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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 27

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Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer.
Means AL, Freeman TJ, Zhu J, Woodbury LG, Marincola-Smith P, Wu C, Meyer AR, Weaver CJ, Padmanabhan C, An H, Zi J, Wessinger BC, Chaturvedi R, Brown TD, Deane NG, Coffey RJ, Wilson KT, Smith JJ, Sawyers CL, Goldenring JR, Novitskiy SV, Washington MK, Shi C, Beauchamp RD
(2018) Cell Mol Gastroenterol Hepatol 6: 257-276
MeSH Terms: Animals, Bone Morphogenetic Protein 2, Carcinoma, Cell Line, Cell Line, Tumor, Colitis, Colorectal Neoplasms, Dextran Sulfate, Humans, Inflammation, Intestinal Mucosa, Mice, Mice, Inbred C57BL, Mice, Transgenic, Smad4 Protein, Transforming Growth Factor beta1
Added September 12, 2018
1 Communities
1 Members
0 Resources
16 MeSH Terms
Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.
Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM
(2016) Nat Med 22: 497-505
MeSH Terms: Animals, Carcinoma, Pancreatic Ductal, Chromatography, Liquid, Collagen, Disease Models, Animal, Disease Progression, Extracellular Matrix, Fibrosis, Genotype, Humans, Integrin beta Chains, Mice, Microscopy, Atomic Force, Mutation, Pancreatic Neoplasms, Prognosis, Proteomics, Proto-Oncogene Proteins p21(ras), Real-Time Polymerase Chain Reaction, STAT3 Transcription Factor, Signal Transduction, Smad4 Protein, Survival Rate, Tandem Mass Spectrometry, Transforming Growth Factor beta, Tumor Microenvironment
Added May 5, 2017
1 Communities
1 Members
0 Resources
26 MeSH Terms
RUNX3 Controls a Metastatic Switch in Pancreatic Ductal Adenocarcinoma.
Whittle MC, Izeradjene K, Rani PG, Feng L, Carlson MA, DelGiorno KE, Wood LD, Goggins M, Hruban RH, Chang AE, Calses P, Thorsen SM, Hingorani SR
(2015) Cell 161: 1345-60
MeSH Terms: Animals, Carcinoma, Pancreatic Ductal, Core Binding Factor Alpha 3 Subunit, Disease Models, Animal, Genes, p53, Humans, Mice, Neoplasm Metastasis, Pancreatic Neoplasms, Proto-Oncogene Proteins p21(ras), Smad4 Protein
Added March 13, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway.
Zhang B, Zhang B, Chen X, Bae S, Singh K, Washington MK, Datta PK
(2014) Br J Cancer 110: 946-57
MeSH Terms: Animals, Antimetabolites, Antineoplastic, Apoptosis Regulatory Proteins, Cell Cycle Proteins, Cell Line, Tumor, Cell Movement, Cell Proliferation, Cell Survival, Chromones, Colorectal Neoplasms, Drug Resistance, Neoplasm, Enzyme Activation, Enzyme Inhibitors, Fluorouracil, Humans, Inhibitor of Apoptosis Proteins, Mice, Mice, Inbred BALB C, Morpholines, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasm Transplantation, Neovascularization, Pathologic, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Phosphorylation, Proteins, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins c-bcl-2, Repressor Proteins, Retinoblastoma Protein, Smad4 Protein, Survivin, Up-Regulation, Vascular Endothelial Growth Factor A, Wound Healing, Xenograft Model Antitumor Assays
Added April 12, 2016
0 Communities
1 Members
0 Resources
37 MeSH Terms
Epithelial stem cell mutations that promote squamous cell carcinoma metastasis.
White RA, Neiman JM, Reddi A, Han G, Birlea S, Mitra D, Dionne L, Fernandez P, Murao K, Bian L, Keysar SB, Goldstein NB, Song N, Bornstein S, Han Z, Lu X, Wisell J, Li F, Song J, Lu SL, Jimeno A, Roop DR, Wang XJ
(2013) J Clin Invest 123: 4390-404
MeSH Terms: Animals, Carcinogenesis, Carcinoma, Squamous Cell, Cell Dedifferentiation, Cell Proliferation, Epithelial-Mesenchymal Transition, Female, Gene Expression Regulation, Neoplastic, Humans, Mice, Mice, Nude, Mice, Transgenic, MicroRNAs, Mutation, Missense, Neoplasm Transplantation, Neoplastic Stem Cells, Proto-Oncogene Proteins, Proto-Oncogene Proteins p21(ras), RNA Interference, Sequence Deletion, Side-Population Cells, Skin Neoplasms, Smad4 Protein, Tumor Cells, Cultured, alpha Catenin, ras Proteins
Added September 27, 2013
1 Communities
0 Members
0 Resources
26 MeSH Terms
TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer.
Bhola NE, Balko JM, Dugger TC, Kuba MG, Sánchez V, Sanders M, Stanford J, Cook RS, Arteaga CL
(2013) J Clin Invest 123: 1348-58
MeSH Terms: Animals, Antineoplastic Agents, Phytogenic, Breast Neoplasms, Cell Line, Tumor, Drug Resistance, Neoplasm, Female, Gene Expression, Gene Knockdown Techniques, Humans, Interleukin-8, Mice, Mice, Nude, Neoplastic Stem Cells, Paclitaxel, Protein-Serine-Threonine Kinases, Pyrazoles, Quinolines, RNA, Small Interfering, Receptor, ErbB-2, Receptor, Transforming Growth Factor-beta Type I, Receptors, Estrogen, Receptors, Progesterone, Receptors, Transforming Growth Factor beta, Signal Transduction, Smad4 Protein, Spheroids, Cellular, Transforming Growth Factor beta, Xenograft Model Antitumor Assays
Added September 3, 2013
1 Communities
5 Members
0 Resources
28 MeSH Terms
Molecular imaging of gastric neoplasia with near-infrared fluorescent activatable probes.
Ding S, Eric Blue R, Chen Y, Scull B, Kay Lund P, Morgan D
(2012) Mol Imaging 11: 507-15
MeSH Terms: Animals, Cathepsins, Fluorescent Dyes, Matrix Metalloproteinases, Mice, Mice, Inbred C57BL, Molecular Imaging, Smad4 Protein, Stomach Neoplasms
Added May 20, 2016
0 Communities
1 Members
0 Resources
9 MeSH Terms
Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of β-catenin.
Freeman TJ, Smith JJ, Chen X, Washington MK, Roland JT, Means AL, Eschrich SA, Yeatman TJ, Deane NG, Beauchamp RD
(2012) Gastroenterology 142: 562-571.e2
MeSH Terms: Adenocarcinoma, Adenomatous Polyposis Coli, Aged, Animals, Binding Sites, Bone Morphogenetic Proteins, Colorectal Neoplasms, Down-Regulation, Female, Genes, APC, HCT116 Cells, HEK293 Cells, Humans, Laser Capture Microdissection, Male, Mice, Mice, Knockout, Mice, Transgenic, Middle Aged, Oligonucleotide Array Sequence Analysis, RNA Polymerase II, RNA, Messenger, Smad4 Protein, Wnt Signaling Pathway, beta Catenin
Added July 19, 2013
2 Communities
6 Members
0 Resources
25 MeSH Terms
BMP-2 and TGFβ2 shared pathways regulate endocardial cell transformation.
Townsend TA, Robinson JY, Deig CR, Hill CR, Misfeldt A, Blobe GC, Barnett JV
(2011) Cells Tissues Organs 194: 1-12
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Bone Morphogenetic Protein 2, Chick Embryo, Endocardium, Humans, Signal Transduction, Smad4 Protein, Transfection, Transforming Growth Factor beta2, Transforming Growth Factor beta3
Added February 21, 2016
0 Communities
1 Members
0 Resources
11 MeSH Terms
Antimetastatic role of Smad4 signaling in colorectal cancer.
Zhang B, Halder SK, Kashikar ND, Cho YJ, Datta A, Gorden DL, Datta PK
(2010) Gastroenterology 138: 969-80.e1-3
MeSH Terms: Adenocarcinoma, Animals, Antineoplastic Agents, Cadherins, Cell Line, Tumor, Cell Movement, Cell Proliferation, Colorectal Neoplasms, Female, Humans, Liver Neoplasms, Matrix Metalloproteinase 9, Mice, Mice, Inbred C57BL, Mice, Nude, NM23 Nucleoside Diphosphate Kinases, Neoplasm Invasiveness, Protein Kinase Inhibitors, Pyrazoles, Pyrroles, Receptors, Transforming Growth Factor beta, Signal Transduction, Smad4 Protein, Time Factors, Transfection, Transforming Growth Factor beta1, Urokinase-Type Plasminogen Activator
Added March 5, 2014
1 Communities
1 Members
0 Resources
27 MeSH Terms