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Diabetes medication regimens and patient clinical characteristics in the national patient-centered clinical research network, PCORnet.
Bachmann KN, Roumie CL, Wiese AD, Grijalva CG, Buse JB, Bradford R, Zalimeni EO, Knoepp P, Dard S, Morris HL, Donahoo WT, Fanous N, Fonseca V, Katalenich B, Choi S, Louzao D, O'Brien E, Cook MM, Rothman RL, Chakkalakal RJ
(2020) Pharmacol Res Perspect 8: e00637
MeSH Terms: Adult, Aged, Comorbidity, Diabetes Mellitus, Type 2, Dipeptidyl-Peptidase IV Inhibitors, Drug Therapy, Combination, Electronic Health Records, Female, Glucagon-Like Peptide-1 Receptor, Humans, Hyperlipidemias, Hypertension, Hypoglycemic Agents, Insulin, Male, Metformin, Middle Aged, Patient-Centered Care, Retrospective Studies, Sodium-Glucose Transporter 2 Inhibitors, Sulfonylurea Compounds, Thiazolidinediones, United States
Added March 29, 2022
0 Communities
1 Members
0 Resources
MeSH Terms
Genetic ablation of SGLT2 function in mice impairs tissue mineral density but does not affect fracture resistance of bone.
Thrailkill KM, Bunn RC, Uppuganti S, Ray P, Garrett K, Popescu I, Pennings JS, Fowlkes JL, Nyman JS
(2020) Bone 133: 115254
MeSH Terms: Animals, Bone Density, Diabetes Mellitus, Type 2, Female, Femur, Humans, Male, Mice, Mice, Inbred C57BL, Minerals, Sodium-Glucose Transporter 2
Added March 25, 2020
0 Communities
1 Members
0 Resources
11 MeSH Terms
The impact of SGLT2 inhibitors, compared with insulin, on diabetic bone disease in a mouse model of type 1 diabetes.
Thrailkill KM, Nyman JS, Bunn RC, Uppuganti S, Thompson KL, Lumpkin CK, Kalaitzoglou E, Fowlkes JL
(2017) Bone 94: 141-151
MeSH Terms: Animals, Biomarkers, Blood Glucose, Bone Diseases, Metabolic, Bone Resorption, Bone and Bones, Canagliflozin, Diabetes Mellitus, Type 1, Disease Models, Animal, Fibroblast Growth Factor-23, Insulin, Linear Models, Male, Mice, Inbred DBA, Phenotype, Sodium-Glucose Transporter 2, Sodium-Glucose Transporter 2 Inhibitors
Added January 9, 2017
2 Communities
1 Members
0 Resources
17 MeSH Terms
SGLT2 inhibitor therapy improves blood glucose but does not prevent diabetic bone disease in diabetic DBA/2J male mice.
Thrailkill KM, Clay Bunn R, Nyman JS, Rettiganti MR, Cockrell GE, Wahl EC, Uppuganti S, Lumpkin CK, Fowlkes JL
(2016) Bone 82: 101-7
MeSH Terms: Animals, Blood Glucose, Bone Diseases, Canagliflozin, Diabetes Mellitus, Experimental, Male, Mice, Mice, Inbred DBA, Sodium-Glucose Transporter 2, Sodium-Glucose Transporter 2 Inhibitors
Added August 31, 2015
1 Communities
1 Members
0 Resources
10 MeSH Terms
Glucotoxicity targets hepatic glucokinase in Zucker diabetic fatty rats, a model of type 2 diabetes associated with obesity.
Ueta K, O'Brien TP, McCoy GA, Kim K, Healey EC, Farmer TD, Donahue EP, Condren AB, Printz RL, Shiota M
(2014) Am J Physiol Endocrinol Metab 306: E1225-38
MeSH Terms: Animals, Body Weight, Canagliflozin, Diabetes Mellitus, Type 2, Eating, Glucagon, Glucokinase, Glucose, Glucose Clamp Technique, Glucosides, Hyperglycemia, Hyperinsulinism, Immunohistochemistry, Liver, Male, Obesity, Organ Size, Oxygen Consumption, RNA, Messenger, Rats, Rats, Zucker, Sodium-Glucose Transporter 2, Sodium-Glucose Transporter 2 Inhibitors, Thiophenes
Added February 19, 2015
0 Communities
1 Members
0 Resources
24 MeSH Terms
Specific Cre/Lox recombination in the mouse proximal tubule.
Rubera I, Poujeol C, Bertin G, Hasseine L, Counillon L, Poujeol P, Tauc M
(2004) J Am Soc Nephrol 15: 2050-6
MeSH Terms: Animals, Female, Integrases, Kidney Tubules, Proximal, Lac Operon, Mice, Mice, Transgenic, Microvilli, Molecular Biology, Monosaccharide Transport Proteins, Pregnancy, Promoter Regions, Genetic, Reverse Transcriptase Polymerase Chain Reaction, Sodium-Glucose Transporter 2, Transgenes
Added September 9, 2013
0 Communities
0 Members
1 Resources
15 MeSH Terms