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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 9 of 9

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Genome-wide association study identifies a new SMAD7 risk variant associated with colorectal cancer risk in East Asians.
Zhang B, Jia WH, Matsuo K, Shin A, Xiang YB, Matsuda K, Jee SH, Kim DH, Cheah PY, Ren Z, Cai Q, Long J, Shi J, Wen W, Yang G, Ji BT, Pan ZZ, Matsuda F, Gao YT, Oh JH, Ahn YO, Kubo M, Thean LF, Park EJ, Li HL, Park JW, Jo J, Jeong JY, Hosono S, Nakamura Y, Shu XO, Zeng YX, Zheng W
(2014) Int J Cancer 135: 948-55
MeSH Terms: Adult, Aged, Alleles, Asians, Case-Control Studies, China, Colorectal Neoplasms, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Japan, Male, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide, Principal Component Analysis, Republic of Korea, Risk, Singapore, Smad7 Protein
Added March 10, 2014
0 Communities
6 Members
0 Resources
22 MeSH Terms
Smad7 inhibits autocrine expression of TGF-β2 in intestinal epithelial cells in baboon necrotizing enterocolitis.
Namachivayam K, Blanco CL, MohanKumar K, Jagadeeswaran R, Vasquez M, McGill-Vargas L, Garzon SA, Jain SK, Gill RK, Freitag NE, Weitkamp JH, Seidner SR, Maheshwari A
(2013) Am J Physiol Gastrointest Liver Physiol 304: G167-80
MeSH Terms: Animals, Autocrine Communication, Blotting, Western, Cell Line, Colon, DNA-Binding Proteins, Disease Models, Animal, Down-Regulation, Enterocolitis, Necrotizing, Gestational Age, Humans, Immunohistochemistry, Intestinal Mucosa, Intracellular Signaling Peptides and Proteins, Papio anubis, Papio cynocephalus, Premature Birth, Proto-Oncogene Proteins, Reverse Transcriptase Polymerase Chain Reaction, Smad7 Protein, Transfection, Transforming Growth Factor beta2
Added February 27, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms
Smad7 induces hepatic metastasis in colorectal cancer.
Halder SK, Rachakonda G, Deane NG, Datta PK
(2008) Br J Cancer 99: 957-65
MeSH Terms: Adenocarcinoma, Animals, Biomarkers, Tumor, Blotting, Western, Cadherins, Cell Proliferation, Claudin-1, Claudin-4, Colorectal Neoplasms, Gene Expression Regulation, Neoplastic, Humans, Liver Neoplasms, Membrane Proteins, Mice, Mice, Nude, Phosphorylation, Polymerase Chain Reaction, Protein Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Signal Transduction, Smad2 Protein, Smad3 Protein, Smad7 Protein, Transforming Growth Factor beta, Tumor Cells, Cultured
Added May 10, 2013
0 Communities
1 Members
0 Resources
26 MeSH Terms
Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus.
Smart NG, Apelqvist AA, Gu X, Harmon EB, Topper JN, MacDonald RJ, Kim SK
(2006) PLoS Biol 4: e39
MeSH Terms: Aging, Animals, Bone Morphogenetic Proteins, Cell Differentiation, Diabetes Mellitus, Embryo, Mammalian, Gene Expression Regulation, Developmental, Growth Differentiation Factors, Homeodomain Proteins, Islets of Langerhans, Maf Transcription Factors, Large, Mice, Mice, Transgenic, Signal Transduction, Smad7 Protein, Trans-Activators, Transforming Growth Factor beta
Added November 6, 2013
0 Communities
1 Members
0 Resources
17 MeSH Terms
Role of Smad proteins in the regulation of NF-kappaB by TGF-beta in colon cancer cells.
Grau AM, Datta PK, Zi J, Halder SK, Beauchamp RD
(2006) Cell Signal 18: 1041-50
MeSH Terms: Active Transport, Cell Nucleus, Activin Receptors, Type I, Animals, Cell Line, Tumor, Cell Nucleus, Colonic Neoplasms, DNA, Enzyme Activation, Epithelial Cells, Humans, I-kappa B Kinase, NF-kappa B, Phosphorylation, Protein Binding, Protein Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type I, Receptors, Transforming Growth Factor beta, Signal Transduction, Smad4 Protein, Smad7 Protein, Transcriptional Activation, Transforming Growth Factor beta, Transforming Growth Factor beta1
Added May 3, 2013
0 Communities
1 Members
0 Resources
23 MeSH Terms
Smad7 induces tumorigenicity by blocking TGF-beta-induced growth inhibition and apoptosis.
Halder SK, Beauchamp RD, Datta PK
(2005) Exp Cell Res 307: 231-46
MeSH Terms: Animals, Apoptosis, Blotting, Western, COS Cells, Cell Line, Chlorocebus aethiops, DNA-Binding Proteins, Dose-Response Relationship, Drug, Gene Expression Regulation, Neoplastic, Growth Inhibitors, Humans, Mice, Mice, Nude, Neoplasm Transplantation, Neoplasms, Precipitin Tests, Retroviridae, Signal Transduction, Smad7 Protein, Trans-Activators, Transcription, Genetic, Transfection, Transforming Growth Factor beta, Transplantation, Heterologous
Added June 14, 2013
1 Communities
1 Members
0 Resources
24 MeSH Terms
Type I transforming growth factor beta receptor binds to and activates phosphatidylinositol 3-kinase.
Yi JY, Shin I, Arteaga CL
(2005) J Biol Chem 280: 10870-6
MeSH Terms: Activin Receptors, Type I, Animals, COS Cells, Cell Line, Culture Media, Serum-Free, DNA-Binding Proteins, Enzyme Activation, Enzyme Inhibitors, Genes, Dominant, Genetic Vectors, Humans, Immunoblotting, Ligands, Mice, Mutation, Phosphatidylinositol 3-Kinases, Phosphorylation, Plasmids, Protein Binding, Protein Serine-Threonine Kinases, Protein Structure, Tertiary, Rabbits, Receptor, Transforming Growth Factor-beta Type I, Receptors, Transforming Growth Factor beta, Reticulocytes, Smad7 Protein, Trans-Activators, Transcriptional Activation, Transfection
Added March 5, 2014
0 Communities
1 Members
0 Resources
29 MeSH Terms
Smad about elastin regulation.
Davidson JM
(2002) Am J Respir Cell Mol Biol 26: 164-6
MeSH Terms: Animals, Connective Tissue Growth Factor, DNA-Binding Proteins, Elastin, Growth Substances, Immediate-Early Proteins, Intercellular Signaling Peptides and Proteins, RNA Stability, RNA, Messenger, Signal Transduction, Smad3 Protein, Smad7 Protein, Trans-Activators, Transforming Growth Factor beta
Added December 10, 2013
0 Communities
1 Members
0 Resources
14 MeSH Terms
STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling.
Datta PK, Moses HL
(2000) Mol Cell Biol 20: 3157-67
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, COS Cells, Cell Line, DNA-Binding Proteins, Humans, Immunoblotting, Phosphorylation, Plasmids, Precipitin Tests, Protein Binding, Proteins, RNA-Binding Proteins, Receptors, Growth Factor, Signal Transduction, Smad2 Protein, Smad3 Protein, Smad6 Protein, Smad7 Protein, Trans-Activators, Transcription, Genetic, Transcriptional Activation, Transforming Growth Factor beta
Added February 17, 2014
0 Communities
1 Members
0 Resources
23 MeSH Terms