-Activity Relationship
Added February 22, 2016
0 Communities
2 Members
0 Resources
13 MeSH Terms
Irreversible catalyst activation enables hyperpolarization and water solubility for NMR signal amplification by reversible exchange.
Truong ML, Shi F, He P, Yuan B, Plunkett KN, Coffey AM, Shchepin RV, Barskiy DA, Kovtunov KV, Koptyug IV, Waddell KW, Goodson BM, Chekmenev EY
(2014) J Phys Chem B 118: 13882-9
MeSH Terms: Catalysis, Coordination Complexes, Hydrogen, Hydrogenation, Iridium, Magnetic Resonance Spectroscopy, Niacinamide, Pyridines, Solubility, Water
Added February 13, 2015
0 Communities
1 Members
0 Resources
10 MeSH Terms
Current progress in Reactive Oxygen Species (ROS)-Responsive materials for biomedical applications.
Lee SH, Gupta MK, Bang JB, Bae H, Sung HJ
(2013) Adv Healthc Mater 2: 908-15
MeSH Terms: Animals, Biocompatible Materials, Reactive Oxygen Species, Solubility
Added February 12, 2015
0 Communities
1 Members
0 Resources
4 MeSH Terms