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Importance of SPECT/CT images in a case to differentiate a chest wall soft tissue infection from pneumonia on 111In-tagged WBC scintigraphy.
Bhojwani N, Hartman J, Mehta L
(2014) Clin Nucl Med 39: 561-3
MeSH Terms: Diagnosis, Differential, Humans, Indium Radioisotopes, Leukocyte Count, Male, Middle Aged, Multimodal Imaging, Pneumonia, Soft Tissue Infections, Thoracic Wall, Tomography, Emission-Computed, Single-Photon, Tomography, X-Ray Computed
Show Abstract · Added January 1, 2016
A 52-year-old man presented to the emergency department with a 3-day history of fevers and left flank pain radiating to the chest and neck. Total WBC count was 20,000/uL. Abdominal CT demonstrated small bibasilar pleural effusions. Because of persistent leukocytosis, an In WBC scintigram was ordered 5 days after admission, which demonstrated thoracic WBC accumulation on the planar images that localized to the left posterior chest wall on SPECT/CT. SPECT/CT may differentiate intrathoracic versus extrathoracic disease.
0 Communities
1 Members
0 Resources
12 MeSH Terms
Pro-angiogenic and anti-inflammatory regulation by functional peptides loaded in polymeric implants for soft tissue regeneration.
Zachman AL, Crowder SW, Ortiz O, Zienkiewicz KJ, Bronikowski CM, Yu SS, Giorgio TD, Guelcher SA, Kohn J, Sung HJ
(2013) Tissue Eng Part A 19: 437-47
MeSH Terms: Angiogenic Proteins, Animals, Anti-Inflammatory Agents, Drug Implants, Equipment Design, Guided Tissue Regeneration, Laminin, Mice, Peptides, Polyethylenes, Regeneration, Soft Tissue Infections, Thymosin, Tissue Scaffolds, Treatment Outcome
Show Abstract · Added September 24, 2012
Inflammation and angiogenesis are inevitable in vivo responses to biomaterial implants. Continuous progress has been made in biomaterial design to improve tissue interactions with an implant by either reducing inflammation or promoting angiogenesis. However, it has become increasingly clear that the physiological processes of inflammation and angiogenesis are interconnected through various molecular mechanisms. Hence, there is an unmet need for engineering functional tissues by simultaneous activation of pro-angiogenic and anti-inflammatory responses to biomaterial implants. In this work, the modulus and fibrinogen adsorption of porous scaffolds were tuned to meet the requirements (i.e., ~100 kPa and ~10 nm, respectively), for soft tissue regeneration by employing tyrosine-derived combinatorial polymers with polyethylene glycol crosslinkers. Two types of functional peptides (i.e., pro-angiogenic laminin-derived C16 and anti-inflammatory thymosin β4-derived Ac-SDKP) were loaded in porous scaffolds through collagen gel embedding so that peptides were released in a controlled fashion, mimicking degradation of the extracellular matrix. The results from (1) in vitro coculture of human umbilical vein endothelial cells and human blood-derived macrophages and (2) in vivo subcutaneous implantation revealed the directly proportional relationship between angiogenic activities (i.e., tubulogenesis and perfusion capacity) and inflammatory activities (i.e., phagocytosis and F4/80 expression) upon treatment with either type of peptide. Interestingly, cotreatment with both types of peptides upregulated the angiogenic responses, while downregulating the inflammatory responses. Also, anti-inflammatory Ac-SDKP peptides reduced production of pro-inflammatory cytokines (i.e., interleukin [IL]-1β, IL-6, IL-8, and tumor necrosis factor alpha) even when treated in combination with pro-angiogenic C16 peptides. In addition to independent regulation of angiogenesis and inflammation, this study suggests a promising approach to improve soft tissue regeneration (e.g., blood vessel and heart muscle) when inflammatory diseases (e.g., ischemic tissue fibrosis and atherosclerosis) limit the regeneration process.
2 Communities
4 Members
0 Resources
15 MeSH Terms
Comparative effectiveness of antibiotic treatment strategies for pediatric skin and soft-tissue infections.
Williams DJ, Cooper WO, Kaltenbach LA, Dudley JA, Kirschke DL, Jones TF, Arbogast PG, Griffin MR, Creech CB
(2011) Pediatrics 128: e479-87
MeSH Terms: Adolescent, Anti-Infective Agents, Child, Child, Preschool, Clindamycin, Female, Humans, Infant, Male, Methicillin-Resistant Staphylococcus aureus, Retrospective Studies, Skin Diseases, Bacterial, Soft Tissue Infections, Staphylococcal Skin Infections, Trimethoprim, Sulfamethoxazole Drug Combination
Show Abstract · Added February 3, 2014
OBJECTIVE - To compare the effectiveness of clindamycin, trimethoprim-sulfamethoxazole, and β-lactams for the treatment of pediatric skin and soft-tissue infections (SSTIs).
METHODS - A retrospective cohort of children 0 to 17 years of age who were enrolled in Tennessee Medicaid, experienced an incident SSTI between 2004 and 2007, and received treatment with clindamycin (reference), trimethoprim-sulfamethoxazole, or a β-lactam was created. Outcomes included treatment failure and recurrence, defined as an SSTI within 14 days and between 15 and 365 days after the incident SSTI, respectively. Adjusted models stratified according to drainage status were used to estimate the risk of treatment failure and time to recurrence.
RESULTS - Among the 6407 children who underwent drainage, there were 568 treatment failures (8.9%) and 994 recurrences (22.8%). The adjusted odds ratios for treatment failure were 1.92 (95% confidence interval [CI]: 1.49-2.47) for trimethoprim-sulfamethoxazole and 2.23 (95% CI: 1.71-2.90) for β-lactams. The adjusted hazard ratios for recurrence were 1.26 (95% CI: 1.06-1.49) for trimethoprim-sulfamethoxazole and 1.42 (95% CI: 1.19-1.69) for β-lactams. Among the 41 094 children without a drainage procedure, there were 2435 treatment failures (5.9%) and 5436 recurrences (18.2%). The adjusted odds ratios for treatment failure were 1.67 (95% CI: 1.44-1.95) for trimethoprim-sulfamethoxazole and 1.22 (95% CI: 1.06-1.41) for β-lactams; the adjusted hazard ratios for recurrence were 1.30 (95% CI: 1.18-1.44) for trimethoprim-sulfamethoxazole and 1.08 (95% CI: 0.99-1.18) for β-lactams.
CONCLUSIONS - Compared with clindamycin, use of trimethoprim-sulfamethoxazole or β-lactams was associated with increased risks of treatment failure and recurrence. Associations were stronger for those with a drainage procedure.
0 Communities
2 Members
0 Resources
15 MeSH Terms
Variability among pediatric infectious diseases specialists in the treatment and prevention of methicillin-resistant Staphylococcus aureus skin and soft tissue infections.
Creech CB, Beekmann SE, Chen Y, Polgreen PM
(2008) Pediatr Infect Dis J 27: 270-2
MeSH Terms: Community-Acquired Infections, Health Services, Humans, Methicillin Resistance, Soft Tissue Infections, Specialization, Staphylococcal Infections, Staphylococcal Skin Infections, Staphylococcus aureus
Show Abstract · Added February 3, 2014
There are currently no clear consensus recommendations for the treatment and prevention of community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections in pediatric patients. We surveyed over 100 Pediatric Infectious Diseases consultants and found considerable variability in both the treatment of skin and soft tissue infections and the strategies used for the management of children with recurrent MRSA disease.
0 Communities
1 Members
0 Resources
9 MeSH Terms