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Results: 1 to 10 of 77

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SCN5A variant R222Q generated abnormal changes in cardiac sodium current and action potentials in murine myocytes and Purkinje cells.
Daniel LL, Yang T, Kroncke B, Hall L, Stroud D, Roden DM
(2019) Heart Rhythm 16: 1676-1685
MeSH Terms: Action Potentials, Alleles, Animals, Disease Models, Animal, Echocardiography, Electrocardiography, Mice, Mice, Transgenic, Myocytes, Cardiac, NAV1.5 Voltage-Gated Sodium Channel, Purkinje Cells, Sodium Channels
Added June 14, 2019
1 Communities
2 Members
0 Resources
12 MeSH Terms
Renal Medullary Interstitial COX-2 (Cyclooxygenase-2) Is Essential in Preventing Salt-Sensitive Hypertension and Maintaining Renal Inner Medulla/Papilla Structural Integrity.
Zhang MZ, Wang S, Wang Y, Zhang Y, Ming Hao C, Harris RC
(2018) Hypertension 72: 1172-1179
MeSH Terms: Animals, Apoptosis, Aquaporin 2, Blood Pressure, Cyclooxygenase 2, Epithelial Sodium Channels, Hypertension, Kidney Medulla, Mice, Mice, Transgenic
Added November 8, 2018
1 Communities
0 Members
0 Resources
10 MeSH Terms
Functional features of the "finger" domain of the DEG/ENaC channels MEC-4 and UNC-8.
Matthewman C, Johnson CK, Miller DM, Bianchi L
(2018) Am J Physiol Cell Physiol 315: C155-C163
MeSH Terms: Amino Acid Sequence, Animals, Calcium, Cell Death, Cell Membrane Permeability, Epithelial Sodium Channels, Magnesium, Membrane Proteins, Mutation, Oocytes, Protein Transport, Sodium, Xenopus laevis
Added March 26, 2019
0 Communities
1 Members
0 Resources
13 MeSH Terms
Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension.
Barbaro NR, Foss JD, Kryshtal DO, Tsyba N, Kumaresan S, Xiao L, Mernaugh RL, Itani HA, Loperena R, Chen W, Dikalov S, Titze JM, Knollmann BC, Harrison DG, Kirabo A
(2017) Cell Rep 21: 1009-1020
MeSH Terms: Amiloride, Animals, Cells, Cultured, Cytokines, Dendritic Cells, Epithelial Sodium Channel Blockers, Epithelial Sodium Channels, Hypertension, Inflammation, Male, Mice, Mice, Inbred C57BL, NADPH Oxidases, Oxidative Stress, Prostaglandins E, Protein Kinase C, Sodium, Sodium-Hydrogen Exchanger 1, Superoxides
Added December 27, 2017
0 Communities
2 Members
0 Resources
19 MeSH Terms
Rare variants in genes encoding the cardiac sodium channel and associated compounds and their impact on outcome of catheter ablation of atrial fibrillation.
Husser D, Ueberham L, Hindricks G, B├╝ttner P, Ingram C, Weeke P, Shoemaker MB, Adams V, Arya A, Sommer P, Darbar D, Roden DM, Bollmann A
(2017) PLoS One 12: e0183690
MeSH Terms: Atrial Fibrillation, Catheter Ablation, Humans, Myocardium, Sodium Channels, Treatment Outcome
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Constitutively Active SPAK Causes Hyperkalemia by Activating NCC and Remodeling Distal Tubules.
Grimm PR, Coleman R, Delpire E, Welling PA
(2017) J Am Soc Nephrol 28: 2597-2606
MeSH Terms: Aldosterone, Animals, Blood Pressure, Epithelial Sodium Channels, Hydrochlorothiazide, Kidney Tubules, Distal, Mice, Natriuresis, Phosphorylation, Potassium, Potassium Channels, Inwardly Rectifying, Protein Serine-Threonine Kinases, Pseudohypoaldosteronism, Signal Transduction, Sodium Chloride Symporter Inhibitors, Solute Carrier Family 12, Member 3
Added May 3, 2017
0 Communities
1 Members
0 Resources
16 MeSH Terms
Inflammatory cytokines regulate renal sodium transporters: how, where, and why?
Norlander AE, Madhur MS
(2017) Am J Physiol Renal Physiol 313: F141-F144
MeSH Terms: Animals, Blood Pressure, Cytokines, Epithelial Cells, Epithelial Sodium Channels, Humans, Hypertension, Inflammation Mediators, Kidney, Membrane Transport Proteins, Renal Reabsorption, Signal Transduction, Sodium Chloride, Dietary
Added September 7, 2017
1 Communities
0 Members
0 Resources
13 MeSH Terms
Genetic Determinants of Metabolism and Benign Prostate Enlargement: Associations with Prostate Volume.
Giri A, Edwards TL, Motley SS, Byerly SH, Fowke JH
(2015) PLoS One 10: e0132028
MeSH Terms: Adult, Aged, Collagen Type IV, Genetic Loci, Genotype, Humans, Linear Models, Male, Middle Aged, Nerve Tissue Proteins, Obesity, Organ Size, Polymorphism, Single Nucleotide, Prostate, Prostatic Hyperplasia, Prostatic Neoplasms, Ribosomal Proteins, Sodium Channels, Symporters, Ultrasonography
Added February 22, 2016
0 Communities
2 Members
0 Resources
20 MeSH Terms
Activation of the Endogenous Renin-Angiotensin-Aldosterone System or Aldosterone Administration Increases Urinary Exosomal Sodium Channel Excretion.
Qi Y, Wang X, Rose KL, MacDonald WH, Zhang B, Schey KL, Luther JM
(2016) J Am Soc Nephrol 27: 646-56
MeSH Terms: Adult, Aldosterone, Cross-Over Studies, Epithelial Sodium Channels, Exosomes, Female, Humans, Male, Renin-Angiotensin System, Sodium, Dietary
Added November 30, 2015
0 Communities
3 Members
0 Resources
10 MeSH Terms
Integrated compensatory network is activated in the absence of NCC phosphorylation.
Grimm PR, Lazo-Fernandez Y, Delpire E, Wall SM, Dorsey SG, Weinman EJ, Coleman R, Wade JB, Welling PA
(2015) J Clin Invest 125: 2136-50
MeSH Terms: Amiloride, Ammonia, Animals, Biological Transport, Blood Pressure, Carbonic Anhydrases, Chlorides, Disease Models, Animal, Enzyme Activation, Epithelial Sodium Channels, Gene Expression Profiling, Gene Regulatory Networks, Gitelman Syndrome, Ketoglutaric Acids, Kidney Glomerulus, Male, Mice, Mice, Knockout, Natriuresis, Nephrons, Paracrine Communication, Phosphorylation, Protein Processing, Post-Translational, Protein Serine-Threonine Kinases, Receptors, Notch, Receptors, Purinergic P2, Renal Reabsorption, Signal Transduction, Sodium Chloride, Sodium-Potassium-Chloride Symporters, Solute Carrier Family 12, Member 3
Added May 3, 2017
0 Communities
1 Members
0 Resources
31 MeSH Terms