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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 40

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Genetic Engineering of Mesenchymal Stem Cells for Differential Matrix Deposition on 3D Woven Scaffolds.
Huynh NPT, Brunger JM, Gloss CC, Moutos FT, Gersbach CA, Guilak F
(2018) Tissue Eng Part A 24: 1531-1544
MeSH Terms: Adult, Cells, Cultured, Chondrogenesis, Collagen Type II, Core Binding Factor Alpha 1 Subunit, Extracellular Matrix, Gene Knockdown Techniques, Genetic Engineering, Glycosaminoglycans, Humans, Mesenchymal Stem Cells, Minerals, Osteogenesis, Smad3 Protein, Tissue Engineering, Tissue Scaffolds, Transforming Growth Factor beta3
Added March 16, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Loss of tumour suppressor PTEN expression in renal injury initiates SMAD3- and p53-dependent fibrotic responses.
Samarakoon R, Helo S, Dobberfuhl AD, Khakoo NS, Falke L, Overstreet JM, Goldschmeding R, Higgins PJ
(2015) J Pathol 236: 421-32
MeSH Terms: Animals, Apoptosis, Aristolochic Acids, Cell Cycle Checkpoints, Cell Line, Cell Proliferation, Disease Models, Animal, Enzyme Inhibitors, Fibrosis, Gene Expression Regulation, Humans, Kidney Diseases, Kidney Tubules, Male, Mice, Inbred C57BL, PTEN Phosphohydrolase, Plasminogen Activator Inhibitor 1, RNA Interference, Signal Transduction, Smad3 Protein, Streptozocin, Transfection, Transforming Growth Factor beta1, Tumor Suppressor Protein p53, Ureteral Obstruction
Added April 19, 2016
0 Communities
1 Members
0 Resources
25 MeSH Terms
Tumor suppressor ataxia telangiectasia mutated functions downstream of TGF-β1 in orchestrating profibrotic responses.
Overstreet JM, Samarakoon R, Cardona-Grau D, Goldschmeding R, Higgins PJ
(2015) FASEB J 29: 1258-68
MeSH Terms: Animals, Ataxia Telangiectasia Mutated Proteins, Cell Line, Epithelial Cells, Fibrosis, Gene Expression Regulation, Gene Knockdown Techniques, Humans, Kidney, Mice, Models, Biological, NADPH Oxidases, Phosphorylation, Rats, Signal Transduction, Smad3 Protein, Transforming Growth Factor beta1, Tumor Suppressor Protein p53
Added April 19, 2016
0 Communities
1 Members
0 Resources
18 MeSH Terms
Anti-remodeling and anti-fibrotic effects of the neuregulin-1β glial growth factor 2 in a large animal model of heart failure.
Galindo CL, Kasasbeh E, Murphy A, Ryzhov S, Lenihan S, Ahmad FA, Williams P, Nunnally A, Adcock J, Song Y, Harrell FE, Tran TL, Parry TJ, Iaci J, Ganguly A, Feoktistov I, Stephenson MK, Caggiano AO, Sawyer DB, Cleator JH
(2014) J Am Heart Assoc 3: e000773
MeSH Terms: Actins, Animals, Cells, Cultured, Disease Models, Animal, Dose-Response Relationship, Drug, Fibrosis, Gene Expression Regulation, Heart Failure, Male, Mice, Inbred C57BL, Myocardial Contraction, Myocardium, Myofibroblasts, Neuregulin-1, Phosphorylation, Rats, Sprague-Dawley, Smad3 Protein, Swine, Time Factors, Transcription, Genetic, Ventricular Function, Left, Ventricular Remodeling
Added March 15, 2017
0 Communities
1 Members
0 Resources
22 MeSH Terms
Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling.
Chen X, Wang H, Liao HJ, Hu W, Gewin L, Mernaugh G, Zhang S, Zhang ZY, Vega-Montoto L, Vanacore RM, Fässler R, Zent R, Pozzi A
(2014) J Clin Invest 124: 3295-310
MeSH Terms: Animals, Collagen, Epithelial-Mesenchymal Transition, Fibrosis, Integrin alpha1, Integrin alpha1beta1, Kidney, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Phosphorylation, Protein Tyrosine Phosphatase, Non-Receptor Type 2, Protein-Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Signal Transduction, Smad Proteins, Smad2 Protein, Smad3 Protein, Tyrosine, Ureteral Obstruction
Added October 27, 2014
2 Communities
4 Members
1 Resources
23 MeSH Terms
Redox control of p53 in the transcriptional regulation of TGF-β1 target genes through SMAD cooperativity.
Overstreet JM, Samarakoon R, Meldrum KK, Higgins PJ
(2014) Cell Signal 26: 1427-36
MeSH Terms: Acetylation, Animals, Cell Line, DNA-Binding Proteins, Enzyme Activation, Epithelial Cells, Fibroblasts, Fibrosis, Gene Expression Regulation, Humans, Keratinocytes, Kidney Diseases, Kidney Tubules, Mice, Mice, Knockout, NADPH Oxidases, Phosphorylation, Plasminogen Activator Inhibitor 1, Promoter Regions, Genetic, RNA Interference, RNA, Small Interfering, Reactive Oxygen Species, Signal Transduction, Smad3 Protein, Transcriptional Activation, Transforming Growth Factor beta1, Tumor Suppressor Protein p53
Added April 19, 2016
0 Communities
1 Members
0 Resources
27 MeSH Terms
Transforming growth factor β regulates P-body formation through induction of the mRNA decay factor tristetraprolin.
Blanco FF, Sanduja S, Deane NG, Blackshear PJ, Dixon DA
(2014) Mol Cell Biol 34: 180-95
MeSH Terms: 3' Untranslated Regions, AU Rich Elements, Animals, Binding Sites, Cell Line, Cell Proliferation, Cellular Senescence, Colon, Cytoplasmic Structures, Intestinal Mucosa, Mice, Mice, Knockout, Promoter Regions, Genetic, RNA Processing, Post-Transcriptional, RNA Stability, RNA, Messenger, Rats, Signal Transduction, Smad3 Protein, Transcriptional Activation, Transforming Growth Factor beta, Tristetraprolin
Added March 7, 2014
1 Communities
1 Members
0 Resources
22 MeSH Terms
Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species.
Samarakoon R, Dobberfuhl AD, Cooley C, Overstreet JM, Patel S, Goldschmeding R, Meldrum KK, Higgins PJ
(2013) Cell Signal 25: 2198-209
MeSH Terms: Animals, Benzothiazoles, Connective Tissue Growth Factor, Endothelium, Vascular, ErbB Receptors, Fibroblasts, Fibrosis, Gene Expression Regulation, Isoquinolines, Mice, Mink, Myocytes, Smooth Muscle, Pyridines, Pyrroles, Quinazolines, Rats, Reactive Oxygen Species, Renal Insufficiency, Chronic, Serpin E2, Signal Transduction, Smad2 Protein, Smad3 Protein, Toluene, Transforming Growth Factor beta1, Tumor Suppressor Protein p53, Tyrphostins
Added April 19, 2016
0 Communities
1 Members
0 Resources
26 MeSH Terms
Transforming growth factor β induces expression of connective tissue growth factor in hepatic progenitor cells through Smad independent signaling.
Ding ZY, Jin GN, Liang HF, Wang W, Chen WX, Datta PK, Zhang MZ, Zhang B, Chen XP
(2013) Cell Signal 25: 1981-92
MeSH Terms: Connective Tissue Growth Factor, DNA-Binding Proteins, Gene Expression Regulation, Hepatocytes, Humans, Liver, Liver Cirrhosis, MAP Kinase Signaling System, Signal Transduction, Smad2 Protein, Smad3 Protein, Stem Cells, Transforming Growth Factor beta
Added February 26, 2014
1 Communities
1 Members
0 Resources
13 MeSH Terms
TGF-β signaling in tissue fibrosis: redox controls, target genes and therapeutic opportunities.
Samarakoon R, Overstreet JM, Higgins PJ
(2013) Cell Signal 25: 264-8
MeSH Terms: ErbB Receptors, Fibrosis, Humans, NADPH Oxidases, Oxidation-Reduction, Plasminogen Activator Inhibitor 1, Reactive Oxygen Species, Signal Transduction, Smad2 Protein, Smad3 Protein, Transforming Growth Factor beta, Tumor Suppressor Protein p53
Added April 19, 2016
0 Communities
1 Members
0 Resources
12 MeSH Terms